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Brain stimulation models, systems, devices, and methods

  • US 7,346,382 B2
  • Filed: 07/07/2004
  • Issued: 03/18/2008
  • Est. Priority Date: 07/07/2004
  • Status: Active Grant
First Claim
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1. A computer-assisted method comprising:

  • a) obtaining volumetric imaging data representing an anatomic volume of a brain of a patient;

    b) generating from the volumetric imaging data a computer model that allows a non-uniform conductivity to represent inhomogeneous and anisotropic tissue properties;

    c) using the computer model to calculate at least one volume of influence, wherein the volume of influence comprises a predicted volume of tissue affected by an electrical stimulation delivered by an electrode at a corresponding at least one candidate electrode target location, and wherein calculating the volume of influence comprises at least one of;

    i) calculating a second difference of a potential distribution to represent the volume of influence;

    orii) calculating the volume of influence includes using an electric field model together with a multi-compartment neuron model oriented and positioned to represent at least one actual nerve pathway in the anatomic volume; and

    d) selecting a recommended electrode target location in the anatomic volume using the at least one calculated volume of influence.

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