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Musculo-skeletal implant having a bioactive gradient

  • US 7,351,423 B2
  • Filed: 07/26/2005
  • Issued: 04/01/2008
  • Est. Priority Date: 09/01/2004
  • Status: Active Grant
First Claim
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1. An implant for repair of a musculoskeletal defect comprising:

  • a) a foam matrix having a central region, an upper region, a lower region and a peripheral region, andb) a first bioactive agent present within a first of the regions of the foam matrix,c) a second bioactive agent present within a second of the regions of the foam matrix,wherein the presence of the bioactive agents in different regions of the foam matrix is characterized by different controlled, gradual spatial concentration gradients.

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