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System for optimizing alignment of laser beam with selected points on samples in maldi mass spectrometer

  • US 7,359,574 B2
  • Filed: 07/27/2004
  • Issued: 04/15/2008
  • Est. Priority Date: 04/17/2001
  • Status: Expired due to Term
First Claim
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1. A mass spectrometry apparatus comprising:

  • a laser for emitting a laser beam;

    a controller for aiming said laser beam at a sample on a sample plate for mass spectrometry analysis;

    a camera having a field of view comprising the sample on the sample plate, said laser targeting a portion of the sample for laser impingement;

    a processing device configured to;

    receive an image of the sample from said camera;

    analyze the image of the sample to generate control signals for use by said controller to direct the manner in which said laser beam impinges said sample plate and the sample;

    said processing device being operable to;

    identify locations on the sample based on an evaluation of characteristics of the sample; and

    provide position data in said control signals that correspond to said locations; and

    wherein said position data is for said controller to aim said laser at said locations for laser impingement.

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