Immunostimulating coating for surgical devices

• US 7,348,021 B2
• Filed: 01/17/2003
• Issued: 03/25/2008
• Est. Priority Date: 09/27/1999
• Status: Expired due to Fees

• Current Assignee: Stellen Medical LLC
• Original Assignee: Brennen Medical LLC (Mölnlycke Holding AB)
• Inventors: Klein, Barbara K.
• Primary Examiner(s): KENNEDY, SHARON E
• Application Number:
  US10/347,023
• Publication Number:
  US 20030157143A1
• Time in Patent Office: 1,894 Days
• Field of Search: 424/423, 424/443, 442/123, 514/54, 604/500
• US Class Current: 424/423
• CPC Class Codes: A61L 27/20 Polysaccharides
• CPC Class Codes: A61L 31/042 Polysaccharides
• CPC Class Codes: Y10T 442/2525 Coating or impregnation functions biologically [e.g., insect repellent, antiseptic, insecticide, bactericide, etc.]

Abstract

The present invention discloses an immunostimulating agent that may be applied to various surgical devices to promote rapid healing and the ready acceptance and integration of the surgical devices with the body tissues at the surgical site.

Claims

1. A surgical mesh structure providing post-operative reinforcement for organic tissue adjacent to the surgical mesh structure proximate a surgical implantation site, the surgical mesh structure comprising:

a surgical mesh adapted to be implanted adjacent to the organic tissue proximate the surgical implantation site;

wherein the surgical mesh when implanted has a coating of beta-D-glucan and the coating of beta-D-glucan promotes rapid incorporation and acceptance of the surgical mesh into the organic tissue in vivo, such that the surgical mesh becomes a part of a matrix for tissue ingrowth, thus providing the post-operative reinforcement for the organic tissue.

2. A method of forming post-operative, reinforced organic tissue at a surgical site, the surgical site including organic tissue, the method comprising the steps of:

providing a surgical mesh having a coating of beta-D-glucan;

implanting the surgical mesh adjacent to the organic tissue; and

allowing the organic tissue to grow into the surgical mesh in vivo;

whereby the coating of beta-D-glucan promotes rapid incorporation and acceptance of the surgical mesh into the organic tissue, thus reinforcing the organic tissue.

3. A method of forming post-operative reinforced organic tissue at a surgical site, the surgical site including organic tissue, the method comprising the steps of:

providing a surgical mesh having a coating of beta-D-glucan; and

implanting the surgical mesh adjacent to the organic tissue;

wherein the coating of beta-D-glucan promotes rapid incorporation and acceptance of the surgical mesh into the organic tissue post-operatively to form the reinforced organic tissue in vivo.

4. A method of forming post-operative reinforced organic tissue at a surgical site, the surgical site including organic tissue, the method comprising the steps of:

providing a surgical mesh having a coating of beta-D-glucan;

implanting the surgical mesh adjacent to the organic tissue; and

allowing the organic tissue to grow into the surgical mesh, thus providing the reinforced organic tissue in vivo.