Gastrointestinal motility control

• US 7,343,201 B2
• Filed: 11/29/2004
• Issued: 03/11/2008
• Est. Priority Date: 11/28/2003
• Status: Expired due to Fees

• Current Assignee: UTI Limited Partnership
• Original Assignee: University Technologies International, Inc.
• Inventors: Mintchev, Martin P.
• Primary Examiner(s): SCHAETZLE, KENNEDY
• Application Number:
  US11/000,325
• Publication Number:
  US 20050137643A1
• Time in Patent Office: 1,198 Days
• Field of Search: 607/40, 607/41, 607/45, 607/61, 607/72, 607/73, 607/133
• US Class Current: 607/40
• CPC Class Codes: A61N 1/36007 of urogenital or gastrointestinal organs, e.g. for incontinence control
• CPC Class Codes: A61N 1/37229 Shape or location of the implanted or external antenna
• CPC Class Codes: A61N 1/37235 Aspects of the external programmer
• CPC Class Codes: A61N 1/3787 from an external energy source

Abstract

A method and a multichannel implantable device are described for partial or complete restoration of impaired gastrointestinal motility, or for disturbing and/or partially or completely blocking normal gastrointestinal motility using one or multiple microsystem-controlled channels of circumferentially arranged sets of two or more electrodes which provide externally-invoked synchronized electrical signals to the smooth muscles via the neural pathways.

Claims

1. A method of control of a gastrointestinal tract, or a portion thereof, the gastrointestinal tract, or portion thereof, comprising a pylorus, the method comprising the steps of:

electrically stimulating patches in the vicinity of the pylorus until the pylorus relaxes; and

applying electrical energy to the gastrointestinal tract or a portion thereof to invoke a desired motility response of the gastrointestinal tract.

2. The method of claim 1 in which the desired response is delayed emptying of the stomach.

3. The method of claim 1 in which the desired response is peristalsis.

4. The method of claim 3 in which applying electrical energy to the gastrointestinal tract comprises electrically overriding the spontaneous mechanical activity of the gastrointestinal tract or a portion thereof.

5. The method of claim 4 in which applying electrical energy to the gastrointestinal tract is caffied out asynchronously with the spontaneously existing mechanical activity of the gastrointestinal tract.

6. The method of claim 5 in which electrically oveffiding the spontaneous mechanical activity of the gastrointestinal tract or a portion thereof is caffied out using electrical signals that are varied in voltage.

7. The method of claim 6 in which electrically oveffiding the spontaneous mechanical activity of the gastrointestinal tract or a portion thereof is caffied out using electrical energy having a duty cycle less than 100%.

8. The method of claim 1 in which the desired response is externally-controlled peristalsis.

9. The method of claim 1 in which the desired response is externally-controlled delayed movement of contents through the gastrointestinal tract.

10. The method of claim 1 in which the electrical energy has a variable voltage and a duty cycle of less than 100%.

11. The method of claim 10 in which applying electrical energy to the gastrointestinal tract comprises electrically oveffiding the spontaneously existing mechanical activity in the gastrointestinal tract or in a portion thereof, in which the oveffiding is carried out asynchronously with spontaneously existing motility of the gastrointestinal tract.

12. The method of claim 11 in which:

the electrodes are implanted in a series of pairs along the gastrointestinal tract; and

the electrical pattern overriding the spontaneously existing motility of the gastrointestinal tract comprises sequential, overlapping or embedded excitation signals applied to the pairs of electrodes.

13. The method of claim 11 in which energy for the electrical oveffiding pattern is transmitted wireles sly and transcutaneously to an implanted receiver.

14. The method of claim 10 in which the duty cycle is between 10% and 90%.

15. The method of claim 10 in which the duty cycle is between 50% and 90%.

16. The method of claim 10 in which energy is transmitted to the electrodes by wirelessly transmitting energy transcutaneously to the electrodes.

17. The method of claim 10 in which the electrodes includes at least two sets of spaced apart electrodes, and the electrodes are energized to produce contractile desynchronization of muscles of the gastrointestinal tract.

18. The method of claim 17 in which the electrodes are energized randomly.

19. Apparatus for control of gastrointestinal motility, the apparatus compnsing:

an implant incorporating gastrointestinal tract electrodes; and

a controller for delivering energy to the gastrointestinal tract electrodes, the controller being configured to deliver a first electrical pattern to the electrodes to cause a muscle of the gastrointestinal tract to relax after a prolonged controlled contraction, and a second electrical pattern to the electrodes to cause a desired response of the gastrointestinal tract.

20. The apparatus of claim 19 in which the controller is configured to deliver the second electrical pattern as a pattern that oveffides the spontaneously existing mechanical activity of the gastrointestinal tract.