Treating sleep apnea in patients using phrenic nerve stimulation

• US 7,340,302 B1
• Filed: 09/27/2004
• Issued: 03/04/2008
• Est. Priority Date: 09/27/2004
• Status: Expired due to Fees

• Current Assignee: Pacesetter Incorporated (Abbott Laboratories)
• Original Assignee: Pacesetter Incorporated (Abbott Laboratories)
• Inventors: Kroll, Mark W., Falkenberg, Eric
• Primary Examiner(s): MANUEL, GEORGE C
• Application Number:
  US10/951,839
• Time in Patent Office: 1,254 Days
• Field of Search: 607/2, 607 9- 18
• US Class Current: 607/9
• CPC Class Codes: A61N 1/3601 of respiratory organs
• CPC Class Codes: A61N 1/3611 Respiration control stimulating respiratory organs A61N1/3601
• CPC Class Codes: A61N 1/3627 for treating a mechanical deficiency of the heart, e.g. congestive heart failure or cardiomyopathy

Abstract

An exemplary implantable cardiac device is programmed to administer pacing therapy that treats both congestive heart failure (CHF) and sleep apnea. To treat CHF, the exemplary device delivers pacing pulses of a first voltage level via a lead in the left-sided veins of the heart. During periods of apnea, the device occasionally increases the pulse voltage and delivers one or more phrenic nerve stimulation pulses via the same lead to stimulate the phrenic nerve. This awakens the respiratory system to minimize or prevent episodes of sleep apnea. In an exemplary method, one or more phrenic nerve stimulation pulses are applied in synchronization with the pacing frequency so that the sleep apnea therapy does not disturb the normal cardiac rhythm. Other exemplary devices and methods are also disclosed.

Claims

1. An implantable cardiac device comprising:

a lead comprising at least one electrode, the lead being configured for advancement through a coronary sinus so that the electrode is positionable proximate the left ventricle;

pacing circuitry to apply pacing pulses to a patient'"'"'s heart via the electrode; and

a sleep apnea therapy module to occasionally apply one or more phrenic nerve stimulation pulses to the patient'"'"'s heart and phrenic nerve via the electrode, the phrenic nerve stimulation pulse having a voltage amplitude exceeding a pacing pulse voltage amplitude and delivered at a time when a pacing pulse is needed.

2. An implantable cardiac device as recited in claim 1, wherein the electrode is configured for placement in the great cardiac vein of the patient'"'"'s heart.

3. An implantable cardiac device as recited in claim 1, wherein at least one of the one or more phrenic nerve stimulation pulses has a pulse width of less than approximately 100 microseconds.

4. An implantable cardiac device as recited in claim 1, wherein at least one of the one or more phrenic nerve stimulation pulses has a pulse width of less than approximately 50 microseconds.

5. An implantable cardiac device as recited in claim 1, wherein the one or more phrenic nerve stimulation pulses comprises multiple short pulses with varying voltage amplitudes.

6. An implantable cardiac device as recited in claim 1, wherein the one or more phrenic nerve stimulation pulses comprises multiple short pulses with varying frequencies.

7. An implantable cardiac device as recited in claim 1, wherein the one or more phrenic nerve stimulation pulses comprises multiple short pulses with varying frequencies and with varying voltage amplitudes.

8. An implantable cardiac device as recited in claim 1, further comprising a sleep apnea detector to detect when the patient is experiencing central sleep apnea, the sleep apnea therapy module being configured to apply the one or more phrenic nerve stimulation pulses in response to when the sleep apnea detector detects central sleep apnea.

9. An implantable cardiac device comprising:

a pulse generator to generate pacing pulses and pacing pulse trains for pacing a patient'"'"'s heart; and

a therapy module to alter the pacing pulses such that the pacing pulses are effective to stimulate the patient'"'"'s heart without stimulating the patient'"'"'s phrenic nerve and the pacing pulse trains are effective to stimulate both the patient'"'"'s heart and the patient'"'"'s phrenic nerve wherein the pacing pulse trains have pulses with pulse widths of less than approximately 100 microseconds.

10. An implantable cardiac device as recited in claim 9, wherein the therapy module alters voltage amplitudes of the pacing pulses and the pacing pulse trains such that the pacing pulses have a first voltage amplitude and the pacing pulse trains have a second voltage amplitude higher than the first voltage amplitude.

11. An implantable cardiac device as recited in claim 9, wherein the pacing pulses and the pacing pulse trains are applied via a common electrode.

12. An implantable cardiac device as recited in claim 9, wherein the pacing pulse trains comprises pulses having a pulse width of approximately 50 microseconds.

