Cardiac disease treatment and device

• US 7,326,174 B2
• Filed: 05/04/2004
• Issued: 02/05/2008
• Est. Priority Date: 06/12/2000
• Status: Expired due to Fees

• Current Assignee: Mardil, Inc.
• Original Assignee: Acorn Cardiovascular, Inc.
• Inventors: Cox, James, Shapland, J. Edward II, Rohrbaugh, Donald G., Sabbah, Hani N., Girard, Michael J., Walsh, Robert G., Palme, Donald F. II
• Primary Examiner(s): Hindenburg; Max F.
• Assistant Examiner(s): SZMAL, BRIAN SCOTT
• Application Number:
  US10/839,724
• Publication Number:
  US 20050004428A1
• Time in Patent Office: 1,372 Days
• Field of Search: 600/37, 600/16, 604/20, 607/9
• US Class Current: 600/37
• CPC Class Codes: A61F 2/2481 Devices outside the heart wall, e.g. bags, strips or bands
• CPC Class Codes: A61P 9/00 Drugs for disorders of the cardiovascular system
• CPC Class Codes: A61P 9/04 Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
• CPC Class Codes: A61P 9/06 Antiarrhythmics
• CPC Class Codes: D04B 21/12 characterised by thread material
• CPC Class Codes: D10B 2509/08 Hernia repair mesh
• CPC Class Codes: Y10S 977/907 Liposome

Abstract

A device for treating cardiac disease of a heart having an upper portion and a lower portion divided by an A-V groove, the device including a jacket adapted to be secured to the heart, and a non-adherent material in association with the jacket. The jacket is fabricated from a flexible material defining a volume between an upper and a lower end, the jacket being adapted to be adjusted on the heart to snugly conform to an external geometry of the heart and assume a maximum adjusted volume for the jacket to constrain expansion of the heart beyond the maximum adjusted volume during diastole and permit substantially unimpeded contraction of the heart during systole. As a result of the flexible material, the jacket allows unimpeded diastolic filling of the heart. Also described is a method for treating cardiac disease including surgically accessing the heart, applying the treatment device of the invention, securing the treatment device to the heart, and surgically closing access to the heart while leaving the treatment device on the heart.

Claims

1. A device for treating cardiac disease of a heart having an upper portion and a lower portion divided by an A-V groove, the device comprising:

a. a jacket of flexible material defining a volume between an upper end and a lower end, the jacket adapted to be secured to the heart and adapted to be adjusted on the heart to snugly conform to an external geometry of the heart and assume a volume for the jacket to constrain expansion of the heart during diastole and permit substantially unimpeded contraction of the heart during systole;

b. a non-adherent material coating on the flexible material of the jacket; and

c. a delivery source including one or more therapeutic agents on the non-adherent material coating for the delivery of the one or more therapeutic agents to the surface of the heart.

2. The device according to claim 1 wherein the delivery source is positioned at a location on the jacket to provide localized delivery of the one or more therapeutic agents to a target area portion on the surface of the heart.

3. The device according to claim 1 wherein the therapeutic agent comprises a pharmacological agent.

4. The device according to claim 1 wherein the therapeutic agent comprises cellular material.

5. The device according to claim 1 wherein the delivery source comprises a coating on the non-adherent material coating of the jacket.

6. The device according to claim 1 wherein the delivery source comprises a separable element from the jacket.

7. The device according to claim 1 wherein the non-adherent material is permeable to the therapeutic agent(s).