Cancer detection and adaptive dose optimization treatment system

• US 7,328,060 B2
• Filed: 02/12/2003
• Issued: 02/05/2008
• Est. Priority Date: 02/12/2002
• Status: Expired due to Fees

• Current Assignee: Foster-Miller Incorporated (Thermo Fisher Scientific Incorporated)
• Original Assignee: Science & Engineering Associates, Inc. (Perspecta, Inc.)
• Inventors: Saggese, Steven, Tocci, Nora C., Tocci, Michael D., Mooradian, Gregory C.
• Primary Examiner(s): Mercader; Eleni Mantis
• Assistant Examiner(s): Cheng; Jacqueline
• Application Number:
  US10/365,012
• Publication Number:
  US 20030153825A1
• Time in Patent Office: 1,819 Days
• Field of Search: 600/407, 600/410, 600/476, 600/473
• US Class Current: 600/476
• CPC Class Codes: A61B 18/20 using laser
• CPC Class Codes: A61B 2017/00057 Light
• CPC Class Codes: A61B 2018/00636 Sensing and controlling the application of energy
• CPC Class Codes: A61B 5/0059 using light, e.g. diagnosis by transillumination, diascopy, fluorescence A61B5/0093, A61B5/1455, A61B5/02416 and A61B5/0261 take precedence
• CPC Class Codes: A61N 5/062 Photodynamic therapy, i.e. excitation of an agent

Abstract

The present invention utilizes a series of optical and electronic elements to detect and image cancerous and/or pre-cancerous cells in living tissue. The invention further uses the images thus obtained to adaptively and dynamically shape a treatment light beam so as to maximize the beam'"'"'s intensity in proportion to the areas with the most cancer or pre-cancer and to minimize the irradiation of normal tissue by the beam.

Claims

1. A method for imaging and treating a sample, the method comprising the steps of:

a) illuminating the sample with electromagnetic radiation from an illumination source;

b) obtaining a plurality of images from the sample, said plurality of images obtained from illuminating the sample with electromagnetic radiation from the illumination source;

c) producing a plurality of signals, each signal from said plurality of signals corresponding to one of said plurality of images;

d) calculating, from at least one signal from said plurality of signals, a location and spatial shape for treatment on the sample;

e) spatially shaping in substantially real time, using the calculated spatial shape, a treatment electromagnetic radiation beam in order to configure the electromagnetic radiation beam to substantially cover the treatment location;

f) varying an intensity profile of the treatment electromagnetic radiation beam; and

,

g) illuminating the treatment location with the spatially shaped treatment electromagnetic radiation beam, subsequent to illuminating the sample with electromagnetic radiation from the illumination source, in order to treat the sample;

said substantially real time spatially shaping the treatment electromagnetic radiation beam precluding scanning the treatment electromagnetic radiation beam.

2. The method of claim 1 further comprising the step of:

repeating steps b) through g) automatically until a predetermined condition occurs.

3. The method of claim 1 further comprising the step of:

repeating steps (a) through (g) upon user input.

4. The method of claim 1 further comprising the step of:

displaying an image of the sample.

5. The method of claim 1 wherein the step of repeating steps b) through g) further comprises the step of:

repeating steps b) through g) automatically until user input indicates a termination of treatment.

6. The method of claim 1 wherein said treatment electromagnetic radiation beam comprises said illumination beam of electromagnetic radiation.

7. The method of claim 1 wherein the sample is a living tissue sample.

8. The method of claim 1 wherein the step of obtaining a plurality of images from the sample comprises the step of:

simultaneously obtaining a plurality of images from the sample.

9. The method of claim 1 wherein the step of illuminating the sample with electromagnetic radiation comprises the step of:

illuminating the sample with an illumination beam of electromagnetic radiation;

and, wherein the step of illuminating the treatment location with the shaped treatment electromagnetic radiation beam comprises the step of;

illuminating the treatment location with the shaped treatment electromagnetic radiation beam simultaneously with said illuminating the sample with said illumination beam of electromagnetic radiation.

