Death domain containing receptors
First Claim
1. An isolated antibody or fragment thereof which specifically binds to a polypeptide consisting of amino acids 1 to 428 of SEQ ID NO:
- 2.
1 Assignment
0 Petitions
Accused Products
Abstract
The present invention relates to novel Death Domain Containing Receptor (DR3 and DR3-V1) proteins that are members of the tumor necrosis factor (TNF) receptor family. In particular, isolated nucleic acid molecules are provided encoding the human DR3 and DR3-V1 proteins. DR3 and DR3-V1 polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. Also provided are antibodies and fragments thereof that bind to polypeptides of the invention. The invention further relates to screening methods for identifying agonists and antagonists of DR3 and DR3-V1 activity.
16 Citations
24 Claims
- 1. An isolated antibody or fragment thereof which specifically binds to a polypeptide consisting of amino acids 1 to 428 of SEQ ID NO:
- 13. An isolated antibody or fragment thereof which specifically binds to a polypeptide consisting of the amino acid sequence of the full-length polypeptide encoded by the cDNA clone contained in ATCC Deposit No. 97456.
Specification