Breath actuated dry powder inhaler and tape dose strip

• US 7,322,354 B2
• Filed: 11/10/2004
• Issued: 01/29/2008
• Est. Priority Date: 02/01/2000
• Status: Expired due to Term

• Current Assignee: Aptar France S.A.S (AptarGroup Incorporated)
• Original Assignee: Valois SAS (Mestdagh Family)
• Inventors: Kay, Stuart, Young, Matthew, Harrison, Neil, Darby, Ian, Rogerson, Cheryl Vanessa, Crew, Peter, Powell, Anne
• Primary Examiner(s): Yu; Justine R.
• Assistant Examiner(s): Ali; Shumaya B.
• Application Number:
  US10/984,870
• Publication Number:
  US 20050081853A1
• Time in Patent Office: 1,175 Days
• Field of Search: 128/203.15, 128/203.21, 128/604, 128/58, 128/203.12, 128/103.19, 128/203.19, 128/200.14, 128/200.21, 128/200.23, 128/200.12, 604/58, 222/94, 222/103, 222/160, 222/541.1
• US Class Current: 128/203.15
• CPC Class Codes: A61M 15/0008 rotating by airflow
• CPC Class Codes: A61M 15/0031 by bursting or breaking the package, i.e. without cutting or piercing
• CPC Class Codes: A61M 15/0043 Non-destructive separation of the package, e.g. peeling
• CPC Class Codes: A61M 15/0045 using multiple prepacked dosages on a same carrier, e.g. blisters
• CPC Class Codes: A61M 15/0048 the dosages being arranged in a plane, e.g. on diskettes
• CPC Class Codes: A61M 15/0051 the dosages being arranged on a tape, e.g. strips
• CPC Class Codes: A61M 15/006 the used dosages being discarded out of the inhaler's housing
• CPC Class Codes: A61M 15/0086 Inhalation chambers
• CPC Class Codes: A61M 15/0091 mechanically breath-triggered
• CPC Class Codes: A61M 15/0096 Hindering inhalation before activation of the dispenser
• CPC Class Codes: A61M 15/02 with activated or ionised fluids, e.g. electrohydrodynamic [EHD] or electrostatic devices; Ozone-inhalators with radioactive tagged particles
• CPC Class Codes: A61M 2202/064 Powder
• CPC Class Codes: A61M 2206/16 Rotating swirling helical flow, e.g. by tangential inflows
• CPC Class Codes: B65D 75/327 and forming several compartments

Abstract

A method for operating a dry powder inhaler, the dry powder inhaler having a dose tape having spaced apart doses of a powder pharmaceutical, each dose being in a respective sealed blister. The inhaler includes a breath actuated blister opening system that sequentially opens a blister on the tape. The method involves routing the dose tape between first and second rotating elements; spring biasing the first rotating element to turn in a first direction; holding the first rotating element from rotating against the spring biasing; and releasing the first rotating element, and allowing it to rotate a fraction of one rotation, when air flows adjacent to the first rotating element.

Claims

1. A method for operating a dry powder inhaler, providing a dry powder inhaler, said dry powder inhaler comprising a dose tape having spaced apart doses of a powder pharmaceutical, each dose being in a respective sealed blister, said inhaler comprising a blister opening system which sequentially opens a blister on the tape, said blister opening system being breath actuated, the method comprising the steps of:

routing the dose tape between first and second rotating elements;

spring biasing the first rotating element to turn in a first direction;

holding the first rotating element from rotating, against the spring biasing; and

releasing the first rotating element, and allowing it to rotate a fraction of one rotation, when air flows adjacent to the first rotating element.

2. The method of claim 1 wherein the first rotating element comprises a ratchet.

3. The method of claim 2 wherein the first rotating element comprises a drive spool engaged by the ratchet.

4. The method of claim 1 wherein the second rotating element comprises a capstan.

5. The method of claim 1 further comprising the step of tensioning the spring by moving a dustcap on the inhaler.

6. The method of claim 1 further comprising the step of separating an area of a second layer of a dose tape from a first layer of the dose tape with rotating movement of the first rotating element.

7. A method for operating a dry powder inhaler, providing a dry powder inhaler, said dry powder inhaler comprising a dose tape having spaced apart doses of a powder pharmaceutical, each dose being in a respective sealed blister, said inhaler comprising a blister opening system which sequentially opens a blister on the tape, said blister opening system being breath actuated, the method comprising the steps of:

routing the dose tape between first and second rotating elements;

spring biasing the first rotating element to turn in a first direction;

holding the first rotating element from rotating against the spring biasing; and

triggering the release of the first rotating element by inhaling through the inhaler.

8. The method of claim 7, wherein the step of triggering the release of the first rotating element by inhaling through the inhaler causes air to flow adjacent to the first rotating element.

9. The method of claim 7, wherein the step of triggering the release of the first rotating element by inhaling through the inhaler causes the first rotating element to rotate only a fraction of one rotation.

10. The method of claim 7, wherein the first rotating element comprises a drive spool engaged by a ratchet.

11. The method of claim 10, wherein the second rotating element comprises a capstan.

12. The method of claim 7, further comprising the step of tensioning the spring by moving a dustcap on the inhaler.

13. The method of claim 7, further comprising the step of separating an area of a second layer of a dose tape from a first layer of the dose tape by rotating the first rotating element.

14. A method for operating a dry powder inhaler, comprising the steps of:

providing the dry powder inhaler, which comprises a dose tape having spaced apart doses of a powder pharmaceutical, each dose being in a separately sealed blister, the inhaler comprising a blister opening mechanism for sequentially opening each sealed blister on the tape, wherein the blister opening mechanism is breath actuated;

routing the dose tape between first and second rotating elements;

spring biasing the first rotating element to turn in a first direction;

holding the first rotating element from rotating against the spring biasing; and

actuating the blister opening mechanism and triggering the release of the first rotating element by inhaling through the inhaler.