Multiple function airway adapter

• US 7,335,164 B2
• Filed: 04/24/2001
• Issued: 02/26/2008
• Est. Priority Date: 07/15/1996
• Status: Expired due to Fees

• Current Assignee: RIC INVESTMENTS LLC (Koninklijke Philips N.V.)
• Original Assignee: NTC Technology, Inc. (Dixtal Medical, Inc.)
• Inventors: Kofoed, Scott A., Labuda, Lawrence L., Blazewicz, Perry R., Mace, Leslie E., Orr, Joseph A., Jaffe, Michael B., Rich, David R.
• Primary Examiner(s): Nasser; Robert L.
• Application Number:
  US09/841,451
• Publication Number:
  US 20020029003A1
• Time in Patent Office: 2,499 Days
• Field of Search: 600/532, 73/233, 432/84
• US Class Current: 600/532
• CPC Class Codes: A61B 5/083 Measuring rate of metabolism by using breath test, e.g. measuring rate of oxygen consumption
• CPC Class Codes: A61B 5/0833 Measuring rate of oxygen consumption
• CPC Class Codes: A61B 5/087 Measuring breath flow
• CPC Class Codes: A61B 5/097 Devices for facilitating collection of breath or for directing breath into or through measuring devices
• CPC Class Codes: G01F 1/40 Details of construction of the flow constriction devices
• CPC Class Codes: G01F 1/42 Orifices or nozzles
• CPC Class Codes: G01N 2001/2244 Exhaled gas, e.g. alcohol detecting
• CPC Class Codes: G01N 2021/6432 Quenching
• CPC Class Codes: G01N 21/0303 Optical path conditioning in cuvettes, e.g. windows; adapted optical elements or systems; path modifying or adjustment G01N21/031 - G01N21/15 take precedence
• CPC Class Codes: G01N 21/05 Flow-through cuvettes G01N21/09 takes precedence; handling fluid samples G01N1/10
• CPC Class Codes: G01N 21/3504 for analysing gases, e.g. multi-gas analysis
• CPC Class Codes: G01N 21/6428 Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" in vivo A61B5/00; immunoassay G01N33/53
• CPC Class Codes: G01N 21/645 Specially adapted constructive features of fluorimeters
• CPC Class Codes: G01N 33/0036 specially adapted to detect a particular component physical analysis of gaseous biological material G01N33/497
• CPC Class Codes: G01N 33/497 of gaseous biological material, e.g. breath

Abstract

An integrated airway adapter capable of monitoring any combination of respiratory flow, O₂ concentration, and concentrations of one or more of CO₂, N₂O, and an anesthetic agent in real time, breath by breath. Respiratory flow may be monitored with differential pressure flow meters under diverse inlet conditions through improved sensor configurations which minimize phase lag and dead space within the airway. Molecular oxygen concentration may be monitored by way of luminescence quenching techniques. Infrared absorption techniques may be used to monitor one or more of CO₂, N₂O, and anesthetic agents.

Claims

1. An airway adapter configured to substantially simultaneously provide data indicative of respiratory gas flow and of a concentration of at least two substances present in respiration of an individual, comprising:

a housing with a bore formed therethough;

a respiratory flow detection component formed in the housing and in communications with the bore;

a first respiratory detection component configured to facilitate sensing of at least a first of the at least two substances without diverting respiratory gases from the housing and comprising a detection chamber within the housing, a boundary of the detection chamber at least partially defined by at least one window; and

a second respiratory detection component disposed on at least a portion of the at least one window and comprising at least one luminescence quenching sensor configured to facilitate sensing of at least a second of the at least two substances without diverting respiratory gases from the housing.

2. The airway adapter of claim 1, wherein the respiratory flow detection component comprises:

a structure within said housing for creating therein a pressure differential in respiratory gas flow; and

first and second pressure bores formed in the housing and located so as to facilitate detection of the pressure differential.

3. The airway adapter of claim 2, wherein the structure for creating the pressure differential comprises at least one strut.

4. The airway adapter of claim 3, wherein the first and second pressure bores are at least partially formed within the at least one strut.

5. The airway adapter of claim 4, wherein said at least one strut comprises a restriction member with at least one surface oriented so as to substantially perpendicularly face a direction of respiratory gas flow through the housing.

6. The airway adapter of claim 5, wherein the restriction member has a disk shape.

7. The airway adapter of claim 5, wherein the at least one strut includes a taper oriented toward the detection chamber.

8. The airway adapter of claim 4, wherein said at least one strut is diametrically disposed and longitudinally extends within said bore.

