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Method of treatment of diabetes through induction of immunological tolerance

  • US 7,361,334 B2
  • Filed: 04/13/2004
  • Issued: 04/22/2008
  • Est. Priority Date: 10/26/1995
  • Status: Expired due to Fees
First Claim
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1. A method of treating diabetes in a mammal in need thereof, comprising the steps of:

  • implanting in said mammal a tolerizing dose of insulin-secreting cells encapsulated in a biologically compatible permselective membrane, wherein said implanting step is subcapsular, subcutaneous, intraperitoneal or intraportal;

    thenadministering to said mammal a therapeutic dose of corresponding unencapsulated insulin-secreting cells.

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