Cancer detection and adaptive dose optimization treatment system
First Claim
Patent Images
1. A method for imaging and treating a sample, the method comprising the steps of:
- a) illuminating the sample with electromagnetic radiation from an illumination source;
b) obtaining a plurality of images from the sample, said plurality of images obtained from illuminating the sample with electromagnetic radiation from the illumination source;
c) producing a plurality of signals, each signal from said plurality of signals corresponding to one of said plurality of images;
d) calculating, from at least one signal from said plurality of signals, a location and spatial shape for treatment on the sample;
e) spatially shaping in substantially real time, using the calculated spatial shape, a treatment electromagnetic radiation beam in order to configure the electromagnetic radiation beam to substantially cover the treatment location;
f) varying an intensity profile of the treatment electromagnetic radiation beam; and
,g) illuminating the treatment location with the spatially shaped treatment electromagnetic radiation beam, subsequent to illuminating the sample with electromagnetic radiation from the illumination source, in order to treat the sample;
said substantially real time spatially shaping the treatment electromagnetic radiation beam precluding scanning the treatment electromagnetic radiation beam.
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Abstract
The present invention utilizes a series of optical and electronic elements to detect and image cancerous and/or pre-cancerous cells in living tissue. The invention further uses the images thus obtained to adaptively and dynamically shape a treatment light beam so as to maximize the beam'"'"'s intensity in proportion to the areas with the most cancer or pre-cancer and to minimize the irradiation of normal tissue by the beam.
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Citations
42 Claims
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1. A method for imaging and treating a sample, the method comprising the steps of:
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a) illuminating the sample with electromagnetic radiation from an illumination source; b) obtaining a plurality of images from the sample, said plurality of images obtained from illuminating the sample with electromagnetic radiation from the illumination source; c) producing a plurality of signals, each signal from said plurality of signals corresponding to one of said plurality of images; d) calculating, from at least one signal from said plurality of signals, a location and spatial shape for treatment on the sample; e) spatially shaping in substantially real time, using the calculated spatial shape, a treatment electromagnetic radiation beam in order to configure the electromagnetic radiation beam to substantially cover the treatment location; f) varying an intensity profile of the treatment electromagnetic radiation beam; and
,g) illuminating the treatment location with the spatially shaped treatment electromagnetic radiation beam, subsequent to illuminating the sample with electromagnetic radiation from the illumination source, in order to treat the sample; said substantially real time spatially shaping the treatment electromagnetic radiation beam precluding scanning the treatment electromagnetic radiation beam. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
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12. A system for imaging and treating samples, the system comprising:
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an illumination source of electromagnetic radiation, said illumination source capable of illuminating a sample with electromagnetic radiation; an optical sub-system capable of collecting a plurality of images of the sample, said plurality of images resulting from illuminating the sample with electromagnetic radiation from the illumination source, and capable of focusing electromagnetic radiation onto the sample; an image detector capable of capturing at least one image from said plurality of images of the sample and producing at least one detector signal; a processing/control sub-system capable of calculating location and spatial shape data for at least one location for treatment on the sample, said calculation based on said at least one detector signal; and
,a treatment electromagnetic radiation source capable of producing a treatment electromagnetic radiation beam formed to substantially cover said treatment location; said treatment electromagnetic radiation beam being emitted subsequent to illuminating the sample with electromagnetic radiation from the illumination source;
said treatment electromagnetic radiation source comprising;a treatment beam source; a treatment beam shaping mechanism capable of shaping, in substantially real time, a treatment beam emanating from said treatment beam source; and said processing/control sub-system also being capable of providing shaping data, said shaping data obtained from calculating location and spatial shape data, and control information to said treatment beam shaping mechanism;
said substantially real time spatially shaping the treatment electromagnetic radiation beam precluding scanning the treatment electromagnetic radiation beam;said optical subsystem being also capable of directing said treatment electromagnetic radiation beam at said at least one treatment location. - View Dependent Claims (13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27)
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28. A system for imaging and treating samples, the system comprising:
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an illumination source of electromagnetic radiation said illumination source capable of illuminating a sample with electromagnetic radiation; an optical sub-system capable of collecting a plurality of images of the sample, said plurality of images resulting from illuminating the sample with electromagnetic radiation from the illumination source, and capable of focusing electromagnetic radiation onto the sample; an image detector capable of capturing at least one image from said plurality of images of the sample and producing at least one detector signal; a processing/control sub-system capable of calculating location and spatial shape data for at least one location for treatment on the sample, said calculation based on said at least one detector signal; and a treatment electromagnetic radiation source capable of producing a treatment electromagnetic radiation beam formed to substantially cover said treatment location; said treatment electromagnetic radiation beam being emitted subsequent to illuminating the sample with electromagnetic radiation from the illumination source;
said treatment electromagnetic radiation source comprising;a treatment beam source; a treatment beam shaping mechanism capable of shaping a treatment beam emanating from said treatment beam source; and said processing/control sub-system also being capable of providing shaping data, said shaping data obtained from calculation location and spatial shape data, and control information to said treatment beam shaping mechanism; said optical subsystem being also capable of directing said treatment electromagnetic radiation beam at said at least one treatment location; and wherein said optical sub-system comprises; at least one filter; and wherein said at least one filter comprises at least two filters and said processing/control sub-system is also capable of providing control signals for selecting at least one filter from said at least two filters. - View Dependent Claims (29)
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30. A system for imaging and treating samples, the system comprising:
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an illumination source of electromagnetic radiation, said illumination source capable of illumination a sample with electromagnetic radiation; an optical sub-system capable of collecting a plurality of images of the sample, said plurality of images resulting from illuminating the sample with electromagnetic radiation from the illumination source and capable of focusing electromagnetic radiation onto the sample; an image detector capable of capturing at least one image from said plurality of images of the sample and producing at least one detector signal; a processing/control sub-system capable of calculating location and spatial shape data for at least one location for treatment on the sample said calculation based on said at least one detector signal; and a treatment electromagnetic radiation source capable of producing a treatment electromagnetic radiation beam formed to substantially cover said treatment location; said treatment electromagnetic radiation beam being emitted subsequent to illuminating the sample with electromagnetic radiation from the illumination source;
said treatment electromagnetic radiation source comprising;a treatment beam source; a treatment beam shaping mechanism capable of shaping a treatment beam emanating from said treatment beam source; and said processing/control sub-system also being capable of providing shaping data, said shaping data obtained from calculating location and spatial shape data, and control information to said treatment beam shaping mechanism; said optical subsystem being also capable of directing said treatment electromagnetic radiation beam at said at least one treatment location; and wherein said optical sub-system comprises; at least one filter; and wherein said optical sub-system further comprises an imaging lens component.
