Tendon-inducing methods

• US 7,365,052 B2
• Filed: 06/17/2005
• Issued: 04/29/2008
• Est. Priority Date: 12/07/1993
• Status: Expired due to Fees

• Current Assignee: President and Fellows of Harvard College (Harvard Corporation), Genetics Institute LLC (Pfizer Inc.)
• Original Assignee: President and Fellows of Harvard College (Harvard Corporation), Genetics Institute LLC (Pfizer Inc.)
• Inventors: Wozney, John M., Rosen, Vicki A., Celeste, Anthony J., Melton, Douglas A., Wolfman, Neil M., Thomsen, Gerald H.
• Primary Examiner(s): KEMMERER, ELIZABETH
• Application Number:
  US11/154,826
• Publication Number:
  US 20070004005A1
• Time in Patent Office: 1,047 Days
• Field of Search: None
• US Class Current: 514/8.8
• CPC Class Codes: A61K 38/1875 Bone morphogenic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
• CPC Class Codes: A61L 27/227 Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
• CPC Class Codes: A61L 27/386 Ligaments, tendons
• CPC Class Codes: A61L 27/54 Biologically active materials, e.g. therapeutic substances A61L27/227 takes precedence
• CPC Class Codes: A61P 1/02 Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
• CPC Class Codes: A61P 17/02 for treating wounds, ulcers, burns, scars, keloids, or the like
• CPC Class Codes: A61P 19/02 for joint disorders, e.g. arthritis, arthrosis
• CPC Class Codes: A61P 19/04 for non-specific disorders of the connective tissue
• CPC Class Codes: A61P 19/08 for bone diseases, e.g. rachitism, Paget's disease
• CPC Class Codes: A61P 43/00 Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
• CPC Class Codes: A61P 5/00 Drugs for disorders of the endocrine system
• CPC Class Codes: C07K 14/51 Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
• CPC Class Codes: C07K 2319/02 containing a signal sequence

Abstract

Compositions of proteins with tendon/ligament-like tissue inducing activity are disclosed. The compositions are useful in the treatment of tendinitis and tendon or ligament defects and in related tissue repair.

Claims

1. A method for regenerating a functional attachment between tendon and/or ligament tissue and bone comprising administering an effective amount of a BMP-13 protein, or an MP-52 protein, or mixtures or heterodimers thereof, to a patient in need of same.

2. The method of claim 1, wherein the protein administered is BMP-13.

3. The method of claim 1, wherein the protein administered is MP-52.

4. A method for treating a tendon and/or ligament defect comprising administering an effective amount of a BMP-13 protein, or an MP-52 protein, or mixtures or heterodimers thereof, to a patient in need of same.

5. The method of claim 4, wherein the protein administered is BMP-13.

6. The method of claim 4, wherein the protein administered is MP-52.