Adaptive timing interval control method for treating congestive heart failure

• US 7,363,077 B1
• Filed: 11/09/2004
• Issued: 04/22/2008
• Est. Priority Date: 11/09/2004
• Status: Active Grant

• Current Assignee: Pacesetter Incorporated (Abbott Laboratories Incorporated)
• Original Assignee: Pacesetter Incorporated (Abbott Laboratories Incorporated)
• Inventors: Min, Xiaoyi, Bornzin, Gene A.
• Primary Examiner(s): Schaetzle; Kennedy J.
• Assistant Examiner(s): Patel; Natasha
• Application Number:
  US10/986,010
• Time in Patent Office: 1,260 Days
• Field of Search: 600/508, 600/510, 600/513, 600/526, 607/2, 607/9, 607/17, 607/18, 607/23, 607/24
• US Class Current: 607/9
• CPC Class Codes: A61N 1/3627 for treating a mechanical deficiency of the heart, e.g. congestive heart failure or cardiomyopathy
• CPC Class Codes: A61N 1/3682 with a variable atrioventricular delay

Abstract

A method of treating a heart with an implantable cardiac stimulation device involves transiently disturbing the steady state hemodynamic parameters by altering a cardiac cycle timing interval sufficient to reduce end diastolic volume for that cycle. The cardiac cycle timing interval is then adaptively controlled for successive cardiac cycles to achieve a second set of hemodynamic parameters.

Claims

1. A method of treating a heart with an implantable cardiac stimulation device, the heart exhibiting initial steady state hemodynamic parameters, the method comprising:

pacing the heart using a first set of pacing parameters comprising at least one cardiac pacing timing interval having an initial steady state value;

disturbing the steady state hemodynamic parameters by altering the cardiac pacing timing interval from the initial steady state value to a temporary value for at least one cardiac cycle sufficient to reduce end diastolic volume for the at least one cardiac cycle; and

adjusting the cardiac pacing timing interval by selecting a desired steady state value within a range defined by the initial steady state value and the temporary value, and changing the cardiac pacing timing interval from the temporary value to the desired steady state value, wherein the desired steady state value is different from the initial steady state value and the temporary value.

2. The method of claim 1 wherein adjusting the cardiac pacing timing interval comprises adaptively controlling the cardiac pacing timing interval for successive cardiac cycles to achieve a second set of hemodynamic parameters.

3. A method of treating the heart according to claim 1 wherein the cardiac pacing timing interval comprises at least one parameter from the group comprising:

heart rate, atrio-ventricular (AV) delay, atrial interconduction (A-A) delay, ventricular interconduction delay (V-V), or ventricular-atrial (V-A) delay.

4. A method of treating the heart according to claim 3 wherein the heart rate cardiac pacing timing interval is defined by a plurality of ventricular events, at least one of the ventricular events comprising a premature ventricular contraction (PVC).

5. A method of treating the heart according to claim 1 wherein disturbing the steady state hemodynamic parameter comprises:

selecting the temporary value; and

incrementally adjusting the cardiac pacing timing interval value from the steady state value to the temporary value in a first series of steps over a predetermined period.

6. A method of treating the heart according to claim 5 wherein the first series of steps comprises a first programmed sequence of between two to ten steps.

7. A method of treating a heart according to claim 1 wherein the desired steady state value is maintained a predetermined number of cardiac cycles.

8. A method of treating a heart according to claim 1 wherein adjusting the cardiac pacing timing interval further comprises:

detecting data indicative of cardiac function.

9. A method of treating a heart according to claim 8 and further comprising:

repeating the disturbing and adjusting if an improvement in cardiac function is determined.

10. A method of treating a heart with an implantable cardiac stimulation device, the heart exhibiting initial steady state hemodynamic parameters, the method comprising:

pacing the heart using a first set of pacing parameters comprising at least one cardiac pacing timing interval having an initial steady state value;

disturbing the steady state hemodynamic parameters by altering the cardiac pacing timing interval from the initial steady state value to a temporary value for at least one cardiac cycle sufficient to reduce end diastolic volume for the at least one cardiac cycle;

adjusting the cardiac pacing timing interval by selecting a desired steady state value within a range defined by the initial steady state value and the temporary value, and changing the cardiac pacing timing interval from the temporary value to the desired steady state value;

adaptively controlling the cardiac pacing timing interval for successive cardiac cycles to achieve a second set of hemodynamic parameters; and

maintaining the second set of hemodynamic parameters as a second set of steady state hemodynamic parameters.

