Treatment of CNS disorders using CNS target modulators

• US 7,355,042 B2
• Filed: 04/23/2004
• Issued: 04/08/2008
• Est. Priority Date: 10/16/2001
• Status: Expired due to Fees

• Current Assignee: Hypnion, Inc. (Eli Lilly and Company)
• Original Assignee: Hypnion, Inc. (Eli Lilly and Company)
• Inventors: Leighton, Harry Jefferson, White, James F., Hangauer, David G., Solomon, Michael, Edgar, Dale M., Mignot, Emmanuel J. M., Shiosaki, Kazumi
• Primary Examiner(s): COLEMAN, BRENDA LIBBY
• Application Number:
  US10/831,553
• Publication Number:
  US 20050080265A1
• Time in Patent Office: 1,446 Days
• Field of Search: 540/542, 540/548, 540/551
• US Class Current: 540/542
• CPC Class Codes: A61K 47/64 Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent peptidic linkers A61K47/65
• CPC Class Codes: A61P 25/00 Drugs for disorders of the nervous system
• CPC Class Codes: A61P 25/20 Hypnotics; Sedatives
• CPC Class Codes: A61P 43/00 Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
• CPC Class Codes: C07D 211/14 with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
• CPC Class Codes: C07D 211/46 having a hydrogen atom as the second substituent in position 4
• CPC Class Codes: C07D 211/70 with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
• CPC Class Codes: C07D 213/38 having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom
• CPC Class Codes: C07D 213/55 Acids; Esters
• CPC Class Codes: C07D 243/38 [b, e]- or [b, f]-condensed with six-membered rings
• CPC Class Codes: C07D 273/06 Seven-membered rings
• CPC Class Codes: C07D 281/16 [b, f]-condensed
• CPC Class Codes: C07D 313/12 [b,e]-condensed
• CPC Class Codes: C07D 401/06 linked by a carbon chain containing only aliphatic carbon atoms
• CPC Class Codes: C07D 405/04 directly linked by a ring-member-to-ring-member bond
• CPC Class Codes: C07D 405/14 containing three or more hetero rings
• CPC Class Codes: C07D 417/04 directly linked by a ring-member-to-ring-member bond

Abstract

The invention is directed to compositions and methods useful for treating Central Nervous System (CNS) disorders. Furthermore, the invention provides compositions and methods of treating sleep disorders. More specifically, the invention is directed to the compositions and use of derivatized, histamine antagonists for the treatment of sleep disorders.

Claims

1. A compound having the formula