9. The airway adapter of claim 8, wherein the first and second pressure bores communicate respectively with laterally spaced first and second notches formed in the at least one strut proximate a longitudinal axis of the housing.

10. The airway adapter of claim 9, wherein the first and second notches are oriented substantially perpendicularly relative to a length of the at least one strut.

11. The airway adapter of claim 1, wherein the boundary of the detection chamber is at least partially defined by opposed windows.

12. The airway adapter of claim 1, wherein the at least one window is optically compatible so as to permit a beam of infrared radiation to traverse the detection chamber.

13. The airway adapter of claim 1, wherein the first respiratory detection component is configured to facilitate measurement of at least one of CO₂, N₂O, and an anesthetic agent.

14. The airway adapter of claim 1, wherein the first respiratory detection component and the second respiratory detection component include at least one common element.

15. The airway adapter of claim 1, wherein the at least one window is formed from a polymer.

16. The airway adapter of claim 15, wherein the polymer comprises a biaxially oriented polypropylene.

17. The airway adapter of claim 1, wherein the respiratory flow detection component comprises first and second pressurization ports positioned on opposite sides of the detection chamber.

18. The airway adapter of claim 1, wherein the respiratory flow detection component comprises first and second pressurization ports formed in the housing on the same side of the detection chamber.

19. A respiratory monitoring system, comprising:

an airway adapter, comprising;

a housing with a flow passage extending therethough;

a first window positioned on top of the housing for facilitating luminescence quenching measurements of at least one substance within the flow passage;

a luminescable material disposed in communication with the flow passage and adjacent the first window;

a pair of second windows positioned on sides of the housing on opposite sides of the flow passage for facilitating infrared measurements of at least another substance within the flow passage; and

a transducer-orienting element; and

a transducer, comprising;

an attachment feature configured to secure the transducer to the airway adapter, with the transducer-orienting element of the airway adapter defining an orientation of the transducer and a plurality of features thereof with the airway adapter such that luminescence quenching measurements are made through the first window and infrared measurements are made through the second windows.

20. The respiratory monitoring system of claim 19, wherein a membrane carrying the luminescable material is disposed on an inside of the first window.

21. The respiratory monitoring system of claim 19, wherein the transducer-orienting element is configured to orient a radiation source and luminescence detector of the transducer toward the first window, an infrared source of the transducer toward one second window of the pair, and an infrared detection component of the transducer toward another second window of the pair.

22. The respiratory monitoring system of claim 19, further comprising a respiratory flow detection component located along another position of the flow passage than positions of the first window and the pair of second windows.

23. A respiratory monitoring system, comprising:

an airway adapter, comprising;

a housing including;

a flow passage extending through at least a portion of a length thereof; and

a transducer orienting element comprising seat for receiving a complementarily configured portion of a transducer;

a transducer comprising;

a radiation source and a luminescence detector to make luminescence quenching measurement;

an infrared source and an infrared detector to make additional measurements;

a first window in the housing for facilitating luminescence quenching measurements of at least one substance in the flow passage the seat of the housing orienting the radiation source and the luminescence detector of the transducer toward the first window;

a luminescence material disposed in communications with the flow passage and adjacent the first window;

a second window in the housing for facilitating infrared measurements of at least another substances in the flow passage the seat of the housing orienting the infrared source and the infrared detection component of the transducer toward the second window; and

an attachment feature that secures the transducer to the transducer-orienting element of the airways adapter, with the transducer-orienting element defining an orientation of the transducer and a plurality of features thereof with the airway adapter.

24. The respiratory monitoring system of claim 23, wherein a membrane carrying the luminescable material is disposed on an inside of the first window.

25. The respiratory monitoring system of claim 23, wherein the first window is positioned on a top of the housing.

26. The respiratory monitoring system of claim 23, wherein the second window is positioned on a side of the housing.

27. The respiratory monitoring system of claim 23, further comprising a respiratory flow detection component located along another position of the flow passage than positions of the first window and the pair of second windows.

28. A respiratory monitoring system, comprising:

an airway adapter, comprising;

a housing with flow passage extending therethough, the housing including;

a transducer-orienting element comprising a seat that receives a complementarily configured portion of a transducer;

a first window in the housing for facilitating luminescence quenching measurements of at least one substance within the flow passage a luminescence material disposed in communication with the flow passage and adjacent the first window;

a pair of second windows positioned in the housing on opposite sides of the flow passage for facilitating infrared measurements of at least another substance within the flow passage;

a transducer, comprising;

a radiation source and a luminescence detector for making luminescence quenching measurements;

an infrared source and an infrared detector for making additional measurements; and

an attachment feature securing the transducer to the transducer-orienting element, with the seat of the transducer-orienting element of the airway adapter defining an orientation of the transducer and orienting;

the radiation source and the luminescence detector toward the first window;

the infrared source toward one second window of the pair, and the infrared detection component of the transducer toward another second window of the pair.

