Medicament dispensing device with a display indicative of the state of an internal medicament reservoir

• US 7,331,340 B2
• Filed: 03/04/2004
• Issued: 02/19/2008
• Est. Priority Date: 03/04/2003
• Status: Expired due to Term

• Current Assignee: Ivax Corporation (Teva Pharmaceutical Industries, Ltd.)
• Original Assignee: Ivax Corporation (Teva Pharmaceutical Industries, Ltd.)
• Inventors: Barney, Brian
• Primary Examiner(s): Bianco; Patricia
• Assistant Examiner(s): PATEL, NIHIR B
• Application Number:
  US10/793,150
• Publication Number:
  US 20050081846A1
• Time in Patent Office: 1,447 Days
• Field of Search: 128/200.11, 128/200.12, 128/200.14, 128/200.16, 128/200.19, 12820021-20024, 128/202.22, 12820312-20315, 128/203.21, 128/203.23, 128/204.18, 128/205.23, 128/207.14, 116/200, 116/202, 116/279, 116/306, 239/338
• US Class Current: 128/200.23
• CPC Class Codes: A61M 15/0065 Inhalators with dosage or measuring devices A61M15/0028 takes precedence; dosage devices incorporated in aerosol cans B65D83/52
• CPC Class Codes: A61M 15/008 Electronic counters
• CPC Class Codes: A61M 15/009 using medicine packages with incorporated spraying means, e.g. aerosol cans pocket atomiser of the injector type A61M11/08
• CPC Class Codes: A61M 15/0091 mechanically breath-triggered
• CPC Class Codes: A61M 15/0096 Hindering inhalation before activation of the dispenser
• CPC Class Codes: G08B 5/36 using visible light sources

Abstract

A metered dose inhaler for use with a removable pressurized aerosol canister, or reservoir, having a display for indicating to a user the state of the canister. A memory device on the canister or a housing which houses the canister stores information indicative of doses dispensed from, or remaining in, the canister. That information is processed to provide and display information representative of the state of the canister.

Claims

1. A medicament inhaler assembly, comprising:

a housing defining a central void region disposed along a central axis;

a medicament container having an internal medicament containing reservoir, and extending along a container axis, and having at one end thereof, a dispensing port extending along said central axis, said dispensing port being coupled to said medicament containing reservoir, said medicament container containing a medicament disposed in said medicament containing reservoir, said medicament being in the form of a plurality of doses;

a dispensing means for dispensing said medicament from said medicament container, wherein in response to a user-induced motion said medicament container translates relative to said housing in a first direction along said central axis causing said medicament to be dispensed from said dispensing port;

an identification means for identifying said medicament container, said identification means configured for presenting information indicative of an identity of said container, wherein if said identity of said container is associated with said housing a first identifier is sent, and if said identity of said container is not associated with said housing a second identifier is sent;

a sleeve attached to said medicament container, wherein said identification means is attached to said sleeve;

a detector attached to said housing and adapted to detect said presented information from said identification means when said container is disposed in said central void region of said housing, wherein when said identification means sends said first identifier said detector generates a valid signal in response and when said identification means sends said second identifier said detector sends an invalid signal; and

a container state indicator assembly attached to said housing and said container, said container state indicator assembly including a detection means adapted for detecting a medicament dispensing motion of said medicament container relative to said housing, said container state indicator assembly further including a signaling means adapted for generating a signal indicative of a state of said medicament container.

2. The assembly according to claim 1, wherein said states of said medicament container include a first state and a second state.

3. The assembly according to claim 2, wherein said first state is indicative of said medicament containing reservoir containing at least a first predetermined number of doses, and said second state is indicative of said medicament containing reservoir containing less than said first predetermined number of doses.

4. The assembly according to claim 3, wherein said container state indicator assembly includes a graphic display device having an outer field with an inner void region and a medicament field disposed within said inner void region, wherein when said medicament containing reservoir includes at least said first predetermined number of doses said outer field and said medicament field are both turned on, and when said medicament containing reservoir includes less than said first predetermined number of doses only said outer field is turned on.

5. The assembly according to claim 4, wherein said outer field is container-shaped.

6. The assembly according to claim 4, wherein said outer field has a rectangular shape.

7. The assembly according to claim 4, wherein said outer field has a triangular shape.

8. The assembly according to claim 1, wherein said medicament container has one of at least three states.

9. The assembly according to claim 8, wherein said three states include a first state, a second state and a third state, wherein said first state is indicative of said medicament containing reservoir containing at least a first predetermined number of doses, said second state is indicative of said medicament containing reservoir containing fewer than said first predetermined number of doses but more than a second predetermined number of doses, said second state being a caution state, and said third state is indicative of said medicament containing reservoir containing fewer than said second predetermined number of doses.

10. The assembly according to claim 9, wherein said container state indicator assembly includes a graphic display device having an outer field defining an inner void region, and first and second medicament fields disposed within said inner void region of said outer field, wherein when said medicament containing reservoir includes at least said first predetermined number of doses said outer field and said first and second medicament fields are all turned on, when said medicament containing reservoir includes less than said first predetermined number of doses and more than said second predetermined number of doses said outer field and said first medicament field only are turned on, and when said medicament containing reservoir includes less than said second predetermined number of doses only said outer field is turned on.

