Methods of imaging and treatment
First Claim
1. A therapeutic ultrasound method comprising:
- (i) administering to a patient a vesicle composition which comprises vesicles comprising a lipid encapsulating a gas;
optionally in combination with a targeting ligand; and
(ii) exposing said patient to a first ultrasound energy having a first insonation frequency, wherein the exposure to the first insonication frequeney causes the vesicles to oscillate; and
(iii) subsequently exposing the patient to a second ultrasound energy having a second insonation frequency,wherein the first insonation frequency is different from the second insonation frequency, and wherein the exposure to the second insonication frequency is conducted while the vesicles are oscillating.
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Abstract
Novel ultrasound methods comprising administering to a patient a targeted vesicle composition which comprises vesicles comprising a lipid, protein or polymer, encapsulating a gas, in combination with a targeting ligand, and scanning the patient using ultrasound. The scanning may comprise exposing the patient to a first type of ultrasound energy and then interrogating the patient using a second type of ultrasound energy. The targeting ligand preferably targets tissues, cells or receptors, including myocardial cells, endothelial cells, epithelial cells, tumor cells and the glycoprotein GPIIbIIIa receptor. The methods may be used to detect a thrombus, enhancement of an old or echogenic thrombus, low concentrations of vesicles and vesicles targeted to tissues, cells or receptors.
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Citations
59 Claims
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1. A therapeutic ultrasound method comprising:
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(i) administering to a patient a vesicle composition which comprises vesicles comprising a lipid encapsulating a gas;
optionally in combination with a targeting ligand; and(ii) exposing said patient to a first ultrasound energy having a first insonation frequency, wherein the exposure to the first insonication frequeney causes the vesicles to oscillate; and (iii) subsequently exposing the patient to a second ultrasound energy having a second insonation frequency, wherein the first insonation frequency is different from the second insonation frequency, and wherein the exposure to the second insonication frequency is conducted while the vesicles are oscillating. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59)
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Specification