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Identification of molecular sequence signatures and methods involving the same

  • US 7,323,307 B2
  • Filed: 08/04/2004
  • Issued: 01/29/2008
  • Est. Priority Date: 09/19/1996
  • Status: Expired due to Fees
First Claim
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1. A method for analyzing a mRNA, said mRNA comprising one or more exons having an order, said order defined by one or more sequence signatures, each said one or more sequence signatures comprising a sequence spanning two exons, said method comprising;

  • providing said mRNA;

    processing said mRNA to provide labeled nucleic acid fragments corresponding to said exons and said sequence signatures;

    hybridizing said labeled fragments to a nucleic acid array, wherein said nucleic acid array comprises probes corresponding to said one or more exons and to said one or more sequence signatures; and

    determining the identity of said sequence signatures and order of each said one or more exons to analyze the mRNA.

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