Measurement of respiratory sinus arrhythmia using respiratory and electrogram sensors in an implantable device
First Claim
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1. A system for measuring respiratory sinus arrhythmia, to monitor a patient'"'"'s autonomic function, comprising:
- a heart beat interval sensor, for sensing the patient'"'"'s beat-to-beat heart rate and generating a heart rate signal;
a respiration sensor, for sensing the patient'"'"'s respiration and generating a respiration signal; and
a heart rate-respiration sensitivity estimating element, for estimating the sensitivity of heart rate to respiration as measurements of respiratory sinus arrhythmia, responsive to the heart rate signal from the heart beat interval sensor and the respiration signal from the respiration sensor, and using the sensitivity estimation as an indicia of autonomic responsiveness in autonomic function monitoring.
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Abstract
An apparatus for measuring a patient'"'"'s heart rate response to respiration, for monitoring the patient'"'"'s autonomic tone, includes an implantable system. The implantable system includes a sensor for generating sensed signals representing detected beat-to-beat heart rate. Further, the implantable system includes a sensor for generating sensed signals representing detected respiration. The implantable system also includes an element for estimating the sensitivity of heart rate to respiration, responsive to the sensed heart rate and respiration signals.
62 Citations
56 Claims
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1. A system for measuring respiratory sinus arrhythmia, to monitor a patient'"'"'s autonomic function, comprising:
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a heart beat interval sensor, for sensing the patient'"'"'s beat-to-beat heart rate and generating a heart rate signal; a respiration sensor, for sensing the patient'"'"'s respiration and generating a respiration signal; and a heart rate-respiration sensitivity estimating element, for estimating the sensitivity of heart rate to respiration as measurements of respiratory sinus arrhythmia, responsive to the heart rate signal from the heart beat interval sensor and the respiration signal from the respiration sensor, and using the sensitivity estimation as an indicia of autonomic responsiveness in autonomic function monitoring. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26)
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27. A system for measuring respiratory sinus arrhythmia, to monitor a patient'"'"'s autonomic function, comprising:
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a heart beat interval sensor, for sensing the patient'"'"'s beat-to-beat heart rate and generating a heart rate signal; a respiration sensor, for sensing the patient'"'"'s respiration and generating a respiration signal; and heart rate-respiration sensitivity estimating means for estimating the sensitivity of heart rate to respiration, responsive to the heart rate signal from the heart beat interval sensor and the respiration signal from the respiration sensor, and using the sensitivity estimation as an indicia of autonomic responsiveness in autonomic function monitoring.
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28. A system for measuring respiratory sinus arrhythmia, to monitor a patient'"'"'s autonomic function, comprising:
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a heart beat interval sensor, for sensing the patient'"'"'s beat-to-beat heart rate and generating a heart rate signal; a respiration sensor, for sensing the patient'"'"'s respiration and generating a respiration signal; and a heart rate-respiration measuring element, for measuring the relative amount of heart rate variability due to respiration, responsive to the heart rate signal from the heart beat interval sensor and the respiration signal from the respiration sensor, and using the measured relative amount of heart rate variability due to respiration as an indicia of autonomic responsiveness in autonomic function monitoring. - View Dependent Claims (29, 30)
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31. A method of measuring respiratory sinus arrhythmia, to monitor a patient'"'"'s autonomic function, in a system which comprises a heart beat interval sensor, for sensing the patient'"'"'s beat-to-beat heart rate and generating a heart rate signal, a respiration sensor, for sensing the patient'"'"'s respiration and generating a respiration signal, and a heart rate-respiration sensitivity estimating element, for estimating the sensitivity of heart rate to respiration as measurements of respiratory sinus arrhythmia, responsive to the heart rate signal from the heart beat interval sensor and the respiration signal from the respiration sensor, wherein the method comprises:
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heart rate sensing of the patient'"'"'s beat-to-beat heart rate and the generating of a heart rate signal, by the heart beat interval sensor; respiration sensing of the patient'"'"'s respiration and the generating of a respiration signal, by the respiration sensor; estimating the sensitivity of heart rate to respiration, responsive to the heart rate signal from the heart beat interval sensor and the respiration signal from the respiration sensor, by the heart rate-respiration sensitivity estimating element; and tracking the sensitivity estimation as an indicia of autonomic responsiveness in autonomic function monitoring. - View Dependent Claims (32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52)
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53. A method of measuring respiratory sinus arrhythmia, to monitor a patient'"'"'s autonomic function, in a system which comprises a heart beat interval sensor, for sensing the patient'"'"'s beat-to-beat heart rate and generating a heart rate signal, a respiration sensor, for sensing the patient'"'"'s respiration and generating a respiration signal, and heart rate-respiration sensitivity estimating means, for estimating the sensitivity of heart rate to respiration as measurements of respiratory sinus arrhythmia, responsive to the heart rate signal from the heart beat interval sensor and the respiration signal from the respiration sensor, wherein the method comprises:
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heart rate sensing of the patient'"'"'s beat-to-beat heart rate and the generating of a heart rate signal, by the heart beat interval sensor; respiration sensing of the patient'"'"'s respiration and the generating of a respiration signal, by the respiration sensor; and estimating the sensitivity of heart rate to respiration as measurements of respiratory sinus arrhythmia, responsive to the heart rate signal from the heart beat interval sensor and the respiration signal from the respiration sensor, and using the sensitivity estimation as an indicia of autonomic responsiveness in autonomic function monitoring, by the heart rate-respiration sensitivity estimating means.
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54. A method of measuring respiratory sinus arrhythmia, to monitor a patient'"'"'s autonomic function, in a system which comprises a heart beat interval sensor, for sensing the patient'"'"'s beat-to-beat heart rate and generating a heart rate signal, a respiration sensor, for sensing the patient'"'"'s respiration and generating a respiration signal, and a heart rate-respiration measuring element, for measuring of the relative amount of heart rate variability due to respiration, responsive to the heart rate signal from the heart beat interval sensor and the respiration signal from the respiration sensor, wherein the method comprises:
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heart rate sensing of the patient'"'"'s beat-to-beat heart rate and the generating of a heart rate signal, by the heart beat interval sensor; respiration sensing of the patient'"'"'s respiration and the generating of a respiration signal, by the respiration sensor; and measuring the relative amount of heart rate variability due to respiration, responsive to the heart rate signal from the heart beat interval sensor and the respiration signal from the respiration sensor, and using the measured relative amount of heart rate variability due to respiration as an indicia of autonomic responsiveness in autonomic function monitoring, by the heart rate-respiration comparing element. - View Dependent Claims (55, 56)
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Specification