Detection of pleural effusion using transthoracic impedance
First Claim
1. A system for the detection of thoracic fluid in a subject, the system comprising:
- an implantable thoracic impedance measurement circuit, adapted to sense a thoracic impedance signal from the subject; and
a processor, coupled with the thoracic impedance measurement circuit to receive the thoracic impedance signal, and adapted to recognize a significant thoracic impedance signal, wherein the processor is adapted to detect one or both of a pleural effusion indication or a pulmonary edema indication upon recognition of the significant thoracic impedance signal and differentiate the pleural effusion indication from the pulmonary edema indication.
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Abstract
This patent document discusses systems, devices, and methods for increasing a sensitivity or specificity of thoracic fluid detection in a subject and differentiating between pleural effusion and pulmonary edema. In one example, a thoracic impedance measurement circuit senses a thoracic impedance signal. In another example, a processor receives the thoracic impedance signal and determines whether such thoracic impedance signal is “significant.” A significant thoracic impedance signal indicates the presence of thoracic fluid and may be recognized by comparing the thoracic impedance signal (or variation thereof) to a thoracic impedance threshold. When a significant thoracic impedance signal is recognized, the processor is adapted to detect one or both of: a pleural effusion indication and a pulmonary edema indication using one or a combination of: physiologic information, patient symptom information, and posture information. In another example, the thoracic impedance threshold is adjusted using such physiologic, patient symptom, or posture information.
371 Citations
32 Claims
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1. A system for the detection of thoracic fluid in a subject, the system comprising:
- an implantable thoracic impedance measurement circuit, adapted to sense a thoracic impedance signal from the subject; and
a processor, coupled with the thoracic impedance measurement circuit to receive the thoracic impedance signal, and adapted to recognize a significant thoracic impedance signal, wherein the processor is adapted to detect one or both of a pleural effusion indication or a pulmonary edema indication upon recognition of the significant thoracic impedance signal and differentiate the pleural effusion indication from the pulmonary edema indication. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16)
- an implantable thoracic impedance measurement circuit, adapted to sense a thoracic impedance signal from the subject; and
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17. A system for the detection of thoracic fluid in a subject, the system comprising:
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a thoracic impedance measurement circuit, adapted to sense a thoracic impedance signal from the subject; a processor, coupled with the thoracic impedance measurement circuit to receive the thoracic impedance signal; and a differentiation module, adapted to differentiate a pleural effusion indication and a pulmonary edema indication using, at least in part, one or a combination of;
the thoracic impedance signal, physiologic information, patient symptom information, and posture information. - View Dependent Claims (18, 19)
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20. A method for the detection of thoracic fluid in a subject, the method comprising:
- sensing a thoracic impedance signal using an implantable device from a thorax of the subject;
recognizing a significant thoracic impedance signal in the subject, including comparing the thoracic impedance signal to a thoracic impedance threshold;
detecting one or both of a pleural effusion indication upon recognizing the significant thoracic impedance signal; and
differentiating the pleural effusion indication from the pulmonary edema indication. - View Dependent Claims (21, 22, 23, 24, 25, 26, 27, 28, 29, 30)
- sensing a thoracic impedance signal using an implantable device from a thorax of the subject;
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31. A system for the detection of thoracic fluid in a subject, the system comprising:
- an implantable thoracic impedance measurement circuit, adapted to sense a thoracic impedance signal from the subject;
a processor, coupled with the thoracic impedance measurement circuit to receive the thoracic impedance signal and adapted to recognize a significant thoracic impedance signal, the processor further adapted to detect a pleural effusion indication upon recognition of the significant thoracic impedance signal; and
an external user interface coupled to the processor and adapted to receive from the processor the pleural effusion indication, the external user interface further adapted to provide a user-detectable indication of the pleural effusion indication.
- an implantable thoracic impedance measurement circuit, adapted to sense a thoracic impedance signal from the subject;
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32. A system for the detection of thoracic fluid in a subject, the system comprising:
- an implantable thoracic impedance measurement circuit, adapted to sense a thoracic impedance signal from the subject; and
a processor, coupled with the thoracic impedance measurement circuit to receive the thoracic impedance signal and adapted to recognize a significant thoracic impedance signal, the processor further adapted to detect a pleural effusion indication upon recognition of the significant thoracic impedance signal; and
an external user interface, coupled to the processor and including a user input device, the user input device adapted to collect from a user one or a combination of physiologic information, patient symptom information, and posture information, wherein the external user interface is further adapted to transmit the physiologic information, the patient symptom information, or the posture information to the processor.
- an implantable thoracic impedance measurement circuit, adapted to sense a thoracic impedance signal from the subject; and
Specification