Medical device and method of embolizing bronchus or bronchiole

• US 7,357,795 B2
• Filed: 07/19/2002
• Issued: 04/15/2008
• Est. Priority Date: 07/19/2001
• Status: Expired due to Term

• Current Assignee: Olympus Corporation
• Original Assignee: Olympus Corporation
• Inventors: Kaji, Kunihide, Kaji, Hinako
• Primary Examiner(s): Bui; Vy Q.
• Application Number:
  US10/198,779
• Publication Number:
  US 20030018344A1
• Time in Patent Office: 2,097 Days
• Field of Search: 604514-516, 606/200, 606/108, 606/191, 128/898
• US Class Current: 604/514
• CPC Class Codes: A61B 17/12013 for use in minimally invasive surgery, e.g. endoscopic surgery
• CPC Class Codes: A61B 17/12022 Occluding by internal devices, e.g. balloons or releasable wires plugging an opening in the wall of an organ A61B17/0057; occluders for the cervical canal A61F6/146; vas deferens occluders A61F6/20
• CPC Class Codes: A61B 17/12104 in an air passage
• CPC Class Codes: A61B 17/12136 Balloons
• CPC Class Codes: A61B 17/12181 formed by fluidized, gelatinous or cellular remodelable materials, e.g. embolic liquids, foams or extracellular matrices
• CPC Class Codes: A61B 17/12186 liquid materials adapted to be injected
• CPC Class Codes: A61B 2017/1205 Introduction devices
• CPC Class Codes: A61B 2017/22065 Functions of balloons

Abstract

To provide a medical device and a method both of which can suitably embolize a bronchus in a target part by embolizing the bronchus with (at least a part of) a living tissue during surgical treatment of lung emphysema. For example, an injection material is injected into a submucosa by the use of a syringe, and in the injected part, a swelling swollen into the internal cavity of the bronchus is formed to tightly seal the living tissue of the bronchus or a bronchiole, thereby embolizing a target bronchus.

Claims

1. A method of embolizing a bronchus/bronchiole of a subject, comprising:

guiding a puncture portion of an injection device to a part to be embolized in the bronchus/bronchiole of the subject;

puncturing a mucosa of the bronchus/bronchiole in the part to be embolized with the puncture portion of the injection device; and

injecting an injection material into a submucosa of the bronchus/bronchiole to swell an inside wall of the bronchus/bronchiole.

2. The method of embolizing a bronchus/bronchiole according to claim 1, wherein the injection device includes a catheter having, at its leading end, a puncture portion capable of puncturing a mucosa of the bronchus/bronchiole and, at its distal end, a connection portion to which to connect a syringe, the injection material being injected by the syringe.

3. The method of embolizing a bronchus/bronchiole according to claim 1, wherein the injection material contains a fibrin adhesive or collagen.

4. The method of embolizing a bronchus/bronchiole according to claim 1, wherein the injection material is a material in which a particulate substance which is a solid component is suspended in a liquid base material.

5. The method of embolizing a bronchus/bronchiole according to claim 4, wherein the particulate substance is selected from a group consisting of silicone, metal particles, apatite and β

-TCP.

6. The method of embolizing a bronchus/bronchiole according to claim 1, further comprising adding a curing agent to the injected injection material after the injecting of the injection material into the submucosa of the bronchus/bronchiole.

7. The method of embolizing a bronchus/bronchiole according to claim 1, wherein the injection material has a property to expand by absorbing water in a living body.

8. The method of embolizing a bronchus/bronchiole according to claim 2, wherein:

the injection device further includes an endoscope having a channel through which to insert the catheter, and a cap capable of being attached to a leading end of the endoscope, a cap having a sheath which guides a puncture portion of the catheter from a leading opening of the channel to a through-hole opened in the cap,

the method further comprising guiding the puncture portion from the opening of the channel to the through-hole.

9. The method of embolizing a bronchus/bronchiole according to claim 8, wherein:

a balloon is attached to the side opposite to the side in which the through-hole is opened,

the method further comprising expanding the balloon after guiding the puncture portion of the injection device to the part to be embolized.