Colonic cleansing composition and method

• US 7,332,184 B2
• Filed: 03/28/2003
• Issued: 02/19/2008
• Est. Priority Date: 03/28/2003
• Status: Expired due to Term

• Current Assignee: Queen's University At Kingston
• Original Assignee: Queen's University At Kingston
• Inventors: Barclay, Robert L., Depew, William T., Vanner, Stephen J.
• Primary Examiner(s): PAK, JOHN D
• Application Number:
  US10/401,505
• Publication Number:
  US 20040192614A1
• Time in Patent Office: 1,789 Days
• Field of Search: 424/606, 424/677, 424679-680, 514/23, 514/892
• US Class Current: 424/606
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/70 Carbohydrates; Sugars; Derivatives thereof sorbitol A61K31/047
• CPC Class Codes: A61K 33/00 Medicinal preparations containing inorganic active ingredients
• CPC Class Codes: A61K 33/42 Phosphorus; Compounds thereof
• CPC Class Codes: A61P 1/00 Drugs for disorders of the alimentary tract or the digestive system
• CPC Class Codes: A61P 3/12 for electrolyte homeostasis

Abstract

A colonic cleansing kit comprises an osmotic colonic evacuant, and an oral rehydration mixture. The oral rehydration mixture comprises sugar, and salt. The sugar comprises a glucose containing saccharide, and the salt comprises sodium.

Claims

1. A method of colonic cleansing in patients, comprising:

orally administering an osmotic colonic evacuant, wherein said evacuant comprises sodium phosphate; and

orally administering an oral rehydration solution;

wherein the oral rehydration solution comprises

(a) 5-7% (w/v) sugar mixture comprising sucrose, glucose and fructose,

(b) 10-200 mmol/L sodium containing salt, and

(c) water,

the patients maintain a fluid only diet for 24 hours prior to a colonoscopy, and at least 50% of all fluids orally administered from 4 hours before to 24 hours after orally administering the osmotic colonic evacuant are the oral rehydration solution.

2. The method of claim 1, wherein the orally administering of the osmotic colonic evacuant is after the orally administering of the oral rehydration solution.

3. The method of claim 1, wherein the oral rehydration solution further comprises a flavoring agent.

4. The method of claim 1, wherein the oral rehydration solution further comprises a coloring agent.

5. The method of claim 1, wherein the salt further comprises potassium.

6. The method of claim 1, wherein the oral rehydration solution further comprises a flavoring agent and potassium.

7. The method of claim 1, wherein the osmotic colonic evacuant is administered at a first time during a first day and a second time during the first day, and the administering of the oral rehydration solution is carried out from the first time to the morning of the next day.

8. The method of claim 7, wherein the first time is 5 PM.

9. The method of claim 7, wherein the second time is 10 PM.

10. The method of claim 7, wherein the colonoscopy on the patients is carried out during the next day.

11. The method of claim 1, wherein the administering of the oral rehydration solution is carried out from 5 PM during a day to the morning of the next day.

12. The method of claim 11, wherein the colonoscopy on the patients is carried out during the next day.

13. The method of claim 1, wherein the oral rehydration solution has a concentration of said salt of 10-30 mmol/L.

14. The method of claim 13, wherein the salt further comprises potassium.

15. The method of claim 1, wherein at least 90% of all fluids orally administered from 4 hours before to 24 hours after orally administering the osmotic colonic evacuant are the oral rehydration solution.

16. The method of claim 1, wherein the patients have statistically significant superior bowel colonic cleansing, as compared to other patients who consumed only clear fluids, and

the clear fluids comprise water, juices and/or carbonated beverages, and do not comprise commercial sports drinks.

17. The method of claim 1, wherein the oral rehydration solution consists essentially of 6% (w/v) said sugar mixture, 20 mmol/L sodium, 3 mmol/L potassium and water.