Pulse burst electrical stimulation of nerve or tissue fibers

• US 7,333,858 B2
• Filed: 03/30/2005
• Issued: 02/19/2008
• Est. Priority Date: 03/31/2004
• Status: Expired due to Fees

• Current Assignee: Cochlear Limited
• Original Assignee: Cochlear Limited
• Inventors: von Wallenberg, Ernst, Smoorenburg, Guido, Killian, Matthijs
• Primary Examiner(s): Layno; Carl
• Assistant Examiner(s): Patel; Natasha
• Application Number:
  US11/092,771
• Publication Number:
  US 20050222644A1
• Time in Patent Office: 1,056 Days
• Field of Search: 607/55, 607/57, 607/60, 607/137, 607/66, 607/68, 607/70, 607/72, 600/379
• US Class Current: 607/56
• CPC Class Codes: A61N 1/36038 Cochlear stimulation

Abstract

A method for stimulating nerve or tissue fibers and a prosthetic hearing device implanting same. The method comprises: generating a stimulation signal comprising a plurality of pulse bursts each comprising a plurality of pulses; and distributing said plurality of pulse bursts across one or more electrodes each operatively coupled to nerve or tissue fibers such that each of said plurality of pulse bursts delivers a charge to said nerve or tissue fibers to cause dispersed firing in said nerve or tissue fibers.

Claims

1. A method of stimulating auditory nerve fibers comprising:

generating a stimulation signal comprising a plurality of pulse bursts, each said pulse burst comprising a succession of pulses, wherein at least one of said successive pulses and its immediate preceding pulse have at least one parameter that is different;

distributing a selected pulse burst from said plurality of pulse bursts to a selected electrode of one or more electrodes operatively coupled to a selected group of auditory nerve fibers wherein the at least one different parameter causes said succession of pulses to deliver a charge to the auditory nerve fibers that causes firings in the auditory nerve fibers that are substantially stochastic in time and dispersed along the auditory nerve fibers, wherein the firings occur at substantially normal physiological rates and wherein said plurality of pulse bursts are separated in one or more of space and time to provide substantially normal recovery periods.

2. The method of claim 1, wherein said generating said stimulation signal comprises:

generating said stimulation signal in accordance with an implemented speech processing strategy.

3. The method of claim 2, wherein said implemented speech processing strategy comprises an implemented low-rate speech processing strategy.

4. The method of claim 3, wherein said stimulation signal has a pulse rate of less than approximately 500 pulses per second.

5. The method of claim 1, wherein one or more of the plurality of pulse bursts is a ramped pulse burst.

6. The method of claim 5, wherein said ramped pulse burst has an approximate linear intensity function.

7. The method of claim 6, wherein said approximate linear intensity function of said ramped pulse burst is a linearly increasing intensity function.

8. The method of claim 7, wherein said linearly increasing intensity function of said ramped pulse burst is progressively increasing across successively occurring ramped pulse bursts.

9. The method of claim 5, wherein said ramped pulse burst has an approximate exponential intensity function.

10. The method of claim 5, wherein said ramped pulse burst has a staggered intensity function.

11. The method of claim 1, wherein one or more successive pulses of said succession of pulses comprise a biphasic pulse.

12. The method of claim 1, wherein one or more successive pulses of said succession of pulses comprise a monophasic pulse.

13. The method of claim 1, wherein one or more successive pulses of said succession of pulses have a substantially square waveform.

14. The method of claim 1, wherein one or more successive pulses of said succession of pulses have a substantially sinusoidal waveform.

15. The method of claim 1, wherein one or more successive pulses of said succession of pulses have a substantially sawtooth waveform.

16. The method of claim 1, wherein said at least one different parameter comprises a duration.

17. The method of claim 1, wherein said least one different parameter comprises an amplitude.

18. The method of claim 1, further comprising:

distributing said plurality of pulse bursts across said one or more electrodes such that said succession of pulses of at least one of said plurality of pulse bursts occurring on said selected electrode are interleaved with said succession of pulses of at least one other of said plurality of pulse bursts occurring on a different electrode of said one or more electrodes.

19. The method of claim 18, wherein distributing said plurality of pulse bursts across said one or more electrodes comprises:

distributing said plurality of pulse bursts across said selected and different electrode such that said succession of pulses of said at least one of said plurality of pulse bursts are repeatedly interleaved with said succession of pulses of said at least one other of said plurality of pulse bursts.

20. The method of claim 1, wherein said plurality of pulses bursts is sequentially distributed on said one or more electrodes.

21. The method of claim 1, wherein at least two successive pulses of the succession of pulses are simultaneously distributed on two or more of said one or more electrodes.

