Amino ceramide-like compounds and therapeutic methods of use
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Abstract
Novel prodrugs of amino ceramide-like compounds are provided which inhibit glucosyl ceramide (GlcCer) formation by inhibiting the enzyme GlcCer synthase, thereby lowering the level of glycosphingolipids. The compounds of the present invention have improved GlcCer synthase inhibition activity and are therefore highly useful in therapeutic methods for treating various conditions and diseases associated with altered glycosphingolipid levels.
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12 Claims
- 1. A compound represented by the formula:
- 6. A compound selected from the group consisting of the formula:
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11. A compound selected from the group consisting of the formulas:
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12. A method for treating a patient having Gaucher'"'"'s disease, Tay Sachs disease, Fabry'"'"'s disease. Sandhoff disease or GM1 gangliosidosis, comprising the step of administering to the patient a therapeutically effective amount of a compound selected from the group consisting of the formulas:
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