Controlled morphologies in polymer drug for release of drugs from polymer films

• US 7,364,748 B2
• Filed: 04/01/2004
• Issued: 04/29/2008
• Est. Priority Date: 03/30/2001
• Status: Expired due to Fees

• Current Assignee: Advanced Cardiovascular Systems Incorporated
• Original Assignee: Advanced Cardiovascular Systems Incorporated
• Inventors: Claude, Charles David
• Primary Examiner(s): Dodson; Shelley A.
• Assistant Examiner(s): George; Konata M.
• Application Number:
  US10/817,570
• Publication Number:
  US 20040191293A1
• Time in Patent Office: 1,489 Days
• Field of Search: 424/422
• US Class Current: 424/422
• CPC Class Codes: A61K 9/0024 Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue compositions for intravenous administration, normal injectable solutions or dispersions for, e.g. subcutaneous administration A61K9/0019; brain implants A61K9/0085; (coated) prostheses, catheters or stents A61L

Abstract

The present invention includes a drug release system. The drug release system comprises a bulk polymer phase and a polymeric drug-enriched phase within the bulk polymer phase. At least one drug is incorporated into the drug-enriched phase.

Claims

1. An implantable medical device comprising a coating and a therapeutic substance, the coating including a graft polymer having a main chain segment and a side chain segment, wherein the main chain segment has a different degree of solubility than the side chain segment so as to cause phase separation of the segments on the coating on the device and wherein the therapeutic substance has a preferential solubility for one segment over the other segment, wherein the main chain segment includes poly(ethylene-co-vinyl alcohol) and the side chain segment includes poly(ethylene oxide).

2. The implantable medical device of claim 1, wherein the side chain segment is derived from polyethylene oxide having an isocyanate moiety.

7. The implantable medical device of claim 1 which is a stent.

3. An implantable medical device comprising a coating, the coating including a poly(ethylene-co-vinyl alcohol) conjugated to a polyethylene oxide.

4. The implantable device of claim 3, additionally comprising a drug.

5. The implantable device of claim 3, additionally comprising a drug having preferential solubility for the polyethylene oxide.

8. The implantable medical device of claim 3 which is a stent.

6. An implantable medical device comprising a coating, the coating including a product of reaction of poly(ethylene-co-vinyl alcohol) and a polyethylene oxide having an isocyanate functionality.

9. The implantable medical device of claim 6 which is a stent.