Methods and compositions for healing and repair of articular cartilage

• US 7,323,445 B2
• Filed: 02/18/2004
• Issued: 01/29/2008
• Est. Priority Date: 02/01/1999
• Status: Expired due to Term

• Current Assignee: Genetics Institute LLC (Pfizer Inc.)
• Original Assignee: Genetics Institute LLC (Pfizer Inc.)
• Inventors: Zhang, Renwen, Peluso, Diane, Morris, Elisabeth
• Primary Examiner(s): ROBINSON, HOPE A
• Application Number:
  US10/779,638
• Publication Number:
  US 20040192605A1
• Time in Patent Office: 1,441 Days
• Field of Search: None
• US Class Current: 514/8.8
• CPC Class Codes: A61K 38/00 Medicinal preparations containing peptides peptides containing beta-lactam rings A61K31/00; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, A61K31/00; ergot alkaloids of the cyclic peptide type A61K31/48; containing macromolecular compounds having statistically distributed amino acid units A61K31/74; medicinal preparations containing antigens or antibodies A61K39/00; medicinal preparations characterised by the non-active ingredients, e.g. peptides as drug carriers, A61K47/00
• CPC Class Codes: A61K 38/1875 Bone morphogenic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
• CPC Class Codes: A61L 2430/06 for cartilage reconstruction, e.g. meniscus
• CPC Class Codes: A61L 27/227 Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
• CPC Class Codes: A61L 27/3608 Bone, e.g. demineralised bone matrix [DBM], bone powder
• CPC Class Codes: A61L 27/3612 Cartilage, synovial fluid
• CPC Class Codes: A61L 27/3654 Cartilage, e.g. meniscus
• CPC Class Codes: A61P 19/00 Drugs for skeletal disorders
• CPC Class Codes: A61P 19/02 for joint disorders, e.g. arthritis, arthrosis
• CPC Class Codes: A61P 19/04 for non-specific disorders of the connective tissue
• CPC Class Codes: C07K 14/51 Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor

Abstract

Methods and compositions are provided for the treatment of articular cartilage defects and disease involving the combination of tissue, such as osteochondral grafts, with active growth factor. The active growth factor is preferably a composition containing at least one bone morphogenetic protein and a suitable carrier. The method results in the regeneration and/or functional repair of articular cartilage tissue.

Claims

1. A method for regeneration of articular cartilage comprising administering to an area in need of regeneration of said articular cartilage an osteochondral graft having applied thereto a composition consisting essentially of an amount of a heterodimer effective for the regeneration of articular cartilage, wherein the heterodimer comprises one purified bone morphogenetic protein (BMP) selected from the group consisting of BMP-2, 4, 5, 6, and 7 and one protein which induces the formation of tendon or ligament tissue selected from the group consisting of BMP-12, BMP-13, and MP52.

2. The method of claim 1, wherein said BMP is BMP-2.

3. A method for regeneration of articular cartilage comprising administering to an area in need of regeneration of said articular cartilage an osteochondral graft having applied thereto a composition consisting essentially of

(i) an amount of at least one purified bone morphogenetic protein (BMP) selected from the group consisting of BMP-2, 4, 5, 6, and 7 effective for the regeneration of said articular cartilage and

(ii) one or more pharmaceutical carriers.

4. The method of claim 3, wherein said pharmaceutical carrier is hyaluronic acid.

5. The method of claim 3, wherein the pharmaceutical carrier is a mineral.

6. The method of claim 5, wherein said mineral is calcium phosphate.

7. The method of claim 3, wherein said pharmaceutical carrier is a ceramic.

8. The method of claim 7, wherein said ceramic is hydroxyapatite.

18. The method of claim 3, wherein the BMP is BMP-2.

9. A method for regeneration of articular cartilage comprising administering to an area in need of regeneration of said articular cartilage an osteochondral graft and a composition consisting essentially of an amount of at least one purified bone mor ho enetic protein (BMP) selected from the group consisting of BMP-2, 4, 5, 6, and 7 effective for the regeneration of said articular cartilage, wherein said composition is applied directly to the osteochondral graft and/or administered directly to the site in need of tissue repair in conjunction with the graft.

10. The method of claim 9, wherein said composition is applied to the graft or the site in need of tissue repair using a syringe for injection.

11. A method for regeneration of articular cartilage comprising administering to an area in need of regeneration of said articular cartilage an osteochondral graft having applied thereto a composition consisting essentially of an amount of at least one purified bone morphogenetic protein (BMP) selected from the group consisting of BMP-2, 4, 5, 6, and 7 effective for the regeneration of said articular cartilage, wherein the area in need of regeneration of said articular cartilage is selected from the group consisting of the hip and the knee.

12. The method of claim 11, wherein the area in need of regeneration of said articular cartilage is the hip.

13. The method of claim 11, wherein the area in need of regeneration of said articular cartilage is the knee.

14. The method of claim 13, wherein the area in need of regeneration of articular cartilage is the trochlear groove.

15. The method of claim 13, wherein the area in need of regeneration of articular cartilage is the femoral condyle.

16. The method of claim 15, wherein the area in need of regeneration of articular cartilage is the medial femoral condyle.

17. The method of claim 15, wherein the area in need of regeneration of articular cartilage is the lateral femoral condyle.