Device and process for extracorporeal treatment by citrate anticoagulant

• US 7,351,218 B2
• Filed: 12/19/2003
• Issued: 04/01/2008
• Est. Priority Date: 12/20/2002
• Status: Active Grant

• Current Assignee: Gambro Lundia AB (Baxter International Inc.)
• Original Assignee: Gambro Lundia AB (Baxter International Inc.)
• Inventors: Bene, Bernard
• Primary Examiner(s): Zalukaeva; Tatyana
• Assistant Examiner(s): Craig; Paula L.
• Application Number:
  US10/739,273
• Publication Number:
  US 20040133145A1
• Time in Patent Office: 1,565 Days
• Field of Search: 604/6.07, 604/5.01, 604/5.04, 604/6.06, 210/739, 422/47
• US Class Current: 604/6.07
• CPC Class Codes: A61M 1/342 Adding solutions to the blood, e.g. substitution solutions for preventing coagulation A61M1/3672
• CPC Class Codes: A61M 1/3434 with pre-dilution and post-dilution
• CPC Class Codes: A61M 1/3437 downstream of the filter, e.g. post-dilution with filtrate
• CPC Class Codes: A61M 1/3458 having electrolytes not present in the dialysate
• CPC Class Codes: A61M 1/3626 Gas bubble detectors
• CPC Class Codes: A61M 1/3672 Means preventing coagulation
• CPC Class Codes: A61M 1/3675 Deactivation

Abstract

A device for treating blood by extracorporeal circulation comprising a filter having a first chamber and a second chamber separated by a semi-permeable membrane. The device has an arterial line connected to the first chamber of the filter, a venous line issuing from the first chamber of the filter, a channel used for pre-infusion of a substance for regional anticoagulation and linked to the arterial line, a purge channel issuing from the second chamber of the filter, and an air separator on the venous line. The device also includes a line for post-infusion of a solution at least partially re-establishing the ionic equilibrium of the blood downstream of the air separator, the post-infusion line being configured immediately upstream of an air detector.

Claims

1. A device for treating blood by extracorporeal circulation comprising:

a filter having a first chamber and a second chamber separated by a semi-permeable membrane;

an arterial line connected to the first chamber of the filter;

a venous line issuing from the first chamber of the filter, the venous line having a tube portion;

a channel used for pre-infusion of a substance for local anticoagulation and linked to the arterial line;

a purge channel issuing from the second chamber of the filter;

an air separator on the venous line, said air separator being the only air separator present in the venous line and does not contain an air detector;

a line for post-infusion of a solution at least partially re-establishing the ionic equilibrium of the blood downstream of the air separator;

an air detector; and

a reservoir connected to the post-infusion line and containing the solution at least partially re-establishing the ionic equilibrium of the blood, wherein, the post infusion line is mounted immediately upstream of the air detector, the tube portion of the venous line extending between the air detector and a patient venous line connector configured on said venous line, said tube portion being configured not to receive another line or another injection device.

2. A device for treating blood by extracorporeal circulation according to claim 1, wherein the venous line comprises a channel configured to receive an occlusion means downstream of the air detector.

3. A device for treating blood by extracorporeal circulation according to claim 2, wherein the occlusion means is a clamp.

4. A device for treating blood by extracorporeal circulation according to claim 1, wherein the air separator comprises a bubble trap.

5. A device for treating blood by extracorporeal circulation according to claim 1, wherein the solution for regional anticoagulation contains citrate ions.

6. A device for treating blood by extracorporeal circulation according to claim 5, wherein the solution for regional anticoagulation contains a solution of trisodium citrate dihydrate.

7. A device for treating blood by extracorporeal circulation according to claim 5, wherein the solution for regional anticoagulation contains a solution of Anticoagulant Citrate Dextrose (ACD) comprising trisodium citrate dihydrate and citric acid monohydrate.

8. A device for treating blood by extracorporeal circulation according to claim 1, wherein the solution at least partially re-establishing the ionic equilibrium of the blood contains calcium ions.

9. A device for treating blood by extracorporeal circulation according to claim 8, wherein the solution at least partially re-establishing the ionic equilibrium of the blood contains an isotonic solution comprising calcium chloride, potassium chloride, and magnesium chloride.

10. A device for treating blood by extracorporeal circulation according to claim 1, wherein the channel used for pre-infusion is connected immediately downstream of a patient arterial line connector.

11. A device for treating blood by extracorporeal circulation according to claim 1 comprising means for regulating the blood flow rate, the channel used for pre-infusion being connected to the arterial line upstream said regulating means.

12. A device for treating blood by extracorporeal circulation according claim 11, wherein said regulating means comprises first means for regulating the blood flow rate associated with the arterial line.

13. A device for treating blood by extracorporeal circulation according to claim 12, wherein said regulating means comprises second means for regulating the flow rate of liquid operationally associated with the channel used for pre-infusion.

14. A device for treating blood by extracorporeal circulation according to claim 13, wherein said regulating means comprises third means for regulating the flow rate of liquid operationally associated with the post-infusion line.

15. A device for treating blood by extracorporeal circulation according to claim 14, wherein said regulating means comprises fourth means for regulating the flow rate of liquid operationally associated with the purge channel issuing from the second chamber of the filter.

16. A device for treating blood by extracorporeal circulation according to claim 15, comprising a second means for measuring the flowrate of liquid operating on the intake line and fifth means for regulating the flowrate of liquid operating on the intake line.

17. A device for treating blood by extracorporeal circulation according to claim 16, wherein the calculation and control unit receives the signals emitted by one or more means for measuring the flowrate of liquid and controls one or more means for regulating the flowrate of liquid in order to initiate a hemofiltration or hemodiafiltration operating mode.

18. A device for treating blood by extracorporeal circulation according to claim 11 comprising first means for measuring the flow rate of liquid operating on the purge channel and comprising a calculation and control unit for receiving the signals emitted by said measuring means and for controlling one or more means for regulating the flow rate.

19. A device for treating blood by extracorporeal circulation according to claim 11, comprising an intake line to the second chamber of the filter connecting up with a source of dialysis liquid.

20. A device for treating blood by extracorporeal circulation according to claim 19, wherein the dialysis liquid does not comprise calcium ions.

21. A device for treating blood by extracorporeal circulation according to one of claims 18, 19, 20 or 16 wherein the means of measuring the flowrate of liquid comprises a flow meter.

22. A device for treating blood by extracorporeal circulation according to claim 11, wherein each means of regulating the flowrate of liquid comprises a pump or a valve.

23. A device for treating blood by extracorporeal circulation according to claim 1, comprising a first balance for weighing a first reservoir connected to the channel used for pre-infusion and containing the substance for local anticoagulation.

24. A device for treating blood by extracorporeal circulation according to claim 23, comprising a second balance for weighing a second reservoir connected to the post-infusion line and containing the solution at least partially re-establishing the ionic equilibrium of the blood.

25. A device for treating blood by extracorporeal circulation according to claim 1, comprising:

means for regulating the blood flow rate, the channel used for pre-infusion being connected to the arterial line upstream said regulating means;

a first balance for weighing a first reservoir connected to the channel used for pre-infusion and containing the substance for local anticoagulation;

a second balance for weighing a second reservoir connected to the post-infusion line and containing the solution at least partially re-establishing the ionic equilibrium of the blood; and

a calculation and control unit for receiving the signals emitted by at least one of the two balances and for controlling one or more means of regulating the flowrate of liquid.