Polarized in vivo imaging device, system and method

• US 7,347,817 B2
• Filed: 07/05/2005
• Issued: 03/25/2008
• Est. Priority Date: 08/02/2001
• Status: Expired due to Fees

• Current Assignee: Given Imaging Limited (Medtronic Plc)
• Original Assignee: Given Imaging Limited (Medtronic Plc)
• Inventors: Pascal, Amit, Glukhovsky, Arkady
• Primary Examiner(s): Leubecker; John P.
• Application Number:
  US11/173,153
• Publication Number:
  US 20060036131A1
• Time in Patent Office: 994 Days
• Field of Search: 600/181, 600/160, 600/179, 600/473, 600/476
• US Class Current: 600/181
• CPC Class Codes: A61B 1/00186 with imaging filters
• CPC Class Codes: A61B 1/041 Capsule endoscopes for imaging
• CPC Class Codes: A61B 1/0605 for spatially modulated illumination
• CPC Class Codes: A61B 1/0638 providing two or more wavelengths
• CPC Class Codes: A61B 1/0646 with illumination filters
• CPC Class Codes: A61B 1/0655 Control therefor
• CPC Class Codes: A61B 1/0684 using light emitting diodes [LED]

Abstract

An autonomous in vivo sensing device may include a polarizing filter to polarize light emitted by an illumination unit, and to block light specularly reflected from a turbid media from reaching an imager of such device. An autonomous in vivo sensing device with monochromatic illumination units to alternatingly illuminate a target area with light of different wavelengths, and to subtract an image illuminated by light in a first wavelength from an image illuminated by light in a second wavelength, to produce an image of a sub-surface layer of such target area.

Claims

1. An autonomous in vivo device comprising:

an illumination unit;

a polarizer to polarize light from said illumination unit;

an imager;

a filter to block said polarized light from reaching said imager of said autonomous in vivo device; and

a controller to coordinate an illumination by said illumination unit with an activation of said polarizer.

2. The device as in claim 1, comprising an optical dome over said illumination unit, said optical dome comprising said polarizer.

3. The device as in claim 2, wherein said polarizer comprised in said optical dome is configured orthogonally to a plurality of light beams emitted by said illumination unit.

4. The device as in claim 2, wherein said polarizer is a curved polarizer.

5. The device as in claim 1, wherein said filter is to block said polarized light that is specularly reflected from a turbid media.

6. The device as in claim 1, wherein said filter is to allow light in a polarization opposite to said polarized light to reach said imager.

7. The device as in claim 6, wherein said light in a polarization opposite to said polarized light comprises light that was diffused in an endo-luminal tissue.

8. The device as in claim 1, comprising a plurality of illumination units surrounding said imager.

9. The device as in claim 1, wherein said polarizer includes a liquid crystal.

10. The device as in claim 1, wherein said controller is to coordinate an illumination by said illumination unit with an activation of said imager.

11. The device as in claim 1, comprising a plurality of monochromatic illumination units, a first of said plurality of monochromatic illumination units to emit light having a wavelength of between 300 nm and 450 nm, a second of said monochromatic illumination units to emit light having a wavelength of between 450 nm and 700 nm, and a third of said plurality of monochromatic light units to emit light having a wavelength of between 700 nm and 1100 nm.

12. The device as in claim 1, comprising a plurality of monochromatic illumination units.

13. The device as in claim 12, wherein said controller is configured to activate a first monochromatic illumination unit independently of a second monochromatic illumination unit.

14. The device as in claim 12, wherein said controller is to coordinate:

an activation of a monochromatic illumination unit of said plurality of monochromatic illumination units to emit a monochromatic light beam; and

an activation of said polarizer, said activation of said polarizer to;

polarize, in a first polarization state, a light beam emitted from said monochromatic illumination unit; and

polarize, in a second polarization state, a light beam emitted from said monochromatic illumination unit.

15. The device as in claim 14, comprising a memory to store image data collected by said imager, said image data comprising:

image data of a target area illuminated by a light beam polarized in a first polarization state; and

image data of said target area illuminated by a light beam polarized in said second polarization state.

16. The device as in claim 1, comprising a transmitter to transmit image data to an external data receiver.

17. The device as in claim 1, wherein said polarizer is to polarize said light in a first polarization state, and to polarize said light in a second polarization state.

18. The device as in claim 1, comprising an immobilizer to immobilize said device adjacent to an endoluminal target area.

19. A system comprising:

an autonomous in vivo sensing device comprising;

a plurality of monochromatic illumination units;

a polarizer to polarize light from said illumination units;

an imager; and

a controller to coordinate an illumination by at least one of said plurality of monochromatic illumination units with an activation of said polarizer.

20. The system as in claim 19, comprising a processor, said processor to subtract:

image data of a target area, said target area illuminated by a first monochromatic illumination unit, from

image data of said target area, said target area illuminated by a second monochromatic illumination unit.

21. The system as in claim 19, wherein a first of said plurality of monochromatic illumination units is to emit a light beam having a wavelength of between 300 nm and 450 nm, a second of said monochromatic illumination units is to emit a light beam having a wavelength of between 450 nm and 700 nm, and a third of said monochromatic illumination units is to emit a light beam having a wavelength of between 700 nm and 1100.

22. The system as in claim 19, comprising a filter to block polarized light from reaching said imager.

23. A method comprising:

illuminating a target area with light from an illumination unit of an autonomous in vivo sensing device;

obtaining an image of said illuminated target;

polarizing said light;

blocking with a filter said polarized light from reaching an imager; and

obtaining a polarized image of said illuminated target.

24. The method as in claim 23, wherein blocking said polarized light from reaching said imager, comprises blocking said polarized light that was specularly reflected from a turbid media.

25. The method as in claim 23, wherein said illuminating a target area comprises illuminating said target area with light from a plurality of monochromatic illumination units.

26. The method as in claim 25, comprising:

illuminating said target area with said plurality of monochromatic light beams;

activating one of said monochromatic illumination units;

activating another of said monochromatic illumination units and subtracting;

image data of said target area illuminated by said one of said monochromatic illumination units, from

image data of said target area illuminated by said another of said monochromatic illumination units.

27. The method as in claim 23, wherein said illuminating said target area comprises illuminating said target area with a plurality of monochromatic light beams wherein:

a first light beam is at a wavelength of between 300 nm and 450 nm;

a second light beam is at a wavelength of between 450 nm and 700 nm; and

a third light beam is at a wavelength of between 700 nm and 1100 nm.

28. The method as in claim 23, wherein said polarizing said light comprises:

polarizing to a first polarization state a first of a plurality of light beams; and

polarizing to a second polarization state a second of said plurality of light beams.