High throughput screening of crystallization of materials
First Claim
1. A system for crystallizing a target material comprising:
- an elastomeric block including a microfabricated chamber configured to contain a volume of a solution of the target material; and
a microfabricated flow channel in fluid communication with the chamber, the flow channel introducing a volume of a crystallizing agent into the chamber.
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Accused Products
Abstract
High throughput screening of crystallization of a target material is accomplished by simultaneously introducing a solution of the target material into a plurality of chambers of a microfabricated fluidic device. The microfabricated fluidic device is then manipulated to vary the solution condition in the chambers, thereby simultaneously providing a large number of crystallization environments. Control over changed solution conditions may result from a variety of techniques, including but not limited to metering volumes of crystallizing agent into the chamber by volume exclusion, by entrapment of volumes of crystallizing agent determined by the dimensions of the microfabricated structure, or by cross-channel injection of sample and crystallizing agent into an array of junctions defined by intersecting orthogonal flow channels.
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Citations
13 Claims
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1. A system for crystallizing a target material comprising:
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an elastomeric block including a microfabricated chamber configured to contain a volume of a solution of the target material; and a microfabricated flow channel in fluid communication with the chamber, the flow channel introducing a volume of a crystallizing agent into the chamber. - View Dependent Claims (2, 3, 4, 5, 6, 7)
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8. A system for crystallizing a target material comprising:
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an elastomeric block including a microfabricated chamber configured to contain a volume of a solution of the target material; and a crystallizing agent reservoir in fluid communication with the microfabricated chamber through a dialysis membrane, the dialysis membrane configured to prevent flow of the target material into the crystallizing agent reservoir. - View Dependent Claims (9, 10, 11, 12, 13)
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Specification