Biodegradable polymer for marking tissue and sealing tracts
First Claim
1. A combination tissue marker polymer and sealant, wherein said tissue marker polymer is formed of a biodegradable polymer and wherein said sealant encapsulates the tissue marker polymer and anchors the tissue marker against migration.
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Abstract
A tissue marker formed of a biodegradable polymer having drug-delivery capabilities is combined with a sealant that encapsulates the tissue marker and which serves to help anchor the tissue marker against migration. The sealant is delivered to a site in dehydrated form and moisture inherent in tissue at the site expands the sealant. The expanded sealant is formed of a hydrogel and is therefore more compatible to the surrounding tissue than the material of the tissue marker. The sealant and the tissue marker are both bioabsorbed over time.
101 Citations
29 Claims
- 1. A combination tissue marker polymer and sealant, wherein said tissue marker polymer is formed of a biodegradable polymer and wherein said sealant encapsulates the tissue marker polymer and anchors the tissue marker against migration.
- 15. A method for anchoring an implant at a specific site, comprising the steps of encapsulating a polymer selected from a group of polymers consisting of poly(dioxanone), polyethylene glycol, polylactides, polyglycolides, polycaprolactone, and their copolymers encapsulated within a cross-linked polyethylene glycol-based hydrogel.
- 28. A method for fabricating tubular implants for implanting in tubular organs, comprising the step of forming a lumen defined by a polymer selected from a group of polymers consisting of poly(dioxanone), polyethylene glycol polylactides, polyglycolides, polycaprolactone, and their copolymers and a cross-linked polyethylene glycol-based hydrogel that provides the exterior of the implant so that as the cross-linked network of hydrophilic polyethylene glycol-based hydrogels expands upon contact with a liquid fluid, it anchors itself into the surrounding tissue.
Specification