Nucleotide derivative and DNA microarray
First Claim
1. A nucleotide derivative having a fluorescent dye intercalator bound via a linker to a pyrimidine base or a purine base, which, when existing as a member of a single-stranded sequence is selected from the group consisting of:
- (1) a thymine/uracil derivative represented by Formula (1);
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Abstract
A novel nucleotide derivative, in case of existing as a member of a single-stranded sequence, undergoing a change in the fluorescent signal intensity depending on the corresponding base type in the partner strand with which the single-stranded sequence is hybridized, and which is (1) a thymine/uracil derivative emitting light most intensely when a confronting base in the partner strand with which the single-stranded nucleotide sequence is hybridized is adenine; (2) a cytosine derivative emitting light most intensely when the confronting base is guanine; (3) an adenine derivative emitting light most intensely when the confronting base is cytosine; and, (4) a guanine derivative emitting light most intensely when the confronting base is cytosine or thymine/uracil.
4 Citations
13 Claims
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1. A nucleotide derivative having a fluorescent dye intercalator bound via a linker to a pyrimidine base or a purine base, which, when existing as a member of a single-stranded sequence is selected from the group consisting of:
(1) a thymine/uracil derivative represented by Formula (1); - View Dependent Claims (6, 7, 8, 9, 10, 11, 12, 13)
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2. A nucleoside derivative that is a precursor of a thymine/uracil derivative and is represented by Formula (5):
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3. A nucleoside derivative that is a precursor of a cytosine derivative and is represented by Formula (6):
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4. A nucleoside derivative that is a precursor of an adenine derivative and is represented by Formula (7):
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5. A nucleoside derivative that is a precursor of a guanine derivative and is represented by Formula (8):
Specification