Programmable molecular manipulating processes

• US 7,326,923 B2
• Filed: 04/04/2007
• Issued: 02/05/2008
• Est. Priority Date: 10/14/2004
• Status: Expired due to Fees

• Current Assignee: International Business Machines Corporation
• Original Assignee: International Business Machines Corporation
• Inventors: Berstis, Viktors
• Primary Examiner(s): Kim; Robert
• Assistant Examiner(s): Smith, II; Johnnie L
• Application Number:
  US11/696,364
• Publication Number:
  US 20070190562A1
• Time in Patent Office: 307 Days
• Field of Search: 250/309, 250/281, 435/6, 435/91.2, 369/126
• US Class Current: 250/281
• CPC Class Codes: B82B 3/00 Manufacture or treatment of nanostructures by manipulation of individual atoms or molecules, or limited collections of atoms or molecules as discrete units
• CPC Class Codes: G01Q 70/06 Probe tip arrays
• CPC Class Codes: G01Q 80/00 Applications, other than SPM, of scanning-probe techniques manufacture or treatment of nanostructures B82B3/00; recording or reproducing information using near-field interaction G11B9/12, G11B11/24, G11B13/08

Abstract

A system manipulates molecules using a set of proximal probes such as those used in atomic force microscopes. An electrostatic pattern is placed on a set of proximal probes such that each proximal probe may exert an electrostatic force. A molecule is captured using those electrostatic forces, after which the molecule can be manipulated while the molecule remains captured by the proximal probes. The electrostatic pattern can be modified such that the molecule moves and/or rotates over the set of proximal probes while the molecule remains captured by the set of proximal probes. The electrostatic pattern can be used to bend or split the molecule while the molecule remains captured by the set of proximal probes, thereby allowing the system to engage the molecule in chemical reactions, e.g., to act as a synthetic catalyst or a synthetic enzyme.

Claims

1. A computer program product on a computer readable medium for use in a data processing system for manipulating a molecule, the computer program product comprising:

means for placing an electrostatic pattern on a subset of two or more proximal probes in a set of proximal probes;

means for capturing a molecule using electrostatic forces that are exerted by the electrostatic pattern; and

means for manipulating the molecule while the molecule remains captured by the set of proximal probes.

2. The computer program product of claim 1 further comprising:

means for applying an electric potential to a conductive material in each proximal probe in the subset of proximal probes such that an end portion of each proximal probe in the subset of proximal probes exerts an electrostatic force.

3. The computer program product of claim 1 further comprising:

means for independently controlling each proximal probe in the subset of proximal probes such that each proximal probe in the subset of proximal probes is able to exert an electrostatic force strength that is unique among the subset of proximal probes.

4. The computer program product of claim 1 further comprising:

means for modifying the electrostatic pattern to create a different electrostatic pattern on a different subset of two or more proximal probes in the set of proximal probes such that the molecule moves and/or rotates over the set of proximal probes while the molecule remains captured by the set of proximal probes.

5. The computer program product of claim 1 further comprising:

means for modifying the electrostatic pattern to bend the molecule while the molecule remains captured by the set of proximal probes.

6. The computer program product of claim 1 further comprising:

means for modifying the electrostatic pattern to split the molecule into a first molecule and a second molecule.

7. The computer program product of claim 6 further comprising:

means for continuing to hold the first molecule or the second molecule by the set of proximal probes; and

means for manipulating the first molecule or the second molecule with the set of proximal probes.

8. The computer program product of claim 1 further comprising:

means for modifying the electrostatic pattern to create a first electrostatic pattern on a first subset of two or more proximal probes in the set of proximal probes and a second electrostatic pattern on a second subset of two or more proximal probes in the set of proximal probes.

9. The computer program product of claim 8 further comprising:

means for manipulating the first electrostatic pattern and the second electrostatic pattern independently.