22. The method of claim 1, wherein distributing said plurality of pulse bursts to enhance-temporal cues when stimulating said auditory nerve fibers.

23. The method of claim 22, wherein said one or more electrodes comprises one or more high frequency electrodes and one or more low frequency electrodes each operatively coupled to said auditory nerve fibers which responds to high frequency stimulation signals or low frequency stimulation signals, respectively, and

wherein a first portion of said plurality of pulse bursts are distributed on said one or more low frequency electrodes and a second portion of said plurality of pulse bursts are distributed on said one or more high frequency electrodes.

24. The method of claim 23, wherein said one or more low frequency electrodes are operatively coupled to said auditory nerve fibers that respond to stimulation below 500 Hz.

25. The method of claim 23, wherein said one or more high frequency electrodes are operatively coupled to said auditory nerve fibers that respond to stimulation above 500 Hz.

26. The method of claim 23, wherein said first portion of said plurality of pulse bursts have a longer duration than said second portion of said plurality of pulses bursts.

27. The method of claim 23, wherein said first portion of said plurality of pulse bursts have a longer interval than said second portion of said plurality of pulses bursts.

28. The method of claim 23, wherein said succession of pulses of said first portion of said plurality of pulse bursts have a longer duration than said succession of pulses of said second portion of said plurality of pulses bursts.

29. A method of stimulating nerve fibers using electrodes operatively coupled to the nerve fibers comprising:

generating a stimulation signal comprising a first plurality of pulse bursts having a first duration and a second plurality of pulse bursts having a second duration that is less than said first duration, wherein the first plurality of pulse bursts comprises a first succession of pulses having at least one different first parameter for each successive pulse, and wherein the second plurality of pulse bursts comprises a second succession of pulses having at least one different second parameter for each successive pulse;

distributing said first plurality of pulse bursts across one or more of said electrodes operatively coupled to first nerve fibers responsive to low frequency stimulation such that the at least one different first parameter of each said successive pulse causes said first succession of pulses to deliver a first charge to said first nerve fibers, wherein said first charge causes stochastic and dispersed firing in said first nerve fibers; and

distributing said second plurality of pulse bursts across one or more of said electrodes operatively coupled to second nerve fibers responsive to high frequency stimulation such that the at least one different second parameter of each said successive pulse causes said second succession of pulses to deliver a second charge to said second nerve fibers, wherein said second charge causes stochastic and dispersed firing in said second nerve fibers.

30. The method of claim 29, wherein the first and second nerve fibers are auditory nerve fibers.

31. The method of claim 29, wherein said first nerve fibers responsive to low frequency stimulation are responsive to stimulation below 500 Hz.

32. The method of claim 29, wherein said second nerve fibers responsive to high frequency stimulation are responsive to stimulation above 500 Hz.

33. The method of claim 29, wherein a speech processor implementing a low-rate speech processing strategy generates said stimulation signal.

34. The method of claim 29, wherein one or more of said first plurality of pulse bursts is ramped.

35. A prosthetic hearing device, comprising:

means for generating a stimulation signal from an ambient sound;

means for defining one or more pulse bursts in said stimulation signal, each of the one or more pulse bursts comprising a succession of pulses, wherein at least one of said successive pulses and its immediate preceding pulse have at least one parameter that is different;

means for distributing a selected pulse burst from said pulse bursts to a selected electrode from one or more electrodes operatively coupled to a selected group of auditory nerve fibers, wherein the at least one different parameter causes said succession of pulses to deliver a charge to the auditory nerve fibers that causes firings in the nerve fibers that are substantially stochastic in time and dispersed along the auditory nerve fibers, wherein the firings occur at substantially normal physiological rates and wherein said plurality of pulse bursts are separated in one or more of space and time to provide substantially normal recovery periods.

36. The prosthetic hearing device of claim 35, wherein the one or more pulse bursts each is a ramped pulse burst.

37. The prosthetic hearing device of claim 35, wherein the nerve fibers are auditory nerve fibers.

38. The prosthetic hearing device of claim 35, wherein said means for distributing said pulse bursts across one or more electrodes comprises:

means for distributing a first plurality of said one or more pulse bursts across one or more electrodes operatively coupled to nerve fibers responsive to low frequency stimulation; and

means for distributing a second plurality of said one or more pulse bursts across one or more electrodes operatively coupled to nerve fibers responsive to high frequency stimulation.

39. The prosthetic hearing device of claim 38, wherein said nerve fibers responsive to low frequency stimulation are responsive to stimulation below 500 Hz, and said nerve fibers responsive to high frequency stimulation are responsive to stimulation above 500 Hz.