13. An implantable cardiac device as recited in claim 9, wherein the pacing pulse trains comprises short pulses with varying amplitudes.

14. An implantable cardiac device as recited in claim 9, wherein the pacing pulse trains comprises short pulses with varying frequencies.

15. An implantable cardiac device comprising:

an electrode adapted for placement on a patient'"'"'s heart;

implantable means for generating pulses to be applied via the electrode to the patient'"'"'s heart; and

implantable means for altering pulse widths of the pulses to produce first pulses, which when applied via the electrode, stimulate the patient'"'"'s heart without stimulating the phrenic nerve, and to produce second pulses different from the first pulses, which when applied via the electrode, stimulate the patient'"'"'s heart and phrenic nerve.

16. An implantable cardiac device as recited in claim 15, wherein the first pulses have a larger pulse width than the second pulses.

17. An implantable and programmable cardiac device having a memory and a processor, the cardiac device being programmed to perform tasks comprising:

applying pacing pulses to pace a patient'"'"'s heart;

detecting when the patient is experiencing an episode of central sleep apnea;

determining when the patient is in an inspiration phase of a respiratory cycle; and

in response to the detecting and to the determining, selectively applying a phrenic nerve stimulation pulse to the patient'"'"'s phrenic nerve to stimulate the patient'"'"'s phrenic nerve to provoke respiration.

18. An implantable and programmable cardiac device as recited in claim 17, further programmed to apply phrenic nerve stimulation pulses every Nth pacing pulse.

19. An implantable and programmable cardiac device as recited in claim 17, wherein the phrenic nerve stimulation pulse has a higher voltage amplitude than the pacing pulses.

20. An implantable and programmable cardiac device as recited in claim 17, wherein the phrenic nerve stimulation pulse comprises a pulse train of multiple short pulses.

21. An implantable and programmable cardiac device as recited in claim 17, wherein the phrenic nerve stimulation pulse comprises a pulse train of multiple short pulses of varying amplitudes.

22. An implantable and programmable cardiac device as recited in claim 17, wherein the phrenic nerve stimulation pulse comprises a pulse train of multiple short pulses of varying frequencies.

23. A method implemented by an implantable cardiac device, comprising:

administering pacing pulses to a patient'"'"'s heart;

detecting when the patient is experiencing central sleep apnea; and

in response to detecting the central sleep apnea, selectively applying phrenic nerve stimulation pulses to the patient'"'"'s phrenic nerve, the phrenic nerve stimulation pulses having comparatively higher voltage and having comparatively shorter pulse widths than the pacing pulses.

24. A method as recited in claim 23, wherein the detecting comprises determining when a patient is in a reclined position and monitoring the patient'"'"'s activity while the patient is in the reclined position.

25. A method as recited in claim 23, wherein the detecting comprises monitoring an instantaneous signal from an activity sensor.

26. A method as recited in claim 23, wherein the selectively applying comprises applying the phrenic nerve stimulation pulses in synchronization with the pacing pulses.

27. A method as recited in claim 23, wherein the selectively applying comprises applying a phrenic nerve stimulation pulse for every Nth pacing pulse.

28. A method as recited in claim 23, wherein the phrenic nerve stimulation pulses comprise multiple short pulses.

29. A method as recited in claim 23, wherein the phrenic nerve stimulation pulses comprise multiple short pulses of varying voltage amplitudes.

30. A method as recited in claim 23, wherein the phrenic nerve stimulation pulses comprise multiple short pulses of varying voltage frequencies.

31. A method comprising:

generating pulses to be applied via an electrode to a patient'"'"'s heart; and

altering pulse widths of the pulses to produce first pulses, which when applied via the electrode, stimulate either the patient'"'"'s heart without stimulating the phrenic nerve, and to produce second pulses different from the first pulses, which when applied via the electrode, stimulate the patient'"'"'s phrenic nerve and the patient'"'"'s heart.

32. A method as recited in claim 31, wherein the first pulses have first pulse widths and first voltage amplitudes and the second pulses have second pulse widths shorter than the first pulse widths and second voltage amplitudes higher than the first voltage amplitudes.

33. A method comprising:

determining that a patient is at rest; and

while the patient is at rest,

administering a rest mode pacing therapy of comparatively lower voltage pacing pulses effective to stimulate the patient'"'"'s heart;

detecting when the patient is experiencing an episode of sleep apnea; and

in response to detecting the sleep apnea, administering sleep apnea pacing therapy of comparatively higher voltage phrenic nerve stimulation pulses that are effective to stimulate the patient'"'"'s phrenic nerve to provoke respiration.

34. A method as recited in claim 33, wherein individual phrenic nerve stimulation pulses comprises multiple short pulses.