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Genetically modified tumor-targeted bacteria with reduced virulence

  • US 7,354,592 B2
  • Filed: 02/23/2005
  • Issued: 04/08/2008
  • Est. Priority Date: 09/10/1997
  • Status: Expired due to Fees
First Claim
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1. A method of inhibiting the growth or reducing the volume of a solid tumor cancer, comprising administering an effective amount of a mutant Salmonella sp. to a patient having a solid tumor cancer, wherein said mutant Salmonella sp. comprises a disrupted msbB gene and is capable of targeting a solid tumor cancer when administered in vivo.

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