11. A method of treating a heart with an implantable cardiac stimulation device, the heart exhibiting initial steady state hemodynamic parameters, the method comprising:

pacing the heart using a first set of pacing parameters comprising at least one cardiac pacing timing interval having an initial steady state value;

disturbing the steady state hemodynamic parameters by altering the cardiac pacing timing interval from the initial steady state value to a temporary value for at least one cardiac cycle sufficient to reduce end diastolic volume for the at least one cardiac cycle; and

adjusting the cardiac pacing timing interval by selecting a desired steady state value within a range defined by the initial steady state value and the temporary value, and changing the cardiac pacing timing interval from the temporary value to the desired steady state value, wherein the cardiac pacing timing interval is changed from the temporary value to the desired steady state value in a series of steps over a predefined period.

12. An implantable cardiac stimulation device for treating a heart suffering from congestive heart failure, the device comprising:

means for pacing the heart using a first set of pacing parameters comprising at least one cardiac pacing timing interval having an initial steady state value;

means for disturbing steady state hemodynamic parameters of the heart comprising means for altering the cardiac pacing interval from the initial steady state value to a temporary value for at least one cardiac cycle sufficient to reduce end diastolic volume for that cycle; and

means for adjusting the cardiac pacing interval by selecting a desired steady state value within the range defined by the initial steady state value and the temporary value, and changing the cardiac pacing timing interval from the temporary value to the desired steady state value, wherein the desired steady state value is different from the initial steady state value and the temporary value.

13. The implantable cardiac stimulation device of claim 12 wherein the means for altering a cardiac pacing interval comprises means for altering one of heart rate, atrio-ventricular (AV) delay, atrial interconduction (A-A) delay, ventricular interconduction delay (V-V), or ventricular-atrial (V-A) delay.

14. An implantable cardiac stimulation device for treating a heart suffering from congestive heart failure, the device comprising:

means for pacing the heart using a first set of pacing parameters comprising at least one cardiac pacing timing interval having an initial steady state value;

means for disturbing steady state hemodynamic parameters of the heart comprising means for altering the cardiac pacing interval from the initial steady state value to a temporary value for at least one cardiac cycle sufficient to reduce end diastolic volume for that cycle; and

means for adjusting the cardiac pacing interval by selecting a desired steady state value within the range defined by the initial steady state value and the temporary value, and changing the cardiac pacing timing interval from the temporary value to the desired steady state value;

wherein the means for disturbing comprises means for selecting the temporary timing interval value, and means for incrementally adjusting the cardiac pacing interval value from the steady state value to the temporary value.

15. A method of pacing a heart comprising:

pacing the heart using a first set of pacing parameters comprising at least one cardiac pacing timing interval having an initial steady state value;

altering the cardiac pacing timing interval from the initial steady state value to a temporary value for at least one cardiac cycle, wherein the altering is sufficient to reduce end diastolic volume for the at least one cardiac cycle; and

adjusting the cardiac pacing timing interval by selecting a desired steady state value within the range defined by the initial steady state value and the temporary value, and changing the cardiac pacing timing interval from the temporary value to the desired steady state value, wherein the desired steady state value is different from the initial steady state value and the temporary value.

16. An implantable cardiac stimulation system comprising:

at least one lead adapted for implant within a patient and comprising at least one electrode connected to the lead for electrical contact with the patient'"'"'s heart;

an implantable cardiac stimulation device connected to the at least one lead and comprising a controller and a pulse generator, wherein the controller is operative to control the pulse generator to pace the heart using a first set of pacing parameters comprising at least one cardiac pacing timing interval having an initial steady state value, to disturb the steady state hemodynamic parameters by altering the cardiac pacing timing interval from the initial steady state value to a temporary value for at least one cardiac cycle sufficient to reduce end diastolic volume for the at least one cardiac cycle, and to adjust the cardiac pacing timing interval by selecting a desired steady state value within the range defined by the initial steady state value and the temporary value, and changing the cardiac pacing timing interval from the temporary value to the desired steady state value, wherein the desired steady state value is different from the initial steady state value and the temporary value.

17. The implantable cardiac stimulation system of claim 16 wherein the controller is operative to alter one of heart rate, atrio-ventricular (AV) delay, atrial interconduction (A-A) delay, ventricular interconduction delay (V-V), or ventricular-atrial (V-A) delay.

18. The implantable cardiac stimulation system of claim 16 wherein the controller is operative to select the temporary value, and to incrementally adjust the cardiac pacing interval value from the steady state value to the temporary value.