Method and pharmaceutical composition for treating inflammation

• US 7,354,575 B2
• Filed: 03/28/2005
• Issued: 04/08/2008
• Est. Priority Date: 09/17/2001
• Status: Expired due to Fees

• Current Assignee: Yeda Research and Development Co. Ltd. (Weizmann Institute of Science)
• Original Assignee: Yeda Research and Development Co. Ltd. (Weizmann Institute of Science)
• Inventors: Flaishon, Liat, Shachar, Idit
• Primary Examiner(s): Kemmerer; Elizabeth C.
• Assistant Examiner(s): BORGEEST, CHRISTINA M
• Application Number:
  US11/090,188
• Publication Number:
  US 20050169887A1
• Time in Patent Office: 1,107 Days
• Field of Search: None
• US Class Current: 424/85.5
• CPC Class Codes: A61K 38/217 IFN-gamma
• CPC Class Codes: A61P 29/00 Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
• CPC Class Codes: Y02A 50/30 Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

A method of treating an inflammation in a subject in need thereof is disclosed. The method comprises locally or systemically administering to the subject IFN-gamma in an amount so as to achieve an IFN-gamma bulk tissue concentration at a site of inflammation of 1-8,000 units per kilogram body weight, thereby ameliorating the inflammation.

Claims

1. A method of treating an intestinal inflammation in a human subject in need thereof, the method comprising systemically administering to the human subject interferon-gamma comprising 0.32 to 19.2 units per kilogram of body weight, thereby treating the intestinal inflammation in the human subject.

2. The method of claim 1, wherein the intestinal inflammation comprises Crohn'"'"'s disease.

3. The method of claim 1, wherein said interferon-gamma comprising 0.32 to 19.2 units per kilogram of body weight is equivalent to a murine dose of 4 to 240 units per kilogram of body weight.

4. A method of treating rheumatoid arthritis in a human subject, the method comprising systemically administering to the human subject in need thereof a dose of interferon-gamma comprising 0.04 to 80 units per kilogram of body weight, thereby treating the rheumatoid arthritis in the human subject.

5. The method of claim 4, wherein said interferon-gamma comprising 0.04 to 80 units per kilogram of body weight is equivalent to a murine dose of 0.5 to 1000 units per kilogram of body weight.

6. A method of reducing asthma symptoms in a human subject, the method comprising systemically administering to the human subject in need thereof a dose of interferon-gamma comprising 0.32 to 19.2 units per kilogram of body weight.

7. The method of claim 6, wherein said interferon-gamma comprising 0.32 to 19.2 units per kilogram of body weight is equivalent to a murine dose of 4 to 240 units per kilogram of body weight.