Musculo-skeletal implant having a bioactive gradient
First Claim
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1. An implant for repair of a musculoskeletal defect comprising:
- a) a foam matrix having a central region, an upper region, a lower region and a peripheral region, andb) a first bioactive agent present within a first of the regions of the foam matrix,c) a second bioactive agent present within a second of the regions of the foam matrix,wherein the presence of the bioactive agents in different regions of the foam matrix is characterized by different controlled, gradual spatial concentration gradients.
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Abstract
This invention relates to an implant for a musculoskeletal defect having a bioactive agent having a concentration gradient.
44 Citations
24 Claims
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1. An implant for repair of a musculoskeletal defect comprising:
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a) a foam matrix having a central region, an upper region, a lower region and a peripheral region, and b) a first bioactive agent present within a first of the regions of the foam matrix, c) a second bioactive agent present within a second of the regions of the foam matrix, wherein the presence of the bioactive agents in different regions of the foam matrix is characterized by different controlled, gradual spatial concentration gradients. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24)
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Specification