10. The method of claim 9 wherein the step of illuminating the sample with an illumination beam further comprises the step of:

illuminating the sample with an illumination beam colinear with an optic axis of an optical system;

and wherein the step of illuminating the treatment location with the shaped treatment electromagnetic radiation beam further comprises the step of;

illuminating the treatment location with the shaped treatment electromagnetic radiation beam colinear with said optic axis.

11. The method of claim 1 wherein the step of calculating, from at least one signal from said plurality of signals, said at least one signal comprises at least two signals and the step of calculating comprises the step of:

comparing at least two signals from said plurality of signals.

12. A system for imaging and treating samples, the system comprising:

an illumination source of electromagnetic radiation, said illumination source capable of illuminating a sample with electromagnetic radiation;

an optical sub-system capable of collecting a plurality of images of the sample, said plurality of images resulting from illuminating the sample with electromagnetic radiation from the illumination source, and capable of focusing electromagnetic radiation onto the sample;

an image detector capable of capturing at least one image from said plurality of images of the sample and producing at least one detector signal;

a processing/control sub-system capable of calculating location and spatial shape data for at least one location for treatment on the sample, said calculation based on said at least one detector signal; and

,

a treatment electromagnetic radiation source capable of producing a treatment electromagnetic radiation beam formed to substantially cover said treatment location;

said treatment electromagnetic radiation beam being emitted subsequent to illuminating the sample with electromagnetic radiation from the illumination source;

said treatment electromagnetic radiation source comprising;

a treatment beam source;

a treatment beam shaping mechanism capable of shaping, in substantially real time, a treatment beam emanating from said treatment beam source; and

said processing/control sub-system also being capable of providing shaping data, said shaping data obtained from calculating location and spatial shape data, and control information to said treatment beam shaping mechanism;

said substantially real time spatially shaping the treatment electromagnetic radiation beam precluding scanning the treatment electromagnetic radiation beam;

said optical subsystem being also capable of directing said treatment electromagnetic radiation beam at said at least one treatment location.

13. The system of claim 12 further comprising:

a user input device operably connected to said processing/control sub-system, said user input device being capable of providing information to the processing/control sub-system.

14. The system of claim 12 wherein said optical sub-system includes a controllable transmission component.

15. The system of claim 14 wherein said controllable transmission component comprises a moveable reflective element.

16. The system of claim 15 wherein said processing/control sub-system is also capable of providing control signals for positioning said moveable reflective element.

17. The system of claim 14 wherein said controllable transmission component comprises a filter.

18. The system of claim 14 wherein said controllable transmission component is selected from the group consisting of polarizing beam-splitter, partial mirror and dichroic reflector.

19. The system of claim 12 wherein said processing/control sub-system is also capable of modifying the radiation from said illumination source.

20. The system of claim 12 wherein said optical sub system comprises:

at least one filter.

21. The system of claim 12 wherein said treatment beam shaping mechanism comprises a liquid crystal array.

22. The system of claim 12 wherein said treatment beam shaping mechanism comprises a micro-mirror array.

23. The system of claim 12 wherein said treatment beam shaping mechanism comprises an acousto-optic modulator.

24. The system of claim 12 wherein said treatment beam shaping mechanism comprises a digital light processor.

25. The system of claim 12 wherein said treatment beam source comprises said illumination source.

26. The system of claim 12 wherein said processing/control sub-system is also capable of modifying said treatment beam source.

27. The system of claim 26 wherein said modification comprises varying an intensity profile of said treatment beam source.

