Powder formation by atmospheric spray-freeze drying
First Claim
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1. A method of creating a powder, comprising the steps of:
- spraying a carrier liquid containing a powder forming ingredient to form a flow of liquid droplets;
entraining the flow of liquid droplets within a concurrent flow of coolant for sufficient time to freeze the liquid droplets into frozen particles, the concurrent flow of coolant being sprayed from a ring nozzle; and
drying the frozen particles to form a dry powder.
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Abstract
A method of manufacturing heat-sensitive pharmaceutical powder is disclosed. The original pharmaceutical substances are dissolved in a solution or suspended in a suspension, which is sprayed through an atomizing nozzle and frozen in a cold gas phase or liquid nitrogen atomized directly in the spray-freeze chamber or gas jacket at the same time (for cooling purposes). The particles are freeze-dried at roughly atmospheric pressure in a down-stream fluid flow with exit filter thereby to remove moisture entrapped on or inside the frozen particles. The system has applicability for forming other powders.
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Citations
48 Claims
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1. A method of creating a powder, comprising the steps of:
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spraying a carrier liquid containing a powder forming ingredient to form a flow of liquid droplets; entraining the flow of liquid droplets within a concurrent flow of coolant for sufficient time to freeze the liquid droplets into frozen particles, the concurrent flow of coolant being sprayed from a ring nozzle; and drying the frozen particles to form a dry powder. - View Dependent Claims (13, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27)
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2. A method of creating a powder, comprising the steps of:
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spraying a carrier liquid containing a powder forming ingredient to form a flow of liquid droplets, the flow of liquid droplets being injected into a chamber; entraining the flow of liquid droplets within a concurrent flow of coolant for sufficient time to freeze the liquid droplets into frozen particles, the flow of liquid droplets being entrained by flow of coolant injected through porous walls of the chamber; and drying the frozen particles to form a dry powder. - View Dependent Claims (10, 11, 14, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39)
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3. A method of creating a powder, comprising the steps of:
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spraying a carrier liquid containing a powder forming ingredient to form a flow of liquid droplets; entraining the flow of liquid droplets within a concurrent flow of coolant for sufficient time to freeze the liquid droplets into frozen particles; collecting the frozen particles on a filter; and drying the frozen particles to form a dry powder. - View Dependent Claims (4, 5, 6, 7, 8, 9, 12, 15, 40, 41, 42, 43, 44, 45, 46, 47, 48)
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Specification