Systems and methods for enhancing or optimizing neural stimulation therapy for treating symptoms of movement disorders and/or other neurologic dysfunction
First Claim
Patent Images
1. A method comprising:
- applying at least one set of test neural stimulation signals to a patient having a neurologic dysfunction;
acquiring at least one from the group of a set of coherence measurements and a set of silent period measurements; and
determining a set of therapeutic neural stimulation parameters directed toward affecting the patient'"'"'s neurologic dysfunction;
delivering cortical stimulation to the patient; and
performing an adjunctive therapy in conjunction with delivering cortical stimulation.
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Abstract
In one embodiment, a procedure directed toward enhancing neural stimulation therapy efficacy comprises acquiring coherence and/or silent period measurements to facilitate and/or effectuate determination of neural stimulation parameters corresponding to a treatment program, and/or modification of neural stimulation parameters associated with a treatment program in view of short-term changes in a patient'"'"'s symptomatic state and/or persistent or lasting changes in a patient'"'"'s neurofunctional condition.
403 Citations
45 Claims
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1. A method comprising:
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applying at least one set of test neural stimulation signals to a patient having a neurologic dysfunction; acquiring at least one from the group of a set of coherence measurements and a set of silent period measurements; and determining a set of therapeutic neural stimulation parameters directed toward affecting the patient'"'"'s neurologic dysfunction; delivering cortical stimulation to the patient; and performing an adjunctive therapy in conjunction with delivering cortical stimulation. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8)
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9. A method comprising:
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establishing a reference treatment state in a patient, the reference treatment state directed toward producing a reference symptomatic state, the reference treatment state established at least partly through delivery of neural stimulation to the patient in accordance with a first set of neural stimulation parameters; acquiring reference patient state information corresponding to the reference treatment state, the reference patient state information comprising at least one from the group of a set of coherence measurements and a set of silent period measurements; establishing a shifted symptomatic state in the patient; acquiring shifted patient state information corresponding to the shifted symptomatic state, the shifted patient state information comprising at least one from the group of a set of coherence measurements and a set of silent period measurements; evaluating the shifted patient state information relative to the reference patient state information; and determining a second set of neural stimulation parameters directed toward accommodating the shifted symptomatic state. - View Dependent Claims (10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22)
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23. A method comprising:
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treating a patient having a neurofunctional deficit in accordance with a treatment program comprising a neural stimulation procedure that corresponds to a first set of neural stimulation parameters; acquiring at least one from the group of a reference set of coherence measurements and a reference set of silent period measurements; interrupting a neural stimulation procedure; acquiring at least one from the group of a comparison set of coherence measurements and a comparison set of silent period measurements; and determining whether evidence of a persistent change corresponding to the patient'"'"'s neurofunctional deficit exists in the absence of neural stimulation. - View Dependent Claims (24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37)
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38. A method comprising:
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treating a patient having a neurofunctional deficit in accordance with a treatment program comprising a cortical stimulation procedure corresponding to a first set of neural stimulation parameters; interrupting cortical stimulation; determining whether evidence of a persistent change corresponding to the patient'"'"'s neurofunctional deficit exists in the absence of cortical stimulation; and determining a second set of neural stimulation parameters that facilitate accommodation of a persistent change in the patient'"'"'s neurofunctional deficit. - View Dependent Claims (39, 40, 41, 42, 43, 44, 45)
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Specification