28. A system for imaging and treating samples, the system comprising:

an illumination source of electromagnetic radiation said illumination source capable of illuminating a sample with electromagnetic radiation;

an optical sub-system capable of collecting a plurality of images of the sample, said plurality of images resulting from illuminating the sample with electromagnetic radiation from the illumination source, and capable of focusing electromagnetic radiation onto the sample;

an image detector capable of capturing at least one image from said plurality of images of the sample and producing at least one detector signal;

a processing/control sub-system capable of calculating location and spatial shape data for at least one location for treatment on the sample, said calculation based on said at least one detector signal; and

a treatment electromagnetic radiation source capable of producing a treatment electromagnetic radiation beam formed to substantially cover said treatment location;

said treatment electromagnetic radiation beam being emitted subsequent to illuminating the sample with electromagnetic radiation from the illumination source;

said treatment electromagnetic radiation source comprising;

a treatment beam source;

a treatment beam shaping mechanism capable of shaping a treatment beam emanating from said treatment beam source; and

said processing/control sub-system also being capable of providing shaping data, said shaping data obtained from calculation location and spatial shape data, and control information to said treatment beam shaping mechanism;

said optical subsystem being also capable of directing said treatment electromagnetic radiation beam at said at least one treatment location; and

wherein said optical sub-system comprises;

at least one filter; and

wherein said at least one filter comprises at least two filters and said processing/control sub-system is also capable of providing control signals for selecting at least one filter from said at least two filters.

29. The system of claim 28 wherein said optical sub-system is capable of substantially sequentially collecting a plurality of filtered images of sample.

30. A system for imaging and treating samples, the system comprising:

an illumination source of electromagnetic radiation, said illumination source capable of illumination a sample with electromagnetic radiation;

an optical sub-system capable of collecting a plurality of images of the sample, said plurality of images resulting from illuminating the sample with electromagnetic radiation from the illumination source and capable of focusing electromagnetic radiation onto the sample;

an image detector capable of capturing at least one image from said plurality of images of the sample and producing at least one detector signal;

a processing/control sub-system capable of calculating location and spatial shape data for at least one location for treatment on the sample said calculation based on said at least one detector signal; and

a treatment electromagnetic radiation source capable of producing a treatment electromagnetic radiation beam formed to substantially cover said treatment location;

said treatment electromagnetic radiation beam being emitted subsequent to illuminating the sample with electromagnetic radiation from the illumination source;

said treatment electromagnetic radiation source comprising;

a treatment beam source;

a treatment beam shaping mechanism capable of shaping a treatment beam emanating from said treatment beam source; and

said processing/control sub-system also being capable of providing shaping data, said shaping data obtained from calculating location and spatial shape data, and control information to said treatment beam shaping mechanism;

said optical subsystem being also capable of directing said treatment electromagnetic radiation beam at said at least one treatment location; and

wherein said optical sub-system comprises;

at least one filter; and

wherein said optical sub-system further comprises an imaging lens component.

31. A system for imaging and treating sample, the system comprising:

an illumination source of electromagnetic radiation said illumination source capable of illuminating a sample with electromagnetic radiation;

an optical sub-system capable of collecting a plurality of images of the sample, said plurality of images resulting from illuminating the sample with electromagnetic radiation from the illumination source and capable of focusing electromagnetic radiation onto the sample;

an image detector capable of capturing at least one image from said plurality of images of the sample and producing at least one detector signal;

a processing/control sub-system capable of calculating location and spatial shape data for at least one location for treatment on the sample said calculation based on said at least one detector signal; and

a treatment electromagnetic radiation source capable of producing a treatment electromagnetic radiation beam formed to substantially cover said treatment location;

said treatment electromagnetic radiation beam being emitted subsequent to illuminating the sample with electromagnetic radiation from the illumination source;

said teamed electromagnetic radiation source comprising;

a treatment beam source;

a treatment beam shaping mechanism capable of shaping a treatment beam emanating from said treatment beam source; and

said processing/control sub-system also begin capable of providing shaping data, said shaping data obtained from calculation location and spatial shape data, and control information to said treatment beam shaping mechanism;

said optical subsystem being also capable of directing said treatment electromagnetic radiation beam at said at least one treatment location;

wherein said optical sub-system comprises;

a plurality of imaging lens elements; and

,

a plurality of filters.

