Bacillus anthracis protective antigen
First Claim
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1. An isolated polynucleotide comprising the nucleic acid sequence of SEQ ID NO:
- 1, wherein said polynucleotide encodes a recombinant Bacillus anthracis Protective Antigen (rPA).
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Abstract
A polynucleotide sequence is provided, comprising: a nucleic acid sequence having at least 75% identity to SEQ ID NO: 1, wherein said nucleic acid sequence encodes recombinant Bacillus anthracis Protective Antigen (rPA); or a fragment of said nucleic acid sequence wherein said fragment encodes a fragment of recombinant Bacillus anthracis Protective Antigen (rPA).
Also provided are expression vectors and host cells comprising the polynucleotide sequence of the invention, and methods for producing rPA or a fragment thereof.
The invention further provides antigenic compositions and corresponding methods and uses for inducing an immune response.
15 Citations
23 Claims
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1. An isolated polynucleotide comprising the nucleic acid sequence of SEQ ID NO:
- 1, wherein said polynucleotide encodes a recombinant Bacillus anthracis Protective Antigen (rPA).
- View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20)
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21. A vector comprising the nucleic acid sequence of SEQ ID NO:
- 4.
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22. The vector deposited with the ECACC under the accession number 04061401.
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23. The vector deposited with the ECACC under the accession number 04052501.
Specification