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31. A system for imaging and treating sample, the system comprising:
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an illumination source of electromagnetic radiation said illumination source capable of illuminating a sample with electromagnetic radiation; an optical sub-system capable of collecting a plurality of images of the sample, said plurality of images resulting from illuminating the sample with electromagnetic radiation from the illumination source and capable of focusing electromagnetic radiation onto the sample; an image detector capable of capturing at least one image from said plurality of images of the sample and producing at least one detector signal; a processing/control sub-system capable of calculating location and spatial shape data for at least one location for treatment on the sample said calculation based on said at least one detector signal; and a treatment electromagnetic radiation source capable of producing a treatment electromagnetic radiation beam formed to substantially cover said treatment location; said treatment electromagnetic radiation beam being emitted subsequent to illuminating the sample with electromagnetic radiation from the illumination source;
said teamed electromagnetic radiation source comprising;a treatment beam source; a treatment beam shaping mechanism capable of shaping a treatment beam emanating from said treatment beam source; and said processing/control sub-system also begin capable of providing shaping data, said shaping data obtained from calculation location and spatial shape data, and control information to said treatment beam shaping mechanism; said optical subsystem being also capable of directing said treatment electromagnetic radiation beam at said at least one treatment location; wherein said optical sub-system comprises; a plurality of imaging lens elements; and
,a plurality of filters.
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32. A system for imaging and treating sample, the system comprising;
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an illumination source of electromagnetic radiation said illumination source capable of illuminating a sample with electromagnetic radiation; an optical sub-system capable of collecting a plurality of images of the sample, said plurality of images resulting from illuminating the sample with electromagnetic radiation from the illumination source and capable of focusing electromagnetic radiation onto the sample; an image detector capable of capturing at least one image from said plurality of images of the sample and producing at least one detector signal; a processing/control sub-system capable of calculating location and spatial shape data for at least one location for treatment on the sample said calculation based on said at least one detector signal; and a treatment electromagnetic radiation source capable of producing a treatment electromagnetic radiation beam formed to substantially cover said treatment location; said treatment electromagnetic radiation beam being emitted subsequent to illuminating the sample with electromagnetic radiation from the illumination source;
said treatment electromagnetic radiation source comprising;a treatment beam source; a treatment beam shaping mechanism capable of shaping a treatment beam emanating from said treatment beam source; and said processing/control sub-system also being capable of providing shaping data, said shaping data obtained from calculating location and spatial shape data, and control information to said treatment beam shaping mechanism; said optical subsystem being also capable of directing said treatment electromagnetic radiation beam at said at least one treatment location; and wherein said optical sub-system comprises; a plurality of optical filters, a plurality of imaging lenses, and a multi-faceted refracting prism. - View Dependent Claims (33, 34, 35, 36, 37, 38, 39, 40, 41)
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42. A system for imaging and treating samples, the system comprising:
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an illumination source of electromagnetic radiation, said illumination source capable of illuminating a sample with electromagnetic radiation; an optical sub-system capable of collecting a plurality of images of the sample, said plurality of images resulting from illuminating the sample with electromagnetic radiation from the illumination source, and capable of focusing electromagnetic radiation onto the sample; an image detector capable of capturing at least one image from said plurality of images of the sample and producing at least one detector signal; a processing/control sub-system capable of calculating location and spatial shape data for at least one location for treatment on the sample, said calculation based on said at least one detector signal; and
,a treatment electromagnetic radiation source capable of producing a treatment electromagnetic radiation beam formed to substantially cover said treatment location; said treatment electromagnetic radiation beam being emitted subsequent to illuminating the sample with electromagnetic radiation from the illumination source;
said treatment electromagnetic radiation source comprising;a treatment beam source; a treatment beam shaping mechanism capable of shaping a treatment beam emanating from said treatment beam source; and said processing/control sub-system also being capable of providing shaping data, said shaping data obtained from calculating location and spatial shape data, and control information to said treatment beam shaping mechanism; said optical subsystem being also capable of directing said treatment electromagnetic radiation beam at said at least treatment location; and wherein said optical sub-system comprises; a first optical sub-system; a second optical sub-system; an aperture stop optically disposed between said first optical sub-system and said second optical sub-system; said first optical sub-system being capable of directing incoming electromagnetic radiation to a location of said aperture stop; a beam separating sub-system capable of receiving electromagnetic radiation from said first optical sub-system and separating received electromagnetic radiation into a plurality of beams of electromagnetic radiation, a location of said beam separating sub-system being substantially coincident with the location of said aperture stop; and said second optical sub-system being capable of imaging said plurality of beams of electromagnetic radiation received from said beam separating sub-system into a plurality of images on image plane.
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Specification