32. A system for imaging and treating sample, the system comprising;

an illumination source of electromagnetic radiation said illumination source capable of illuminating a sample with electromagnetic radiation;

an optical sub-system capable of collecting a plurality of images of the sample, said plurality of images resulting from illuminating the sample with electromagnetic radiation from the illumination source and capable of focusing electromagnetic radiation onto the sample;

an image detector capable of capturing at least one image from said plurality of images of the sample and producing at least one detector signal;

a processing/control sub-system capable of calculating location and spatial shape data for at least one location for treatment on the sample said calculation based on said at least one detector signal; and

a treatment electromagnetic radiation source capable of producing a treatment electromagnetic radiation beam formed to substantially cover said treatment location;

said treatment electromagnetic radiation beam being emitted subsequent to illuminating the sample with electromagnetic radiation from the illumination source;

said treatment electromagnetic radiation source comprising;

a treatment beam source;

a treatment beam shaping mechanism capable of shaping a treatment beam emanating from said treatment beam source; and

said processing/control sub-system also being capable of providing shaping data, said shaping data obtained from calculating location and spatial shape data, and control information to said treatment beam shaping mechanism;

said optical subsystem being also capable of directing said treatment electromagnetic radiation beam at said at least one treatment location; and

wherein said optical sub-system comprises;

a plurality of optical filters,

a plurality of imaging lenses, and

a multi-faceted refracting prism.

33. The system of claim 32 wherein said optical sub-system further comprises a dichroic mirror.

34. The system of claim 33 wherein said dichroic mirror is optically disposed between the sample and a remainder of said optical sub-system.

35. The system of claim 33 wherein said dichroic minor is optically disposed between said image detector and a remainder of components of said optical sub-system.

36. The system of claim 32 wherein said optical sub-system further comprises a polarizing beam splitter.

37. The system of claim 36 wherein said polarizing beam splitter is optically disposed between the sample and a remainder of components of said optical sub-system.

38. The system of claim 36 wherein said polarizing beam splitter is optically disposed between said image detector and a remainder of components of said optical sub-system.

39. The system of claim 32 wherein said optical sub-system further comprises an optical reflective element.

40. The system of claim 32 wherein said optical sub-system is capable of substantially simultaneously collecting a plurality of filtered images of the sample.

41. The system of claim 32 wherein said optical sub-system is capable of collecting a plurality of filtered images of the sample and substantially simultaneously focusing electromagnetic radiation onto the sample.

42. A system for imaging and treating samples, the system comprising:

an illumination source of electromagnetic radiation, said illumination source capable of illuminating a sample with electromagnetic radiation;

an optical sub-system capable of collecting a plurality of images of the sample, said plurality of images resulting from illuminating the sample with electromagnetic radiation from the illumination source, and capable of focusing electromagnetic radiation onto the sample;

an image detector capable of capturing at least one image from said plurality of images of the sample and producing at least one detector signal;

a processing/control sub-system capable of calculating location and spatial shape data for at least one location for treatment on the sample, said calculation based on said at least one detector signal; and

,

a treatment electromagnetic radiation source capable of producing a treatment electromagnetic radiation beam formed to substantially cover said treatment location;

said treatment electromagnetic radiation beam being emitted subsequent to illuminating the sample with electromagnetic radiation from the illumination source;

said treatment electromagnetic radiation source comprising;

a treatment beam source;

a treatment beam shaping mechanism capable of shaping a treatment beam emanating from said treatment beam source; and

said processing/control sub-system also being capable of providing shaping data, said shaping data obtained from calculating location and spatial shape data, and control information to said treatment beam shaping mechanism;

said optical subsystem being also capable of directing said treatment electromagnetic radiation beam at said at least treatment location; and

wherein said optical sub-system comprises;

a first optical sub-system;

a second optical sub-system;

an aperture stop optically disposed between said first optical sub-system and said second optical sub-system;

said first optical sub-system being capable of directing incoming electromagnetic radiation to a location of said aperture stop;

a beam separating sub-system capable of receiving electromagnetic radiation from said first optical sub-system and separating received electromagnetic radiation into a plurality of beams of electromagnetic radiation, a location of said beam separating sub-system being substantially coincident with the location of said aperture stop; and

said second optical sub-system being capable of imaging said plurality of beams of electromagnetic radiation received from said beam separating sub-system into a plurality of images on image plane.