Breast cancer detection system

• US 7,340,292 B2
• Filed: 02/13/2004
• Issued: 03/04/2008
• Est. Priority Date: 02/14/2003
• Status: Active Grant

• Current Assignee: University of Florida Research Foundation, Incorporated (State University System of Florida)
• Original Assignee: University of Florida Research Foundation, Incorporated (State University System of Florida)
• Inventors: Li, Jian
• Primary Examiner(s): Casler; Brian L.
• Assistant Examiner(s): RAMIREZ, JOHN FERNANDO
• Application Number:
  US10/778,973
• Publication Number:
  US 20040167399A1
• Time in Patent Office: 1,481 Days
• Field of Search: 600/407, 600/430
• US Class Current: 600/430
• CPC Class Codes: A61B 5/05 Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves impedance plethysmography A61B5/0295; measuring movement of the entire body or parts thereof A61B5/11; detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof A61B5/24
• CPC Class Codes: A61B 5/0507 using microwaves or terahertz waves

Abstract

A method for detecting breast cancer can include the step of positioning a transmitting antenna and a receiving antenna about a breast so that the transmitting antenna is positioned to transmit microwave energy into the breast and the receiving antenna is positioned to receive the transmitted energy after the energy has passed into the breast. Microwave energy can be transmitted from the transmitting antenna. The microwave energy can be received by the receiving antenna and used to determine a presence of tumors within the breast. A relative position of the transmitting antenna and the receiving antenna can be adjusted about the breast. After each position adjustment, the transmitting and the receiving steps can be repeated.

Claims

1. A method for detecting breast cancer comprising the steps of:

coupling a plurality of transmitting antennas to surface portions of a breast and transmitting microwave energy from each of said transmitting antennas, each of the transmitting antennas being moveable to accommodate a shape and size of said breast;

coupling a plurality of receiving antennas to different surface portions of the breast and receiving reflected microwave energy via each of said receiving antennas, each of the receiving antennas being moveable to accommodate a shape and size of said breast;

positioning a passive array of antennas at a location remote from said transmitting and receiving antennas to detect the transmitted microwave energy;

recording arrival times corresponding to when each antenna of the passive array of antennas detects the transmitted microwave energy and computing based upon the recorded arrival times a corresponding differential arrival time of the transmitted microwave energy at each antenna of the passive array;

computing relative positions of the plurality of transmitting antennas and the plurality of receiving antennas based upon differential arrival times;

adjusting a relative position of at least one of said transmitting antennas and said receiving antennas on said breast; and

repeating said transmitting and said receiving steps after adjusting said relative position, wherein the received microwave energy is used to determine a presence of tumors within said breast.

2. The method of claim 1, wherein said transmitted step transmits ultrawideband microwave energy using a stepped frequency transmission technique.

3. The method of claim 1, performing said adjusting and said repeating steps a plurality of times to generate a composite scan of said breast.

4. The method of claim 1, further comprising the steps of:

displaying an image of said breast using microwave imaging based upon said received microwave energy; and

applying an auto-focusing technique to mitigate blurring of said image.

5. The method of claim 1, further comprising the steps of:

displaying an image of said breast using microwave imaging based upon said received microwave energy; and

applying a spectral estimation technique to said image.

6. The method of claim 1, further comprising the step of:

reducing clutter attributable to a boundary between breast tissue and adjacent tissue using a time delay estimation technique, wherein said time delay estimation technique utilizes a weighted Fourier transformation and Lagrangian relaxation algorithm.

7. A system for detecting breast cancer comprising:

a plurality of microwave transmitting antennas configured to be attached to respective surface portions of a breast to transmit microwave energy into said breast, each of the transmitting antennas being moveable to accommodate a shape and size of said breast;

a plurality of receiving antennas configured to be attached to respective surface portions of said breast to receive microwave energy reflected from said breast, each of the receiving antennas being moveable to accommodate a shape and size of said breast;

a passive array of antennas positioned at a location remote from said transmitting and receiving antennas to detect the transmitted microwave energy;

a processor to compute a differential arrival time of the transmitted microwave energy at each antenna of the passive array based upon recorded arrival times corresponding to when each antenna of the passive array of antennas detects the transmitted microwave energy, and to compute relative positions of the plurality of transmitting antennas and the plurality of receiving antennas based upon the differential arrival times;

a signal processor configured to determine a presence of a tumor within said breast based upon computations involving microwave energy transmitted by said transmitting antenna, microwave energy received by said receiving antenna, and the relative positions of said transmitting antenna and said receiving antenna.

8. The system of claim 7, wherein said transmitting antenna and said receiving antenna are independently positionable on said breast.

9. The system of claim 7, further comprising:

a microwave imaging system configured to display an interior image of said breast based upon microwave energy detected by the receiving antenna.

10. A system for detecting breast cancer comprising:

a plurality of transmitting antennas configured to be attached to respective surface portions of a breast to transmit microwave energy into the breast, each of the transmitting antennas being moveable to accommodate a shape and size of said breast;

a plurality of receiving antennas configured to be attached to different respective surface portions of the breast to receive microwave energy reflected from the breast, each of the receiving antennas being moveable to accommodate a shape and size of said breast;

a passive array of antennas positioned at a location remote from said transmitting and receiving antennas to detect the transmitted microwave energy;

a means for determining differential arrival times of the transmitted microwave energy at each antenna of the passive array based upon when each antenna of the passive array of antennas detects transmitted microwave energy and for positioning said transmitting antennas and said receiving antennas on said breast so that said transmitting antennas are positioned to transmit microwave energy into said breast and said receiving antennas are positioned to receive said transmitted energy after said energy has passed into said breast, the positioning of said transmitting and receiving antennas being based upon the determined differential arrival times;

a means for adjusting a relative position of said transmitting antenna and said receiving antenna on said breast to generate a composite scan of said breast;

a means for determining a presence of tumors within said breast that utilizes repeated microwave transmissions, said transmissions occurring with said transmitting antenna and said receiving antenna located in different positions relative to each other about said breast.

11. The system of claim 10, further comprising:

a microwave imaging system configured to display an interior image of said breast based upon the detected microwave energy; and

means for applying an auto-focusing technique to mitigate blurring of said image.

12. The system of claim 10, wherein said means for displaying is further configured to include

means for enhancing said image using a spectral estimation technique.

13. The system of claim 10, further comprising:

means for reducing clutter attributable to a boundary between breast tissue and adjacent tissue using a time delay estimation technique based upon, wherein said time delay estimation technique utilizes a weighted Fourier transformation and Lagrangian relaxation algorithm.