Devices, systems and methods for acute or chronic delivery of substances or apparatus to extravascular treatment sites
First Claim
1. A system for delivering substances or apparatus to an extravascular target site within the body of a human or veterinary patient, said system comprising:
- a. a vessel wall penetrating catheter that comprises i) a flexible catheter body that is insertable into the vasculature of the patient and ii) a vessel wall penetrating member that is advanceable laterally from the catheter body, said vessel wall penetrating member having a lumen extending longitudinally therethrough, said penetrating member being sufficiently long to advance through the full thickness of the wall of a blood vessel in which the catheter body is positioned to an extravascular target site located beyond that blood vessel wall; and
,b. a delivery catheter having a lumen extending longitudinally therethrough, said delivery catheter being advanceable through the lumen of the vessel wall penetrating member to said extravascular target site;
said vessel wall penetrating member being retractable into the catheter body of the vessel wall penetrating catheter and the vessel wall penetrating catheter being removable from the patient'"'"'s body such that the delivery catheter remains indwelling with the distal end of the delivery catheter located at the extravascular target site.
2 Assignments
0 Petitions
Accused Products
Abstract
Methods and apparatus for delivery of substances or apparatus to target sites located outside blood vessels within the body of a human or animal patient. A vessel wall penetrating catheter is inserted into the vasculature, positioned and oriented within a blood vessel near the target extravascular site and a penetrator is advanced from the catheter so as to penetrate outwardly through the wall of the blood vessel in the direction of the target site. Thereafter, a delivery catheter is passed through a lumen of the penetrator to the target site. A desired substance or apparatus is then delivered to or obtained from the target site. In some applications, the penetrator may be retracted into the vessel wall penetrating catheter and the vessel wall penetrating catheter may be removed, leaving the delivery catheter in place for chronic or continuous delivery of substance(s) to and/or obtaining of information or samples from the target site. Alternatively, a delivery catheter having an occlusion member or balloon may be advanced into a vein or venule and the occlusion member or balloon may be used to occlude the lumen of the vein or venule during and after injection of a substance through the catheter, such that the substance will not be carried away by normal venous blood flow and will remain in the vein or venule for a sufficient period of time to have its intended effect (e.g. to enter adjacent tissues through capillary beds drained by that vein or venule).
168 Citations
128 Claims
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1. A system for delivering substances or apparatus to an extravascular target site within the body of a human or veterinary patient, said system comprising:
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a. a vessel wall penetrating catheter that comprises i) a flexible catheter body that is insertable into the vasculature of the patient and ii) a vessel wall penetrating member that is advanceable laterally from the catheter body, said vessel wall penetrating member having a lumen extending longitudinally therethrough, said penetrating member being sufficiently long to advance through the full thickness of the wall of a blood vessel in which the catheter body is positioned to an extravascular target site located beyond that blood vessel wall; and
,b. a delivery catheter having a lumen extending longitudinally therethrough, said delivery catheter being advanceable through the lumen of the vessel wall penetrating member to said extravascular target site; said vessel wall penetrating member being retractable into the catheter body of the vessel wall penetrating catheter and the vessel wall penetrating catheter being removable from the patient'"'"'s body such that the delivery catheter remains indwelling with the distal end of the delivery catheter located at the extravascular target site. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58)
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59. A system for delivery of a substance to a target site located a spaced distance from a blood vessel within the body of a human or animal patient, said system comprising:
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a vessel wall penetrating catheter that has a flexible catheter body and a vessel wall penetrator advanceable laterally therefrom, said vessel wall penetrating catheter being insertable into the vasculature and positionable in the blood vessel near the target site and said penetrator being thereafter advanceable from the catheter, trough the full thickness of the wall of the blood vessel, and through tissue that is located beyond the blood vessel wall in the direction of the target site; a delivery catheter that is advanceable through the penetrator and to the target site, said delivery catheter being of sufficient length and constructed such that, after the delivery catheter has been advanced through the penetrator and to the target site, the penetrator is retractable into the vessel wall penetrating catheter and the vessel wall penetrating catheter is removable, leaving the delivery catheter in place such that the delivery catheter extends through the patients vasculature into the blood vessel near the target site, outwardly through the wall of the blood vessel and to the target site. - View Dependent Claims (60, 61, 62, 63, 64, 70)
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65. A method for delivery of substances or apparatus to a target site located a spaced distance from a blood vessel within the body of a human or animal patient, said method comprising the steps of:
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(A) inserting a vessel wall penetrating catheter into the vasculature of the patient, said vessel wall penetrating catheter having a flexible catheter body and a penetrator that is advanceable laterally therefrom; (B) positioning the vessel wall penetrating catheter in the blood vessel near the target site; (C) advancing the penetrator laterally from the vessel wall penetrating catheter and though the entire wall of the blood in the direction of the target site; (D) advancing a delivery catheter though the penetrator and to the target site; (E) retracting the penetrator into the vessel wall penetrating catheter; and
,(F) withdrawing and removing the vessel wall penetrating catheter, leaving the delivery catheter indwelling such that it extends though the patient'"'"'s vasculature into the blood vessel near the target site, outwardly though the wall of the blood vessel and to the target site. - View Dependent Claims (66, 67, 68, 69)
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71. A system for delivery of a substance or article to an intramyocardial location in the heart of a mammalian patient, said system comprising:
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a tissue penetrating catheter that is advanceable though the vasculature to a position within a chamber of the heart, said tissue penetrating catheter comprising a flexible catheter body having a distal end and a penetrator outlet port located in the distal end of the catheter body; a tissue penetrator having a hollow bore extending therethrough, the penetrator being advancable from the penetrator outlet port, through the endocardial surface of the heart and into the myocardium; and
,a delivery catheter that is advanceable through the bore of the penetrator and into the myocardial tissue; the substance or article being thereby deliverable through the delivery catheter and into at least one intramyocardial site. - View Dependent Claims (72, 73, 74, 75, 76, 77, 78, 79, 80, 81, 82, 83, 84, 85, 86, 87, 88, 89, 90, 91, 92, 93, 94, 95, 96, 97, 98, 99, 100, 101, 102, 103, 104, 105, 106, 107, 108, 109, 110, 111, 112, 113, 114, 115, 116, 117, 118, 119, 120, 121, 122, 123, 124, 125, 126, 127, 128)
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Specification