Feature quantification from multidimensional image data
First Claim
1. A method for assessing an imaged subject, the method comprising the steps of:
- obtaining imaging data of said imaged subject, said imaging data being representative of an extensional feature of said imaged subject;
applying direct quantitative analysis to said imaging data to determine at least one parameter value of said extensional feature, andgenerating an output signal representative of the determined parameter value of said extensional feature;
the step of applying quantitative analysis further comprising the steps of selecting an imaging data set corresponding to a selected region of said imaged subject, identifying a spatially varying function, that is representative of the cross section of extensional feature in said imaging data set, the spatially varying function comprising non-circular functions and families of profiles, said profiles comprising Gaussian functions and ellipsoid functions and generating said at least one parameter value from the identified spatially varying function.
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Abstract
Techniques, hardware, and software are provided for quantification of extensional features of structures of an imaged subject from image data representing a two-dimensional or three-dimensional image. In one embodiment, stenosis in a blood vessel may be quantified from volumetric image data of the blood vessel. A profile from a selected family of profiles is fit to selected image data. An estimate of cross sectional area of the blood vessel is generated based on the fit profile. Area values may be generated along a longitudinal axis of the vessel, and a one-dimensional profile fit to the generated area values. An objective quantification of stenosis in the vessel may be obtained from the area profile. In some cases, volumetric image data representing the imaged structure may be reformatted to facilitate the quantification, when the structural feature varies along a curvilinear axis. A mask is generated for the structural feature to be quantified based on the volumetric image data. A curve representing the curvilinear axis is determined from the mask by center-finding computations, such as moment calculations, and curve fitting. Image data are generated for oblique cuts at corresponding selected orientations with respect to the curvilinear axis, based on the curve and the volumetric image data. The oblique cuts may be used for suitable further processing, such as image display or quantification.
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Citations
21 Claims
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1. A method for assessing an imaged subject, the method comprising the steps of:
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obtaining imaging data of said imaged subject, said imaging data being representative of an extensional feature of said imaged subject; applying direct quantitative analysis to said imaging data to determine at least one parameter value of said extensional feature, and generating an output signal representative of the determined parameter value of said extensional feature; the step of applying quantitative analysis further comprising the steps of selecting an imaging data set corresponding to a selected region of said imaged subject, identifying a spatially varying function, that is representative of the cross section of extensional feature in said imaging data set, the spatially varying function comprising non-circular functions and families of profiles, said profiles comprising Gaussian functions and ellipsoid functions and generating said at least one parameter value from the identified spatially varying function. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
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12. A method for determining the lumen in a vessel in a body, the method comprising the steps of:
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obtaining imaging data of said vessel comprising a plurality of imaging data sets representative of respective imaging slices through said vessel; determining a three-dimensional representation of the longitudinal axis of said vessel; computing an orthogonal cross section data set for each of a plurality of respective positions along said longitudinal axis of said vessel; wherein the step of determining a three-dimensional representation of the longitudinal axis of said vessel further comprises the steps of computing the lumen center point in selected ones of said imaging slices, wherein computing the lumen center point further comprises generating a mask for a region of interest encompassing said vessel; computing a lumen area for each of said respective orthogonal cross section data sets; and generating respective signals representative of said lumen areas associated with points along said longitudinal axis. - View Dependent Claims (13, 14, 15, 16, 17, 18, 19, 20, 21)
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Specification