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Unified probabilistic framework for predicting and detecting seizure onsets in the brain and multitherapeutic device

  • US 7,333,851 B2
  • Filed: 09/12/2003
  • Issued: 02/19/2008
  • Est. Priority Date: 10/20/2000
  • Status: Expired due to Term
First Claim
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1. A system for automatically predicting and preventing the electrographic onset of a seizure in an individual, comprising:

  • a signal acquisition component to condition and digitize a plurality of raw signals received from a transducer implanted in the individual;

    a preprocessor to attenuate any artifacts in the plurality of digitized signals;

    a feature extraction component containing processing logic to select patient-specific seizure-predictive and seizure-indicative attributes from the preprocessed signals to form an optimal feature vector;

    a probability estimator component that synthesizes a probability vector as an estimator of the likelihood of seizure for a plurality of prediction times;

    a multitherapy activation component containing processing logic to determine the therapy modalities that are to be activated or deactivated at any time; and

    an implanted device including a plurality of therapy actuators to automatically activate at least one associated therapy in response to an output signal from the multitherapy activation component.

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