Biointerface membrane with macro-and micro-architecture
First Claim
1. A biointerface membrane comprising a biostable membrane configured and arranged to be disposed on an in vivo implantable device, the biostable membrane comprising:
- a macro-architecture defining a plurality of interconnected cavities that are greater than or equal to about 20 microns in a longest dimension; and
a micro-architecture located within at least some of the cavities of the macro-architecture, wherein the micro-architecture has a plurality of interconnected cavities that are less than or equal to about 20 microns in at least one dimension, and wherein the interconnected cavities of the micro-architecture are sized such that a plurality of the interconnected cavities of the micro-architecture fit within one interconnected cavity of the macro-architecture.
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Abstract
Disclosed herein are biointerface membranes including a macro-architecture and a micro-architecture co-continuous with and bonded to and/or located within at least a portion of the macro-architecture. The macro- and micro-architectures work together to manage and manipulate the high-level tissue organization and the low-level cellular organization of the foreign body response in vivo, thereby increasing neovascularization close to a device-tissue interface, interfering with barrier cell layer formation, and providing good tissue anchoring, while reducing the effects of motion artifact, and disrupting the organization and/or contracture of the FBC. The biointerface membranes of the preferred embodiments can be utilized with implantable devices such as devices for the detection of analyte concentrations in a biological sample (for example, from a body), cell transplantation devices, drug delivery devices, electrical signal delivering or measuring devices, and/or combinations thereof.
822 Citations
11 Claims
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1. A biointerface membrane comprising a biostable membrane configured and arranged to be disposed on an in vivo implantable device, the biostable membrane comprising:
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a macro-architecture defining a plurality of interconnected cavities that are greater than or equal to about 20 microns in a longest dimension; and a micro-architecture located within at least some of the cavities of the macro-architecture, wherein the micro-architecture has a plurality of interconnected cavities that are less than or equal to about 20 microns in at least one dimension, and wherein the interconnected cavities of the micro-architecture are sized such that a plurality of the interconnected cavities of the micro-architecture fit within one interconnected cavity of the macro-architecture. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
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Specification