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Methods and systems for automatically determining a neural response threshold current level

  • US 7,343,200 B2
  • Filed: 06/01/2005
  • Issued: 03/11/2008
  • Est. Priority Date: 06/01/2005
  • Status: Active Grant
First Claim
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1. A method of automatically determining a neural response threshold current level, said method comprising:

  • obtaining a plurality of neural recording signals at a plurality of different stimulation current levels;

    fitting an artifact model to each of said neural recording signals to obtain a plurality of fitted artifact model signals;

    denoising each of said neural recording signals and each of said fitted artifact model signals;

    computing a strength-of-response metric for each of said neural recording signals, said computation being based on at least one of said denoised neural recording signals and at least one of said fitted artifact model signals;

    comparing each of said strength-of-response metrics to a strength-of-response threshold to identify one or more neural response signals and one or more non-response signals contained within said neural recording signals; and

    analyzing a trend between said neural response signals and said non-response signals to determine said neural response threshold current level.

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