Solid-phase peptide synthesis and agent for use in such synthesis

• US 7,348,404 B2
• Filed: 06/19/2006
• Issued: 03/25/2008
• Est. Priority Date: 09/09/1996
• Status: Expired due to Fees

• Current Assignee: Zealand Pharma A/S
• Original Assignee: Zealand Pharma A/S
• Inventors: Holm, Arne, Larsen, Bjarne Due
• Primary Examiner(s): Tsang; Cecilia J.
• Assistant Examiner(s): AUDET, MAURY A
• Application Number:
  US11/455,388
• Publication Number:
  US 20070004905A1
• Time in Patent Office: 645 Days
• Field of Search: 530/334
• US Class Current: 530/334
• CPC Class Codes: C07K 1/04 on carriers C07K1/003, C07K1/006 take precedence
• CPC Class Codes: C07K 1/042 characterised by the nature of the carrier
• CPC Class Codes: Y02P 20/55 Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Abstract

The present invention relates to an improved process for the production of peptides by solid-phase synthesis. The invention also relates to agents which are useful in solid-phase peptide synthesis.

Claims

1. A method of synthesizing a modified peptide having the following structure:

2. The method of claim 1, wherein said pre-sequence peptide consists of from 5 to 7 amino acid residues.

3. The method of claim 1, wherein said pre-sequence peptide consists of a polylysine.

4. The method of claim 3, wherein said pre-sequence peptide consists of -(Lys)₆-.

5. The method of claim 1, wherein the yield or purity of said modified peptide is increased in comparison to the synthesis of the target peptide prepared under the same conditions without said pre-sequence peptide.