29. The airway adapter of claim 28, wherein a membrane carrying the luminescence material is disposed on an inside of the first window.

30. The airway adapter of claim 28, further comprising a respiratory flow detection component located along another position of the flow passage than positions of the first window and the pair of second windows.

31. A respiratory monitoring system, comprising:

an airway adapter, comprising;

housing including a flow a passage extending through at least a portion of a length thereof;

a first window positioned on top of the housing for facilitating luminescence quenching measurements of at least one substance in the flow passage

a luminescence material disposed in communication with the flow passage and adjacent the first window;

a second window positioned on a side of the housing for facilitating infrared measurements of at least another substance in the flow passage;

a transducer-orienting element;

a transducer_comprising;

a first device for making luminescence quenching measurements through the first window;

a second device for making infrared measurements through the second window;

and an attachment feature securing the transducer to the transducer-orienting element of the airway adapter, with the transducer-orienting element defining an orientation of the transducer and a plurality of features thereof with the airway adapter.

32. The airway adapter of claim 31, wherein a membrane carrying the luminescence material is disposed on an inside of the first window.

33. The airway adapter of claim 31, further comprising:

a respiratory flow detection component located along another position of the flow passage than positions of the first window and the pair of second windows.

34. An airway adapter configured to substantially simultaneously provide data indicative of respiratory gas flow and of concentration of at least two substances present in respiration of an individual, comprising:

a housing with a bore formed therethough and a detection chamber positioned along the bore;

a respiratory flow detection component formed in the housing, in communication with a bore, and comprising first and second pressurization ports positioned on opposite sides of the detection chamber;

a first respiratory detection component configured to facilitate sensing of at least a first of the at least two substances without diverting respiratory gases from the housing and comprising the detection chamber, a boundary of the detection chamber at least partially defined by at least one window, and

a second respiratory detection component comprising at least one luminescence quenching sensor configured to facilitate sensing of at least a second of the at least two substances without diverting respiratory gases from the housing.

35. The airway adapter of claim 34, wherein the respiratory flow detection component comprises:

a structure within the housing for creating therein a pressure differential in respiratory gas flow; and

first and second pressure bores formed in the housing and located so as to facilitate detection of the pressure differential.

36. The airway adapter of claim 35, wherein the structure for creating the pressure differential comprises at least one strut.

37. The airway adapter of claim 36, wherein the first and second pressure bores are at least partially formed within the at least one strut.

38. The airway adapter of claim 37, wherein the at least one strut comprises a restriction member with at least one surface oriented so as to substantially perpendicularly face a direction of respiratory gas flow through the housing.

39. The airway adapter of claim 38, wherein the restriction member has a disk shape.

40. The airway adapter of claim 38, wherein the at least one strut includes a taper oriented toward the detection chamber.

41. The airway adapter of claim 37, wherein the at least one strut is diametrically disposed and longitudinally extends within the bore.

42. The airway adapter of claim 41, wherein the first and second pressure bores communicate respectively with laterally spaced first and second notches formed in the at least one strut proximate a longitudinal axis of the housing.

43. The airway adapter of claim 42, wherein the first and second notches are oriented substantially perpendicularly relative to a length of the at least one strut.

44. The airway adapter of claim 34, wherein the boundary of the detection chamber is at least partially defined by opposed windows.

45. The airway adapter of claim 34, wherein the at least one window is optically compatible so as to permit a beam of infrared radiation to traverse the detection chamber.

46. The airway adapter of claim 34, wherein the first respiratory detection component is configured to facilitate measurement of at least one of CO₂, N₂O, and an anesthetic agent.

47. The airway adapter of claim 34, wherein the first respiratory detection component and the second respiratory detection component include at least one common element.

48. The airway adapter of claim 34, wherein the at least one window is formed from a polymer.

49. The airway adapter of claim 48, wherein the polymer comprises a biaxially oriented polypropylene.

50. The airway adapter of claim 34, wherein the respiratory flow detection component comprises first and second pressurization ports positioned on opposite sides of the detection chamber.

51. The airway adapter of claim 34, wherein the respiratory flow detection component comprises first and second pressurization ports formed in the housing on the same side of the detection chamber.