Causative agent of the Mystery Swine Disease, vaccine compositions and diagnostic kits
First Claim
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1. A method of producing an immunogenic composition, the method comprising:
- introducing a purified preparation containing a polynucleotide encoding at least one polypeptide encoded by one or more open reading frames (ORFs) of ORFs 1-7 of a mystery swine disease virus, wherein the mystery swine disease virus is the isolate Lelystad Agent (CDI-NL-2.91) deposited Jun. 5, 1991 with the Institut Pasteur, Collection Nationale de Cultures De Microorganismes (C.N.C.M.) 25, rue du Docteur Roux, 75724--Paris Cedex 15, France, deposit number I-1102, into a suitable host cell;
culturing said suitable host cell; and
isolating one of the following therefrom;
a suitable host cell containing said polypeptide;
virus;
viral protein;
viral polynucleic acid;
or mixtures thereof.
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Abstract
Composition of matter comprising the causative agent of Mystery Swine Disease, Lelystad Agent, in a live, attenuated, dead, or recombinant form, or a part or component of it. Vaccine compositions and diagnostic kits based thereon. Recombinant nucleic acid comprising a Lelystad Agent-specific nucleotide sequence. Peptides comprising a Lelystad Agent-specific amino acid sequence. Lelystad Agent-specific antibodies.
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5 Claims
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1. A method of producing an immunogenic composition, the method comprising:
- introducing a purified preparation containing a polynucleotide encoding at least one polypeptide encoded by one or more open reading frames (ORFs) of ORFs 1-7 of a mystery swine disease virus, wherein the mystery swine disease virus is the isolate Lelystad Agent (CDI-NL-2.91) deposited Jun. 5, 1991 with the Institut Pasteur, Collection Nationale de Cultures De Microorganismes (C.N.C.M.) 25, rue du Docteur Roux, 75724--Paris Cedex 15, France, deposit number I-1102, into a suitable host cell;
culturing said suitable host cell; and
isolating one of the following therefrom;
a suitable host cell containing said polypeptide;
virus;
viral protein;
viral polynucleic acid;
or mixtures thereof. - View Dependent Claims (2, 3, 4, 5)
- introducing a purified preparation containing a polynucleotide encoding at least one polypeptide encoded by one or more open reading frames (ORFs) of ORFs 1-7 of a mystery swine disease virus, wherein the mystery swine disease virus is the isolate Lelystad Agent (CDI-NL-2.91) deposited Jun. 5, 1991 with the Institut Pasteur, Collection Nationale de Cultures De Microorganismes (C.N.C.M.) 25, rue du Docteur Roux, 75724--Paris Cedex 15, France, deposit number I-1102, into a suitable host cell;
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