Treatment of conditions through modulation of the autonomic nervous system
First Claim
1. A method of treating a subject for at least one of:
- hypoxia, hypercapnia, hypercarbia and acidosis, said method comprising;
modulating at least a portion of said subject'"'"'s autonomic nervous system to increase the parasympathetic activity/sympathetic activity ratio in a manner effective to treat said condition, wherein said parasympathetic activity is increased by increasing activity in at least one parasympathetic nerve fiber; and
decreasing the sensitivity of a chemoreceptor to said at least one of;
hypoxia, hypercapnia, hypercarbia and acidosis.
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Accused Products
Abstract
Methods are provided for treating a subject for a condition caused by an abnormality in the subject'"'"'s autonomic nervous system. In accordance with the subject methods, at least a portion of a subject'"'"'s autonomic nervous system is modulated to increase the parasympathetic activity/sympathetic activity ratio in a manner that is effective to treat the subject for the condition. Certain embodiments include modulating at least a portion of a subject'"'"'s autonomic nervous system by inhibiting and/or increasing activity in at least a portion of the subject'"'"'s autonomic nervous system. The subject methods find use in the treatment of a variety of different conditions, where such conditions include various disease conditions. Also provided are systems and kits for use in practicing the subject methods.
390 Citations
82 Claims
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1. A method of treating a subject for at least one of:
- hypoxia, hypercapnia, hypercarbia and acidosis, said method comprising;
modulating at least a portion of said subject'"'"'s autonomic nervous system to increase the parasympathetic activity/sympathetic activity ratio in a manner effective to treat said condition, wherein said parasympathetic activity is increased by increasing activity in at least one parasympathetic nerve fiber; and decreasing the sensitivity of a chemoreceptor to said at least one of;
hypoxia, hypercapnia, hypercarbia and acidosis. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42)
- hypoxia, hypercapnia, hypercarbia and acidosis, said method comprising;
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43. A method comprising treating a subject for a condition associated with of least one of hypoxia, hypercapnia, hypercarbia and acidosis, said method comprising:
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modulating at least a portion of said subject'"'"'s autonomic nervous system to increase the parasympathetic activity/sympathetic activity ratio in a manner effective to treat said condition, wherein said parasympathetic activity is increased by increasing activity in at least one parasympathetic nerve fiber; and decreasing the sensitivity of a chemoreceptor to said at least one of;
hypoxia, hypercapnia, hypercarbia and acidosis. - View Dependent Claims (44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76, 77, 78, 79, 80, 81, 82)
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Specification