Directed microwave chemistry
First Claim
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1. A method for accelerating a biospecific interaction of a reactant in an aqueous or organic solution proximal to a surface, said method comprising:
- (a) contacting a composite with said reactant, said composite comprising;
(i) a solid material susceptible to microwave heating attached to (ii) a surface molecule,(b) applying an electromagnetic field of a wavelength of between 1 cm and 100 m to said composite resulting in direct microwave heating of said solid material, without substantially heating said aqueous or organic solution so that the temperature of the solid material is higher than that of the surface molecule, and(c) allowing said composite to react with said reactant, wherein the reactant is thermally proximal to the composite, whereby the reactant is heated by heat transfer from the heated solid material and binds to the surface molecule at a greater rate than without heating from the heated soild material, thereby accelerating said biospecific interaction.
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Abstract
The present invention concerns a novel means by which chemical preparations can be made. Reactions can be accelerated on special chips using microwave energy. The chips contain materials that efficiently absorb microwave energy causing chemical reaction rate increases. The invention is important in many small scale chemical transformations including those used in protein chemistry and in combinatorial chemistry.
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Citations
15 Claims
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1. A method for accelerating a biospecific interaction of a reactant in an aqueous or organic solution proximal to a surface, said method comprising:
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(a) contacting a composite with said reactant, said composite comprising;
(i) a solid material susceptible to microwave heating attached to (ii) a surface molecule,(b) applying an electromagnetic field of a wavelength of between 1 cm and 100 m to said composite resulting in direct microwave heating of said solid material, without substantially heating said aqueous or organic solution so that the temperature of the solid material is higher than that of the surface molecule, and (c) allowing said composite to react with said reactant, wherein the reactant is thermally proximal to the composite, whereby the reactant is heated by heat transfer from the heated solid material and binds to the surface molecule at a greater rate than without heating from the heated soild material, thereby accelerating said biospecific interaction. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
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14. A method for a biospecific interaction of a biologically active reactant in an aqueous or organic solution proximal to a surface, said method comprising:
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(a) contacting a composite with said reactant, said composite comprising;
(i) a solid material susceptible to microwave heating attached to (ii) a surface molecule,(b) applying an electromagnetic field of a wavelength of between 1 cm and 100 m to said composite resulting in direct microwave heating of said solid material without substantially heating said aqueous or organic solution so that the temperature of the solid material is higher than that of the surface molecule, and (c) allowing said composite to react with said reactant, wherein the reactant is thermally proximal to the composite so that the heated solid material heats the thermally proximal reactant, whereby the reactant maintains biological activity and binds to the surface molecule at a greater rate than without heating from the heated solid material, thereby accelerating said biospecific interaction while maintaining the biological activity of the reactant. - View Dependent Claims (15)
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Specification