Sensor for detection of liquid ingredients, particularly for biological materials and the detection device contained in the sensor

• US 7,367,221 B2
• Filed: 04/28/2005
• Issued: 05/06/2008
• Est. Priority Date: 04/28/2004
• Status: Active Grant

• Current Assignee: Fraunhofer Gesellschaft Zur Foerderung Der Angewandten Forsching E.V.
• Original Assignee: Fraunhofer Gesellschaft Zur Foerderung Der Angewandten Forsching E.V.
• Inventors: Hintsche, Rainer
• Primary Examiner(s): LARKIN, DANIEL SEAN
• Application Number:
  US11/119,298
• Publication Number:
  US 20050268701A1
• Time in Patent Office: 1,104 Days
• Field of Search: 73/530.1, 73/614.1, 422/58, 422/82.01, 422/82.02, 422/98
• US Class Current: 73/53.01
• CPC Class Codes: G01N 27/403 Cells and electrode assemblies

Abstract

This invention relates to a sensor for the detection of liquid ingredients with a carrier element (10), a sensor element (1) on the carrier element (10) and a sensor array, which is disposed on the surface of the sensor element and contains one or more electrodes (2), which are in electrical contact (4) with the corresponding deflection surfaces (3), which are also on the surface of the sensor element (1), but otherwise not electrically connected to the carrier element (10). The sensor forms a detection unit together with a detachable cover, which has at least one fluid channel (7) for the feed line, as well as at least one contacting element (5) and which forms together with the sensor at least one hollow space (8) above the surface of the sensor element (1), where there is the surface or part of a surface of at least one electrode (2), but no deflection surface (3), while each contacting element is in such a manner disposed, that it contacts a corresponding deflection surface when the sensor connects with the cover. In specific embodiments, the sensor itself comprises in addition a covering element (6) firmly attached to the sensor, which constitutes at least one filling opening (12) and at least one hollow space (8) above a sensor element'"'"'s surface (1), where there is the surface or part of a surface of at least one electrode (2), but no deflection surface (3). When connecting this sensor to a contacting element (5), it forms a detection unit, whereby each contacting element is in such a manner disposed, that it can connect to a corresponding deflection surface (3) of the sensor.

Claims

1. Sensor for the detection of liquid ingredients, comprising:

a carrier element,

a sensor element on the carrier element, and

a sensor array, which is disposed on the sensor element'"'"'s surface and contains one or several electrodes, which are in electrical contact with associated deflection surfaces, which are also located on the surface of the sensor element, but otherwise not in electrical connection with the carrier element.

2. Sensor according to claim 1, wherein the sensor element is made of silicon or glass or plastic.

3. Sensor according to claim 1 wherein electrical contacts are realized between the electrodes and the deflection surfaces in the same horizontal layer as those on the surface of the element.

4. Sensor according to claim 1 wherein the electrodes and the deflection surfaces are placed in the surface of the sensor element or separated as a thin metallic layer on top of it.

5. Sensor according to claim 4, wherein electrical contacts between the electrodes and the deflection surfaces are also located in the sensor element'"'"'s surface, or are deposited as a thin metallic layer on top of it, so that the electrodes, the deflection surfaces and the electrical contacts are manufactured together or consecutive and integral.

6. Sensor according to claim 1 wherein electrical contacts between the electrodes and the deflection surfaces are covered by an insulating material from the surface of the sensor element.

7. Sensor according to claim 6, wherein the insulating material is present as a thin layer on the electrical contacts.

8. Sensor according to claim 6, wherein the insulating material from the surface of the sensor element is an inorganic oxide, a nitride, an oxynitride, or an organic or inorganic-organic plastic.

9. Sensor according to claim 8, wherein the inorganic oxide is SiO₂.

10. Sensor according to claim 8, wherein the oxynitride is silicon-oxynitride.

11. Sensor according to claim 1, wherein electrical contacts are embedded as integrated circuits in the sensor element.

12. Sensor according to claim 1, further comprising:

a covering element firmly attached to the sensor, which constitutes at least one filling opening and at least one hollow space above the sensor element'"'"'s surface, wherein there is a surface or part of a surface of at least one electrode exposed, but no deflection surface.

13. Sensor according to claim 12, wherein the hollow space is sealed from other parts of the sensor through sealing elements.

14. Sensor according to claim 12, wherein the covering element is fastened to the carrier element and/or to the sensor element, particularly with adhesive joints, and includes a recess in the area of the deflection surfaces, so that the deflection surfaces are exposed.

15. Sensor according to claim 12, wherein each filling opening is connected to the hollow space through a fluid line, while one, or each fluid line is optionally equipped with one or more supply niches for the absorption of supply reagents.

16. Sensor according to claim 12, wherein the covering element has at least one feeding channel and at least one draining channel.

17. Detection unit for the detection of liquid ingredients, comprising a sensor according to claim 1, and further comprising:

a detachable cover, which has at least one fluid channel for feeding purposes, as well as at least one contacting element and when connecting the sensor with the cover, the cover builds with the sensor at least one hollow space above the surface of the sensor element, where there is the surface or part of a surface of at least one electrode exposed, but no deflection surface, while each contacting element is in such a manner disposed, that it contacts a corresponding deflection surface when the sensor connects with the cover.

18. Detection unit according to claim 17, wherein the contacting elements are pin contacts or spring contacts or that the contacting elements are built as fixed contacts.

19. Detection unit according to claim 17, wherein the cover has at least one feeding channel and at least one discharge channel.

20. Detection unit according to claim 17 wherein either the sensor and/or the cover contain at least one sealing element, which ensures, optionally together with other sealing elements a liquid-tight sealing of the hollow space.

21. Detection unit according to claim 20, wherein the sealing element is an O-ring or a sealing foil.

22. Detection unit according to claim 17, wherein the cover contains a carrier, through which one or more fluid channels pass.

23. Detection unit according to claim 22 wherein the cover'"'"'s carrier includes a recess, which is part of the hollow space.

24. Detection unit according to claim 17 wherein the cover contains a retractable device, a lever device or a clicking device, which connects the cover to the sensor and also separates the cover from the sensor.

25. Detection unit according to claim 24, wherein the retractable device, the lever device or the clicking device is connected to the carrier.

26. Detection unit according to claim 17 wherein the cover contains at least one covering element, through which pass one or more fluid channels and which includes a recess, while the contacting elements are disposed farther from the covering element.

27. Detection unit according to claim 17, wherein one or more fluid channels are closed with a septum, which can be punctured with a hollow needle.

28. Detection unit for the detection of liquid ingredients, comprising a sensor according to claim 12, and further comprising

at least one contacting element, whereby each contacting element is disposed in such a manner that it can connect to a corresponding deflection surface of the sensor.

29. Detection unit according to claim 28, wherein the contacting elements are fastened to a carrier, which includes at least one flow-through channel, to such an extent that, when connecting the sensor with the carrier each contacting element can come in connection with a corresponding deflection surface and each flow-through channel communicates with a fluid channel.

30. Detection unit according to claim 29, wherein each flow-through channel includes at least one sealing element at a bottom end, for a detachable sealing connection of the flow-through channel and fluid channel.

31. Detection unit according to claim 29, wherein the cover contains a retractable device, a lever device or a clicking device, which connects the cover to the sensor and also separates the cover from the sensor.

32. Detection unit according to claim 29 wherein one or more fluid channels are closed with a septum, which can be punctured with a hollow needle.

33. Detection unit according to claim 28, wherein the contacting elements are pin contacts or spring contacts or that the contacting elements are built as fixed contacts.