10. The computer program product of claim 8 further comprising:

means for acting independently on a first portion of the molecule with the first electrostatic pattern and on a second portion of the molecule with the second electrostatic pattern.

11. The computer program product of claim 1 wherein the subset of two or more proximal probes in a set of proximal probes represents a first subset of proximal probes, wherein the electrostatic pattern represents a first electrostatic pattern, and wherein the molecule represents a first molecule, further comprising:

means for placing an electrostatic pattern on a second subset of two or more proximal probes in the set of proximal probes, wherein the first subset and the second subset do not intersect;

means for capturing a second molecule using electrostatic forces that are exerted by the second electrostatic pattern; and

means for manipulating the second molecule while the second molecule remains captured by the set of proximal probes.

12. The computer program product of claim 11 further comprising:

means for manipulating the first molecule and the second molecule independently while the first molecule and the second molecule remain captured by the set of proximal probes.

13. The computer program product of claim 11 further comprising:

means for moving the first molecule into close proximity with the second molecule while the first molecule and the second molecule remain captured by the set of proximal probes; and

means for causing a chemical reaction between the first molecule and the second molecule.

14. The computer program product of claim 13 further comprising:

means for forming a third molecule from at least a portion of the first molecule and at least a portion of the second molecule while the third molecule.

15. The computer program product of claim 11 wherein two or more proximal probes in the set of proximal probes include a cantilevered structure.

16. The computer program product of claim 15 wherein each proximal probe in the subset of proximal probes includes a cantilevered structure, further comprising:

means for flexing independently at least two of the proximal probes in the subset of proximal probes to bend the molecule while the molecule remains captured by the set of proximal probes.

17. The computer program product of claim 15 wherein each proximal probe in the subset of proximal probes includes a cantilevered structure, further comprising:

means for flexing independently at least two of the proximal probes in the subset of proximal probes to split the molecule into a first molecule and a second molecule.

18. The computer program product of claim 17 further comprising:

means for continuing to hold the first molecule or the second molecule by the set of proximal probes; and

means for manipulating the first molecule or the second molecule with the set of proximal probes.

19. The computer program product of claim 11 further comprising:

means for using the molecule in a chemical reaction while the molecule remains captured by the set of proximal probes.

20. The computer program product of claim 11 further comprising:

means for using the molecule as a catalyst in a chemical reaction while the molecule remains captured by the set of proximal probes.

21. The computer program product of claim 11 further comprising:

means for using the molecule as an enzyme in a biological reaction while the molecule remains captured by the set of proximal probes.

22. The computer program product of claim 11 wherein a first set of proximal probes are physically connected as a first entity and a second set of proximal probes are physically connected as a second entity such that the first entity and the second entity can be independently manipulated.

23. The computer program product of claim 22 further comprising:

means for holding the captured molecule by the first entity and the second entity simultaneously.

24. The computer program product of claim 23 further comprising:

means for manipulating the first entity while the second entity remains stationary.

25. The computer program product of claim 24 further comprising:

means for bending the molecule while the molecule remains captured by the set of proximal probes.

26. The computer program product of claim 24 further comprising:

means for splitting the molecule into a first molecule and a second molecule.

27. The computer program product of claim 11 further comprising:

means for repeatedly manipulating at least a portion of the molecule while at least a portion of the molecule remains captured by the set of proximal probes.

28. The computer program product of claim 27 further comprising:

means for creating a new molecule that includes the portion of the molecule through a sequence of manipulations that includes the portion of the molecule.

29. The computer program product of claim 28 further comprising:

means for assembling the new molecule by adding portions of other molecules to the portion of the molecule.

30. The computer program product of claim 28 further comprising:

means for disassembling the molecule by removing portions of the molecule.

31. The computer program product of claim 11 wherein the means for manipulating the molecule comprises means for folding the molecule.

32. The computer program product of claim 11 wherein the molecule is a protein.

33. The computer program product of claim 11 wherein the molecule is a piece of a deoxyribonucleic acid (DNA) molecule.