11. The assembly according to claim 10, wherein said outer field is container-shaped.

12. The assembly according to claim 10, wherein said outer field has a rectangular shape.

13. The assembly according to claim 10, wherein said outer field has a triangular shape.

14. The assembly according to claim 1, wherein said container is an aerosol container.

15. The assembly according to claim 14, wherein said medicament is selected from a group consisting of ace-inhibitors, acne drugs, alkaloids, amino acid preparations, anabolic preparations, analgesics, anesthetics, antacids, antianginal drugs, anti-anxiety agents, anti arrhythmias, anti-asthmatics, antibiotics, anti-cholesterolemics, anti-coagulants, anti-convulsants, anti-depressants, anti-diabetic agents, anti-diarrhea preparations, antidotes, anti-emetics, anti-histamines, anti-hypertensive drugs, anti-inflammatory agents, anti-lipid agents, anti-manics, anti-nauseants, anti-nauseants, anti-neoplastics, anti-obesity drugs, anti-parkinsonism agents, anti-psychotics, anti-pyretics, anti-rheumatic agents, anti-spasmodics, anti-stroke agents, anti-thrombotic drugs, anti-thyriod preparations, anti-tumor drugs, anti-tussives, anti-ulcer agents, anti-uricemic drugs, anti-viral drugs, appetite stimulants or suppressants, biological response modifiers, blood modifiers, bone metabolism regulators, cardiovascular agents, central nervous system stimulates, cerebral dilators, cholinesterase inhibitors, contraceptives, coronary dilators, cough suppressants, decongestants, dietary supplements, diuretics, DNA and genetic modifying drugs, dopamine receptor agonists, endometriosis management agents, enzymes, erectile dysfunction therapies, erythropoietic drugs, expectorants, fertility agents, gastrointestinal agents, homeopathic remedies, hormones, hyper- and hypo-glycemic agents, hypercalcemia and hypocalcemia management agents, hypnotics, immunomodulators, immunosuppressives, ion exchange resins, laxatives, migraine preparations, motion sickness treatments, mucolytics, muscle relaxants, neuromuscular drugs, obesity management agents, osteoporosis preparations, oxytocics, parasympatholytics, parasympathomimetics, peripheral vasodilators, prostaglandins, psychotherapeutic agents, psycho-tropics, stimulants, respiratory agents, sedatives, smoking cessation aids, sympatholytics, systemic and non-systemic anti-infective agents, terine relaxants, thyroid and anti-thyroid preparations, tranquilizers, tremor preparations, urinary tract agents, vasoconstrictors, vasodilators, and combinations thereof.

16. The assembly according to claim 1, wherein said identification means includes an RFID device.

17. The assembly according to claim 1, wherein said detector is coupled to said identification means by a spring-loaded contact assembly, said spring-loaded contact assembly including fixed contacts attached to one of said housing and said medicament container, and including spring-loaded contacts attached to the other of said housing and said medicament container.

18. The assembly according to claim 1, wherein said container state indicator assembly is coupled to said medicament container by a spring-loaded contact assembly, said spring-loaded contact assembly including fixed contacts attached to one of said housing and said medicament container, and including spring-loaded contacts attached to the other of said housing and said medicament container.

19. The assembly according to claim 1, wherein said detector includes a display for indicating said valid or invalid signal generated by said detector.

20. The assembly according to claim 1, wherein said container state indicator assembly includes a display for indicating said signal generated by said container state indicator assembly.

21. The assembly according to claim 20, wherein said display is a liquid crystal display (LCD).

22. The assembly according to claim 20, wherein said display includes a light emitting diode (LED) device.

23. The assembly according to claim 20, wherein said display includes a switch, which turns on said display in response to said user-induced motion of said medicament container relative to said housing and then turns off said display after a relatively short period of time.

24. The assembly according to claim 20, wherein said display includes a switch with a control button accessible from an external surface of the assembly, wherein said switch turns on said display when a user depresses said control button and then turns off said display after a relatively short period of time.

25. The assembly according to claim 20, wherein said display includes a graphic display and a numeric display.

26. The assembly according to claim 1, wherein said sleeve is located proximate said dispensing port.

27. The assembly according to claim 1, wherein said sleeve is located at or near an intermediate portion of said container.

28. The assembly according to claim 1, wherein said sleeve includes at least one longitudinal rib and said housing defines at least one groove for receiving said at least one longitudinal rib to maintain a desired alignment of said medicament container in said housing.

29. The assembly according to claim 1, wherein said container state indicator assembly includes a memory device for saving the state of said medicament container.

30. The assembly according to claim 1, wherein said container state indicator assembly includes a switch assembly operatively connected to said medicament container and said housing, and a counter for counting the number of doses dispensed from said medicament container, wherein said medicament dispensing motion activates said switch assembly, which in turn activates said counter to count one unit.

31. The assembly according to claim 30, wherein said switch assembly includes a substantially U-shaped electrically conductive track attached to one of said medicament container and said housing, and two contacts attached to the other of said medicament container and said housing and electrically connected to said track, wherein a dispensing movement of said medicament container relative to said housing causes the length of said track between said two contacts to change, that in turn activates said counter to count one unit.

32. The assembly according to claim 30, wherein said switch assembly includes an inductive field generator attached to one of said medicament container and said housing, and an inductive detector attached to the other of said medicament container and said housing, wherein said inductive detector senses a movement of said inductive field generator relative to said inductive detector, and in turn activates said counter to count one unit.