Biochemical analysis unit and method for producing thereof

• US 7,368,026 B2
• Filed: 01/31/2003
• Issued: 05/06/2008
• Est. Priority Date: 01/31/2002
• Status: Expired due to Fees

• Current Assignee: Fujifilm Corporation (Fujifilm Holdings Corporation)
• Original Assignee: Fujifilm Corporation (Fujifilm Holdings Corporation)
• Inventors: Nakajima, Kenji, Kato, Akifumi
• Primary Examiner(s): Sells; James
• Application Number:
  US10/355,257
• Publication Number:
  US 20030153070A1
• Time in Patent Office: 1,922 Days
• Field of Search: 156/250, 156/256, 156/261, 156/269, 156/555, 156/580, 156/582, 156/583.1, 156/196, 156/199, 156/293
• US Class Current: 156/199
• CPC Class Codes: B01J 19/0046 Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays synthesis methods per se C40B50/00
• CPC Class Codes: B01J 2219/00378 Piezoelectric or ink jet dispensers
• CPC Class Codes: B01J 2219/00387 Applications using probes
• CPC Class Codes: B01J 2219/00527 Sheets
• CPC Class Codes: B01J 2219/00574 radioactive
• CPC Class Codes: B01J 2219/00576 fluorophore
• CPC Class Codes: B01J 2219/00578 electrophoric
• CPC Class Codes: B01J 2219/00585 Parallel processes
• CPC Class Codes: B01J 2219/00596 Solid-phase processes
• CPC Class Codes: B01J 2219/00644 the porous medium being present in discrete locations, e.g. gel pads
• CPC Class Codes: B01J 2219/00677 Ex-situ synthesis followed by deposition on the substrate
• CPC Class Codes: B01J 2219/00722 Nucleotides
• CPC Class Codes: B01L 2200/12 Specific details about manufacturing devices
• CPC Class Codes: B01L 2300/069 Absorbents; Gels to retain a fluid
• CPC Class Codes: B01L 2300/0829 Multi-well plates; Microtitration plates
• CPC Class Codes: B01L 2300/168 Specific optical properties, e.g. reflective coatings
• CPC Class Codes: B01L 3/5085 for multiple samples, e.g. microtitration plates
• CPC Class Codes: G01N 33/54366 Apparatus specially adapted for solid-phase testing
• CPC Class Codes: G01N 33/54393 Improving reaction conditions or stability, e.g. by coating or irradiation of surface, by reduction of non-specific binding, by promotion of specific binding
• CPC Class Codes: Y10T 156/1002 with permanent bending or reshaping or surface deformation of self sustaining lamina
• CPC Class Codes: Y10T 156/1007 : Running or continuous length work
• CPC Class Codes: Y10T 156/107 : Punching and bonding pressure application by punch

Abstract

In producing a biochemical analysis unit (1), an adhesive agent (25) is applied to a base. After calcinations, the adhesive agent (25) forms an adhesive layer (25a, 25b) on a wall of each holes (3) formed in the base (2). Thereafter, an excess adhesive agent (25c) remaining on the surface of the base (2) is removed. Then, a sheet of an absorptive material (4) is set to overlap the base (2). A press roller pair (27, 28) presses them to charge the absorptive material (4) in the holes (3). Thus the absorptive material (4) is fixed in the hole (3) of the base (2) through the adhesive layer (25a, 25b).

Claims

1. A method for producing a biochemical analysis unit (1), comprising steps of:

forming an adhesive layer (25a, 25b) on a wall of each hole formed in a base (2), said base (2) being sheet-like shaped;

overlapping an absorptive material (4) with a surface of said base (2);

pressing said absorptive material (4) to said base (2) with press member (27, 28) so as to charge part of said absorptive material (4) in said holes (3) and to adhere said absorptive material (4) to said wall of said hole (3) through said adhesive layer (25a, 25b).

2. A method as claimed in claim 1, wherein said press members (27, 28) are a press roller pair (27, 28), a first roller (27) of said press roller pair (27, 28) that contacts to said base is heated, and a temperature of said first roller (27) being higher than a glass transition temperature of said adhesive agent (25).

3. A method as claimed in claim 2, wherein said temperature of said first roller (27) is lower that all of said adhesive layer, said absorptive material and said base.

4. A method as claimed in claim 2, wherein said temperature of said first roller (27) is adjusted.

5. A method as claimed in claim 2, wherein said glass transition temperature is −

20°

C. to 50°

C.

6. A method as claimed in claim 2, wherein said base (2) is formed of at least one of metal materials, ceramic materials and plastic materials.

7. A method as claimed in claim 2, a step for forming said adhesive layer (25a, 25b) comprising steps of:

applying an adhesive agent (25) on said base (2); and

carrying out calcinations of said adhesive agent (25) on said base (2).

8. A method as claimed in claim 7, further comprising a step of carrying out processing a surface of said base (2) in a corona discharging method, a corona discharging method, or a cathode oxidization method before the step of forming said adhesive layer (25a, 25b), in order to form said adhesive layer (25a, 25b) certainly.

9. A method as claimed in claim 7, wherein said adhesive agent (25) is styrene butadiene rubber or acrylonitrile butadiene rubber.

10. A method as claimed in claim 9, further comprising a step of blowing away, sucking away, or wiping out with a cloth an excess adhesive agent (25c) remaining on said surface of said base (2) before carrying out the calcinations.

11. A method as claimed in claim 10, further comprising a step of making laser ablation, punching, or heating after carrying out the calcinations, said laser ablation and said punching removing an excess adhesive agent in said holes (3), and said heating melting said excess adhesive agent in said holes (3).