Substituted tricyclic compound as protein kinase inhibitors
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Abstract
Protein kinase inhibitors are disclosed having utility in the treatment of protein kinase-mediated diseases and conditions, such as cancer. The compounds of this invention have the following structure:
including steroisomers, prodrugs and pharmaceutically acceptable salts thereof, wherein A is a ring moiety selected from:
and wherein R1, R2, R3, X, Z, L1, Cycl1, L2 and Cycl2 are as defined herein. Also disclosed are compositions containing a compound of this invention, as well as methods relating to the use thereof.
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Citations
10 Claims
- 1. A compound having the following structure:
- 5. A compound having the following structure:
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8. A compound having the following structure:
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9. A compound having the following structure:
Specification